Decoupled Lead Time in finite capacity flowshop: a feedback loop approach

Author(s):  
Guillaume Dessevre ◽  
Guillaume Martin ◽  
Pierre Baptiste ◽  
Jacques Lamothe ◽  
Robert Pellerin ◽  
...  
2013 ◽  
Vol 66 (4) ◽  
pp. 808-817 ◽  
Author(s):  
Saeed Yaghoubi ◽  
Siamak Noori ◽  
Amir Azaron

Author(s):  
Yu-Feng Wei ◽  
Anna C. Thornton

In this paper we propose a quantitative method for optimizing the design tasks at the product, process, and system level based on predicted system performance. We develop a set of models for a production system that comprises two plants: manufacturing and assembly, with a finished-good inventory in between, and seek to optimize the part design, tolerancing, production and inventory control concurrently. Such an approach provides an efficient manufacturing feedback loop for the design tasks and can significantly shorten the product development lead-time. A case study of an aircraft tube production system is used to illustrate this methodology.


2007 ◽  
Vol 2007 ◽  
pp. 1-23 ◽  
Author(s):  
A. Krishnamoorthy ◽  
K. P. Jose

We analyze and compare three (s,S) inventory systems with positive service time and retrial of customers. In all of these systems, arrivals of customers form a Poisson process and service times are exponentially distributed. When the inventory level depletes to s due to services, an order of replenishment is placed. The lead-time follows an exponential distribution. In model I, an arriving customer, finding the inventory dry or server busy, proceeds to an orbit with probability γ and is lost forever with probability (1−γ). A retrial customer in the orbit, finding the inventory dry or server busy, returns to the orbit with probability δ and is lost forever with probability (1−δ). In addition to the description in model I, we provide a buffer of varying (finite) capacity equal to the current inventory level for model II and another having capacity equal to the maximum inventory level S for model III. In models II and III, an arriving customer, finding the buffer full, proceeds to an orbit with probability γ and is lost forever with probability (1−γ). A retrial customer in the orbit, finding the buffer full, returns to the orbit with probability δ and is lost forever with probability (1−δ). In all these models, the interretrial times are exponentially distributed with linear rate. Using matrix-analytic method, we study these inventory models. Some measures of the system performance in the steady state are derived. A suitable cost function is defined for all three cases and analyzed using graphical illustrations.


2015 ◽  
Vol 58 ◽  
pp. 83-100 ◽  
Author(s):  
Selena Gimenez-Ibanez ◽  
Marta Boter ◽  
Roberto Solano

Jasmonates (JAs) are essential signalling molecules that co-ordinate the plant response to biotic and abiotic challenges, as well as co-ordinating several developmental processes. Huge progress has been made over the last decade in understanding the components and mechanisms that govern JA perception and signalling. The bioactive form of the hormone, (+)-7-iso-jasmonyl-l-isoleucine (JA-Ile), is perceived by the COI1–JAZ co-receptor complex. JASMONATE ZIM DOMAIN (JAZ) proteins also act as direct repressors of transcriptional activators such as MYC2. In the emerging picture of JA-Ile perception and signalling, COI1 operates as an E3 ubiquitin ligase that upon binding of JA-Ile targets JAZ repressors for degradation by the 26S proteasome, thereby derepressing transcription factors such as MYC2, which in turn activate JA-Ile-dependent transcriptional reprogramming. It is noteworthy that MYCs and different spliced variants of the JAZ proteins are involved in a negative regulatory feedback loop, which suggests a model that rapidly turns the transcriptional JA-Ile responses on and off and thereby avoids a detrimental overactivation of the pathway. This chapter highlights the most recent advances in our understanding of JA-Ile signalling, focusing on the latest repertoire of new targets of JAZ proteins to control different sets of JA-Ile-mediated responses, novel mechanisms of negative regulation of JA-Ile signalling, and hormonal cross-talk at the molecular level that ultimately determines plant adaptability and survival.


2014 ◽  
Vol 1 ◽  
pp. 636-639
Author(s):  
Fernanda S. Matias ◽  
Pedro V. Carelli ◽  
Claudio R. Mirasso ◽  
Mauro Copelli

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