fastTIGER: A rapid method for estimating evolutionary rates of sites from large datasets

Author(s):  
Thu Kim Le ◽  
Vinh Sy Le
Author(s):  
M. D. Vaudin ◽  
J. P. Cline

The study of preferred crystallographic orientation (texture) in ceramics is assuming greater importance as their anisotropic crystal properties are being used to advantage in an increasing number of applications. The quantification of texture by a reliable and rapid method is required. Analysis of backscattered electron Kikuchi patterns (BEKPs) can be used to provide the crystallographic orientation of as many grains as time and resources allow. The technique is relatively slow, particularly for noncubic materials, but the data are more accurate than any comparable technique when a sufficient number of grains are analyzed. Thus, BEKP is well-suited as a verification method for data obtained in faster ways, such as x-ray or neutron diffraction. We have compared texture data obtained using BEKP, x-ray diffraction and neutron diffraction. Alumina specimens displaying differing levels of axisymmetric (0001) texture normal to the specimen surface were investigated.BEKP patterns were obtained from about a hundred grains selected at random in each specimen.


2017 ◽  
Vol 25 (2) ◽  
pp. 927-960
Author(s):  
Jarod Jacobs

In this article, I discuss three statistical tools that have proven pivotal in linguistic research, particularly those studies that seek to evaluate large datasets. These tools are the Gaussian Curve, significance tests, and hierarchical clustering. I present a brief description of these tools and their general uses. Then, I apply them to an analysis of the variations between the “biblical” DSS and our other witnesses, focusing upon variations involving particles. Finally, I engage the recent debate surrounding the diachronic study of Biblical Hebrew. This article serves a dual function. First, it presents statistical tools that are useful for many linguistic studies. Second, it develops an analysis of the he-locale, as it is used in the “biblical” Dead Sea Scrolls, Masoretic Text, and Samaritan Pentateuch. Through that analysis, this article highlights the value of inferential statistical tools as we attempt to better understand the Hebrew of our ancient witnesses.


2018 ◽  
Author(s):  
Andrew Dalke ◽  
Jerome Hert ◽  
Christian Kramer

We present mmpdb, an open source Matched Molecular Pair (MMP) platform to create, compile, store, retrieve, and use MMP rules. mmpdb is suitable for the large datasets typically found in pharmaceutical and agrochemical companies and provides new algorithms for fragment canonicalization and stereochemistry handling. The platform is written in Python and based on the RDKit toolkit. mmpdb is freely available.


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