The work is devoted to mathematical simulation of laboratory experiments on the single-phase fluid displacement in synthetic porous samples. The basis of the mathematical model used is the system of poroelasticity equations in terms of the Biot's model, which implies that the processes of fluid filtration and the dynamics of changes in the stress-strain state of a continuous medium are considered together in the framework of a single coupled statement. For simulation, the software package developed at the Keldysh Institute of Applied Mathematics, Russian Academy of Sciences, was used. The laboratory experiments considered in this work were performed at the Institute of Geosphere Dynamics, Russian Academy of Sciences. The mathematical model used is briefly presented; the main computational algorithms and the features of their software implementation are described. A detailed description of the laboratory set-up, laboratory experiments themselves and their results are given. A significant part of the work is devoted to the problem statement description in terms of mathematical simulation. The results of calculations are presented; the calculated and experimentally observed dependencies are compared. The possible causes of the observed deviations are analyzed.