Automatic Treatment Regimen Design

2021 ◽  
Vol 33 (11) ◽  
pp. 3494-3506
Author(s):  
Leilei Sun ◽  
Chuanren Liu ◽  
Guoqing Chen ◽  
Chonghui Guo ◽  
Hui Xiong ◽  
...  
2019 ◽  
pp. 12-17
Author(s):  
G.M. Bondarenko ◽  
◽  
Yu.V. Shcherbakova ◽  
V.B. Chirva ◽  
S.V. Teslenko ◽  
...  

2020 ◽  
Vol 15 ◽  
Author(s):  
Manasi M. Chogale ◽  
Sujay S. Gaikwad ◽  
Savita P. Kulkarni ◽  
Vandana B. Patravale

Background: Tuberculosis (TB) continues to be among the leading causes for high mortality among developing countries. Though a seemingly effective treatment regimen against TB is in place, there has been no significant improvement in the therapeutic rates. This is primarily owing to the high drug doses, their associated sideeffects, and prolonged treatment regimen. Discontinuation of therapy due to the severe side effects of the drugs results in the progression of the infection to the more severe drug-resistant TB. Objectives: Reformulation of the current existing anti TB drugs into more efficient dosage forms could be an ideal way out. Nanoformulations have been known to mitigate the side effects of toxic, high-dose drugs. Hence, the current research work involves the formulation of Isoniazid (INH; a first-line anti TB molecule) loaded chitosan nanoparticles for pulmonary administration. Methods: INH loaded chitosan nanoparticles were prepared by ionic gelation method using an anionic crosslinker. Drugexcipient compatibility was evaluated using DSC and FT-IR. The formulation was optimized on the principles of Qualityby-Design using a full factorial design. Results: The obtained nanoparticles were spherical in shape having an average size of 620±10.97 nm and zeta potential +16.87±0.79 mV. Solid state characterization revealed partial encapsulation and amorphization of INH into the nanoparticulate system. In vitro release study confirmed an extended release of INH from the system. In vitro cell line based safety and efficacy studies revealed satisfactory results. Conclusion: The developed nanosystem is thus an efficient approach for antitubercular therapy.


2001 ◽  
Vol 19 (2) ◽  
pp. 127-136 ◽  
Author(s):  
John C. Grecula ◽  
David E. Schuller ◽  
Roy Smith ◽  
Chris A. Rhoades ◽  
Subir Nag ◽  
...  

2021 ◽  
pp. 074880682198989
Author(s):  
Alix Ferdinand ◽  
Suzan Obagi

The interest in cosmetic procedures for patients with skin of color is on an upward trend. Globally, dyschromia and hyperpigmentation remain the most common disorders for which patients seek treatment. The goals of a perioperative skin conditioning program include allowing a broad range of patients to be treated regardless of skin phototypes, maximizing results, and reducing risk of complications such as post-inflammatory hyperpigmentation and managing post-inflammatory hyperpigmentation if it occurs. The purpose of this article is to highlight common pigmentation concerns among patients with skin of color, the topical agents used to combat these concerns, and a practical approach to creating an effective yet straightforward topical skin care regimen that can be used across a wide range of patient skin phototypes. Before and after photos of patients with a variety of pigmentation concerns are presented along with a description of the treatment regimen used to improve their conditions and to get their skin to a safer state prior to performing any office-based procedures. By understanding the main concerns of patients with skin of color, one can use a simple and effective skincare regimen to allow these patients to be more safely treated. An effective skincare regimen both prepares the skin prior to procedures and postoperatively to help minimize dyschromias in the postoperative phase.


2020 ◽  
Vol 79 (Suppl 1) ◽  
pp. 915.1-915
Author(s):  
R. Grekhoff

Background:Objectives:Our aim was to study the effect of biofeedback (BFB) training on the locus of control in patients suffering from rheumatoid arthritis (RA), and to justify the use of this method in the complex treatment of the disease.Methods:40 RA patients hospitalized in the rheumatology department were examined. The average age of patients was 48. 6 years ± 7.73 years (from 30 to 70 years), women accounted for the majority = 26 (86%), the average duration of the disease was 12 years ± 3.44 years. We use J. Rotter’s Locus of Control Scale in E.F.Bazhin adaptation. RA patients were divided into two groups: the main (20 patients) and control (20 patients). Patients of the main group received complex therapy with 12 sessions of BFB training, mainly based on the parameters of the brain’s electrical activity — EEG relaxation using the Reakor™ psychophysiological rehabilitation complex manufactured by Medicom MTD (Taganrog).Results:We revealed externality in RA patients in the general field (3.03 ± 0.3), as well as in the field of relation to the disease (3.86 ± 0.23) and in the field of production relations (3.43 ± 0, 25). After BFB trainings, an increase in internality was observed on the scales of the general sphere (p <0.05) and attitude to the disease (p <0.01) in patients of the main group. In the group of patients receiving conventional treatment, the dynamics of the results was unreliable.Conclusion:It should be noted that the locus of control (or subjective control) is a quality that characterizes a person’s tendency to attribute responsibility for the results of his activity to external forces, or to his own abilities and efforts. Externality is manifested when people prefer to shift responsibility for important events of their life to external circumstances, and external forces (bosses, colleagues, etc.). In the field of attitude to the disease, externality is manifested when patient behaves passively, and believes that he cannot influence the course of the disease in any way, shifting all responsibility for the treatment results to medical staff, which can lead to non-compliance with the treatment regimen and an increase in the level of anxiety and depression, decreased self-esteem. The onset of the disease and its associated social consequences (disability, loss of social roles, etc.) can cause a negative mental state of learned helplessness. Learned helplessness is defined as a condition that occurs as a result of uncontrolled, mainly negative events, which manifests itself in violations of emotional, motivational and cognitive processes. In other words, RA patient suffering from this condition expects treatment failures and reduces control over compliance with the treatment regimen. BFB therapy can be used in order to correct and prevent the state of learned helplessness by increasing the level of internality.It is assumed that increasing internality in the BFB process is associated with teaching the patient the skills of self-regulation of physiological processes. The mechanisms of BFB therapeutic effect are not only changes in physiological parameters (improvement of cerebral and peripheral blood flow, muscle relaxation, and improvement of sleep) but also in a shift in the locus of control from external to internal, which can increase compliance, reduce neurotic complaints, mobilize volitional potential and improve patient self-esteem.As a result of BFB course, an increase in the internality was noted in patients on the scales of the general sphere and the sphere of attitude to the disease. It is advisable to use the BFB to increase the compliance and effectiveness of complex treatment of RA patients.Disclosure of Interests:None declared


2021 ◽  
pp. 019459982110069
Author(s):  
Lauren E. Miller ◽  
Neil Bhattacharyya

Chronic rhinosinusitis (CRS) management frequently comprises conservative treatment, including a combination of topical and oral corticosteroids (OCSs). However, in the midst of the coronavirus disease 2019 (COVID-19) pandemic, providers may have been reluctant to prescribe OCSs out of possible concern for an increased risk of contracting COVID-19 or developing more severe COVID-19 symptoms. This study thus sought to explore the association between the use of OCSs and the development of COVID-19 in patients with CRS. We found no statistically significant difference in the rates of patients with a positive diagnosis of COVID-19 who underwent an OCS treatment regimen compared to those who did not, both within 28 days ( P = .389) and 14 days ( P = .676) prior to the COVID-19 test. Given OCSs are often a major component of medical management of CRS, this study proves helpful in counseling patients on risks of steroid use in CRS treatment during the COVID-19 pandemic.


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