scholarly journals The association between soya consumption and serum thyroid-stimulating hormone concentrations in the Adventist Health Study-2

2015 ◽  
Vol 19 (8) ◽  
pp. 1464-1470 ◽  
Author(s):  
Serena Tonstad ◽  
Karen Jaceldo-Siegl ◽  
Mark Messina ◽  
Ella Haddad ◽  
Gary E Fraser
Keyword(s):  
Urinary Iodine ◽  
Thyroid Stimulating Hormone ◽  
Soya Protein ◽  
High Serum ◽  
Health Study ◽  
Animal Products ◽  
White Ethnicity ◽  
High Consumption ◽  
Stimulating Hormone ◽  
Adventist Health Study

AbstractObjectiveConsumers may choose soya foods as healthful alternatives to animal products, but concern has arisen that eating large amounts of soya may adversely affect thyroid function. The present study aimed to examine the association between soya food consumption and serum thyroid-stimulating hormone (TSH) concentrations in North American churchgoers belonging to the Seventh-day Adventist denomination that encourages vegetarianism.DesignParticipants completed six repeated 24 h dietary recalls within a 6-month period. Soya protein and soya isoflavone intakes were estimated, and their relationships to TSH concentrations measured at the end of 6 months were calculated using logistic regression analyses.SettingCalibration sub-study of the Adventist Health Study-2.SubjectsWomen (n 548) and men (n 295) who were not taking thyroid medications.ResultsIn men, age and urinary iodine concentrations were associated with high serum TSH concentrations (>5 mIU/l), while among women White ethnicity was associated with high TSH. In multivariate models adjusted for age, ethnicity and urinary iodine, soya isoflavone and protein intakes were not associated with high TSH in men. In women higher soya isoflavone consumption was associated with higher TSH, with an adjusted odds ratio (highest v. lowest quintile) of 4·17 (95 % CI 1·73, 10·06). Likewise, women with high consumption of soya protein (midpoint of highest quintile, 11 g/d) v. low consumption (midpoint of lowest quintile, 0 g/d) carried increased odds of high TSH (OR=2·69; 95 % CI 1·34, 5·30).ConclusionsIn women high consumption of soya was associated with elevated TSH concentrations. No associations between soya intake and TSH were found in men.

Original Paper: Assays for thyroid-stimulating hormone using dried blood spotted filter paper specimens to screen for hypothyroidism in older children and adults

2003 ◽  
Vol 10 (1) ◽  
pp. 5-10 ◽  
Author(s):  
L F Hofman ◽  
T P Foley ◽  
J J Henry ◽  
E W Naylor
Keyword(s):  
Nursing Homes ◽  
Filter Paper ◽  
Cost Effective ◽  
Dried Blood Spots ◽  
Thyroid Stimulating Hormone ◽  
High Serum ◽  
Thyroid Peroxidase ◽  
Older Children ◽  
Finger Stick ◽  
Stimulating Hormone

Objective: Symptoms of hypothyroidism in adults can be mistaken for medical and psychiatric diseases, as well as for general signs of ageing such as weakness, lethargy and fatigue. The incidence of hypothyroidism is many-fold higher in adults than in newborn children. The latter have been routinely screened for the condition using filter paper dried blood spots (DBS) for nearly three decades but this cost-effective screening technique has only recently been applied to adults. This study was undertaken to show that DBS testing in adults and older children is an accurate way to screen for hypothyroidism. Methods: Serum and DBS specimens were collected from adults and children. Assays were run on both specimens and the results correlated. In addition 972 specimens were collected from adults at community centres and nursing homes. Follow-up studies were performed on patients with positive results. Results: The correlation coefficient for 118 matched serum and DBS specimens was 0.99. Thyroid-stimulating hormone (TSH) values were elevated in 50 of the 972 adults from nursing homes and community centres. Thirteen of these individuals were on thyroid medication and 28 had either high serum TSH or high thyroglobulin (TgAb) or thyroid peroxidase (TPOAb) antibody levels. Conclusions: Individuals can be screened for hypothyroidism by collecting finger stick DBS specimens at community centres, nursing homes and other locations which can be mailed by regular postal service to a central laboratory for accurate and inexpensive testing.

scholarly journals Thyroid stimulating hormone isn’t a sensitive indicator of iodine nutritional status in schoolchildren

2016 ◽  
Vol 14 (3) ◽  
pp. 350
Author(s):  
Renata De Oliveira Campos ◽  
Joaquim Custódio Silva Júnior ◽  
Elton Estrela Ramos
Keyword(s):  
Public Schools ◽  
Nutritional Status ◽  
Filter Paper ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Iodine Nutrition ◽  
Cross Sectional ◽  
Stimulating Hormone

<p><strong><em>Introduction:</em></strong><em> iodine deficiency </em><em>disorders (IDD)</em><em> </em><em>are most common cause of preventable brain damage, mental retardation and stunted growth in children</em><em> worldwide. Several indicators are complementary to urinary iodine concentration (UIC) for assessing iodine nutritional status, as thyroid size, thyroglobulin (Tg) and thyroid stimulating hormone (TSH) concentrations in the blood.</em><strong><em> Objective:</em></strong><em> </em><em>analyze TSH in filter paper blood values and correlate with UIC in schoolchildren from public school at state of Bahia, Brazil</em><em>. <strong>Methodology: </strong></em><em>cross-sectional study was conducted in 880 schoolchildren aged 6-14 years, randomly selected, of public schools in five cities of four micro-regions of Bahia between October 2013 and September 2014. TSH was analyzed in filter-paper blood and UIC were measured by adapted Sandell-Kolthoff reaction. </em><strong><em>Results:</em></strong><em> 880 blood samples on filter-paper were analyzed for TSH. The reference range previously established is 0.72 to 6.0 </em><em>μ</em><em>UI/mL</em><em>. Results of this research TSH dosage ranged from 0.24 </em><em>μ</em><em>IU/L to</em><em> 7.71 </em><em>μ</em><em>IU/L,</em><em> with a mean of 1.01±0.55 </em><em>μ</em><em>UI/L</em><em> and median 0.89 </em><em>μ</em><em>UI/L</em><em>. Only one child presented TSH greater than 6.0 (7.71 </em><em>μ</em><em>IU/L); however, results of urinary iodine were consistent with a more than adequate nutrition iodine (243.70</em><em>μ</em><em>g/L). There’ no correlation between TSH and UIC (r= 0.115; p= 0.002)</em><em>.</em><em> </em><strong><em>Conclusion:</em></strong><em>  in the present study, schoolchildren showed low values of TSH, but the mean UIC was indicative of adequate iodine nutrition</em><em>.</em><em></em></p>

scholarly journals Iodine concentration and prevalence of thyroid disease in older people after salt iodization in Turkey

2021 ◽  
Vol 27 (2) ◽  
pp. 151-158
Author(s):  
Volkan Atmis ◽  
Buket Bülbül ◽  
Remzi Bahşi ◽  
Mesut Gümüşsoy ◽  
Ahmet Yalçin ◽  
...  
Keyword(s):  
Older People ◽  
Thyroid Disease ◽  
Demographic Data ◽  
Urinary Iodine ◽  
Iodine Concentration ◽  
Needle Aspiration ◽  
Thyroid Stimulating Hormone ◽  
Urinary Iodine Concentration ◽  
Salt Iodization ◽  
Stimulating Hormone

Background: Iodine uptake is a main factor affecting thyroid disease. In Turkey, mandatory salt iodization began in 1999–2000. Aims: This study in 2009 determined the prevalence of thyroid diseases in older people in Mamak district, Ankara after iodization to ascertain if salt iodization alone is sufficient to reach adequate iodine levels in the older population. Methods: All Mamak residents ≥ 65 years were eligible for inclusion in the study. Demographic data and medical history were recorded. All participants had a thyroid ultrasound. Blood samples were taken to assess thyroid function and autoantibodies, and urine samples to assess iodine concentration. Participants with low levels of thyroid stimulating hormone underwent scintigraphy to assess thyroid uptake. Fine-needle aspiration biopsy was done of nodules ≥ 1.5 cm where thyroid stimulating hormone was not suppressed. Results: Of 1200 eligible residents, 979 were included. Their mean age was 70.9 (standard deviation (SD) 5.7) years; 49.7% were women. Mean urinary iodine concentration was 98 (SD 81.29) µg/L. Goitre was found in 18.2% (89/487) of women and 6.7% (33/492) of men (P < 0.001) and 43.8% (428/979) had nodules. Subclinical hypothyroidism was found in 5.8% (57/979) of the participants, overt hyperthyroidism in 0.8% (8/979), subclinical hyperthyroidism in 2.2% (22/979) and T3 thyrotoxicosis in 0.3% (3/979). Toxic multinodular goitre and toxic adenoma caused 80% of hyperthyroidism cases. Biopsy detected no malignant pathology. Conclusion: After salt iodization, iodine levels have not yet reached favourable levels in older people. Iodization of salt seems insufficient to achieve these levels in older people; alternative iodine supplementation should be considered.

Circulating Levels of Immunoreactive Peptides and Steroid Hormones in Bronchogenic Carcinoma

1986 ◽  
Vol 1 (2) ◽  
pp. 93-100 ◽  
Author(s):  
Guido Francini ◽  
Pieraldo Inaudi ◽  
Giuseppe Gotti ◽  
Stefano Gonnelli ◽  
Barbara Lucani ◽  
...  
Keyword(s):  
Bronchogenic Carcinoma ◽  
Adrenocorticotropic Hormone ◽  
Human Growth ◽  
Plasma Renin ◽  
Serum Levels ◽  
Thyroid Stimulating Hormone ◽  
High Serum ◽  
Response To Therapy ◽  
Circulating Levels ◽  
Stimulating Hormone

Plasma levels of immunoreactive parathormone (iPTH), immunoreactive calcitonin (iCT) and prostaglandins (PGE2) were measured by RIA in 115 patients with bronchogenic carcinoma. In 37 of these cases the following hormones were also assayed: adrenocorticotropic hormone (ACTH), cortisol, plasma renin activity (PRA), aldosterone, prolactin, human growth hormone (HGH), thyroid stimulating hormone (TSH), luteinizing hormone (LH), follicle stimulating hormone (FSH) human chorionic gonadotropin (HCG), progesterone (P), an-drostenedoone (A), testosterone (T), estradiol (E2) and dehydropiandrosterone sulphate (DHAS). High serum levels of many hormone-like substances and hormones were found and the levels of certain hormones varied in some cases according to the clinical evolution of the disease and the response to therapy.

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