Two cases of nevus sebaceous accompanying secondary tumors with βKlotho expression

Nevus sebaceous (NS) is a benign tumor with the potential to develop secondary benign and malignant neoplasms. It is a rare phenomenon to develop 2 or more skin tumors in a single NS lesion. We report a case of multiple secondary tumors, such as sebaceoma, sebaceous carcinoma, syringocystadenoma papilliferum, and trichoblastoma, in a single NS lesion.

Download Full-text

Secondary Tumor Arising in a Nevus Sebaceous

Serbian Journal of Dermatology and Venerology ◽

10.2478/sjdv-2020-0018 ◽

2020 ◽

Vol 12 (4) ◽

pp. 147-151

Author(s):

Biljana Jeremić Gajinov ◽

Sonja Prćić ◽

Milana Ivkov Simić ◽

Nada Vučković ◽

Milan Matić ◽

...

Keyword(s):

Final Diagnosis ◽

Hair Follicles ◽

Sweat Glands ◽

Sebaceous Glands ◽

Secondary Tumor ◽

Secondary Tumors ◽

Secondary Lesion ◽

Malignant Lesions ◽

Nevus Sebaceous

Abstract Introduction. Nevus sebaceous is a rare congenital hamartoma, composed of epidermis, sebaceous glands, sweat glands and hair follicles. It is possible to develop secondary tumors in the area of nevus sebaceous during the lifetime, most often after puberty. Secondary lesions are most often benign, while malignant lesions may occur but significantly less frequently. Case report. We present the case of a 21-year-old patient who came for an examination due to the appearance of a nodule in the area of a yellowish lesion on the head. The yellowish lesion was present since birth, and the nodule appeared about a year before. The dermoscopic examination of the lesion was nonspecific. The final diagnosis of eccrine poroma as a secondary lesion in nevus sebaceous was made by pathohisto-logical analysis. Conclusion. Every secondary tumor in nevus sebaceous deserves full attention, with either close follow up, or excision with pathohistological analysis.

Download Full-text

Four Different Tumors Arising in a Nevus Sebaceous

Case Reports in Dermatology ◽

10.1159/000445822 ◽

2016 ◽

Vol 8 (1) ◽

pp. 75-79 ◽

Cited By ~ 5

Author(s):

Takeshi Namiki ◽

Keiko Miura ◽

Makiko Ueno ◽

Yumi Arima ◽

Aya Nishizawa ◽

...

Keyword(s):

Basal Cell Carcinoma ◽

Cell Carcinoma ◽

Basal Cell ◽

Histopathological Examination ◽

Lower Portion ◽

Multiple Tumors ◽

Secondary Tumors ◽

Syringocystadenoma Papilliferum ◽

Nevus Sebaceous ◽

Black Node

Nevus sebaceous is known by its association with one or more secondary tumors, but more than three multiple tumors arising from a nevus sebaceous is extremely rare. A 67-year-old female presented with a light brown plaque on the back of her head that contained a dome-shaped black node and an erosive lesion. Histopathological examination showed atypical basaloid cells in the black node. At the periphery of that node, structures resembling follicular germs extruded from interlacing cords in the upper portion and tumor nests with sebocytes were in the lower portion. In the erosive lesion, papillated structures with an apocrine epithelium were observed. In the light brown plaque, enlargement of sebaceous lobules was noted. From those histopathological features, a diagnosis of syringocystadenoma papilliferum, sebaceoma, trichoblastoma and basal cell carcinoma arising from a nevus sebaceous was made. We discuss the rarity of multiple tumors arising from a nevus sebaceous.

Download Full-text

Pathogenesis of feline leukemia virus T17: contrasting fates of helper, v-myc, and v-tcr proviruses in secondary tumors.

Journal of Virology ◽

10.1128/jvi.66.6.3538-3549.1992 ◽

1992 ◽

Vol 66 (6) ◽

pp. 3538-3549 ◽

Cited By ~ 6

Author(s):

A Terry ◽

R Fulton ◽

M Stewart ◽

D E Onions ◽

J C Neil

Keyword(s):

Leukemia Virus ◽

Feline Leukemia Virus ◽

Secondary Tumors

Download Full-text

Secondary Tumors in Bone Sarcomas After Treatment with Chemotherapy

Cancer Detection and Prevention ◽

10.1046/j.1525-1500.1999.99044.x ◽

1999 ◽

Vol 23 (5) ◽

pp. 368-374 ◽

Cited By ~ 20

Author(s):

C. Ferrari ◽

T. Bohling ◽

M. S. Benassi ◽

A. Ferraro ◽

G. Gamberi ◽

...

Keyword(s):

Secondary Tumors ◽

Bone Sarcomas

Download Full-text

Impairing flow-mediated endothelial remodeling reduces extravasation of tumor cells

Scientific Reports ◽

10.1038/s41598-021-92515-2 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Gautier Follain ◽

Naël Osmani ◽

Valentin Gensbittel ◽

Nandini Asokan ◽

Annabel Larnicol ◽

...

Keyword(s):

Blood Flow ◽

Tumor Cells ◽

Molecular Mechanisms ◽

Metastatic Progression ◽

Metastatic Dissemination ◽

Secondary Tumors ◽

Flow Profiles ◽

Endothelial Response ◽

Life Threatening

AbstractTumor progression and metastatic dissemination are driven by cell-intrinsic and biomechanical cues that favor the growth of life-threatening secondary tumors. We recently identified pro-metastatic vascular regions with blood flow profiles that are permissive for the arrest of circulating tumor cells. We have further established that such flow profiles also control endothelial remodeling, which favors extravasation of arrested CTCs. Yet, how shear forces control endothelial remodeling is unknown. In the present work, we aimed at dissecting the cellular and molecular mechanisms driving blood flow-dependent endothelial remodeling. Transcriptomic analysis of endothelial cells revealed that blood flow enhanced VEGFR signaling, among others. Using a combination of in vitro microfluidics and intravital imaging in zebrafish embryos, we now demonstrate that the early flow-driven endothelial response can be prevented upon specific inhibition of VEGFR tyrosine kinase and subsequent signaling. Inhibitory targeting of VEGFRs reduced endothelial remodeling and subsequent metastatic extravasation. These results confirm the importance of VEGFR-dependent endothelial remodeling as a driving force of CTC extravasation and metastatic dissemination. Furthermore, the present work suggests that therapies targeting endothelial remodeling might be a relevant clinical strategy in order to impede metastatic progression.

Download Full-text

The Role of KRAS Mutations in Cortical Malformation and Epilepsy Surgery: A Novel Report of Nevus Sebaceous Syndrome and Review of the Literature

Brain Sciences ◽

10.3390/brainsci11060793 ◽

2021 ◽

Vol 11 (6) ◽

pp. 793

Author(s):

Chiara Pepi ◽

Luca de Palma ◽

Marina Trivisano ◽

Nicola Pietrafusa ◽

Francesca Romana Lepri ◽

...

Keyword(s):

Epilepsy Surgery ◽

Focal Cortical Dysplasia ◽

Hippocampal Sclerosis ◽

Brain Mri ◽

Seizure Freedom ◽

Histopathological Diagnosis ◽

Cortical Malformation ◽

Cognitive Improvement ◽

Cortical Malformations ◽

Nevus Sebaceous

The rare nevus sebaceous (NS) syndrome (NSS) includes cortical malformations and drug-resistant epilepsy. Somatic RAS-pathway genetic variants are pathogenetic in NS, but not yet described within the brain of patients with NSS. We report on a 5-year-old boy with mild psychomotor delay. A brown-yellow linear skin lesion suggestive of NS in the left temporo-occipital area was evident at birth. Epileptic spasms presented at aged six months. EEG showed continuous left temporo-occipital epileptiform abnormalities. Brain MRI revealed a similarly located diffuse cortical malformation with temporal pole volume reduction and a small hippocampus. We performed a left temporo-occipital resection with histopathological diagnosis of focal cortical dysplasia type Ia in the occipital region and hippocampal sclerosis type 1. Three years after surgery, he is seizure-and drug-free (Engel class Ia) and showed cognitive improvement. Genetic examination of brain and skin specimens revealed the c.35G > T (p.Gly12Val) KRAS somatic missense mutation. Literature review suggests epilepsy surgery in patients with NSS is highly efficacious, with 73% probability of seizure freedom. The few histological analyses reported evidenced disorganized cortex, occasionally with cytomegalic neurons. This is the first reported association of a KRAS genetic variant with cortical malformations associated with epilepsy, and suggests a possible genetic substrate for hippocampal sclerosis.

Download Full-text