Oxytocin in the regulation of social behaviours in medial amygdala-lesioned mice via the inhibition of the extracellular signal-regulated kinase signalling pathway

2015 ◽  
Vol 42 (5) ◽  
pp. 465-474 ◽  
Author(s):  
Yu Wang ◽  
Shanshan Zhao ◽  
Zhe Wu ◽  
Yu Feng ◽  
Chuansheng Zhao ◽  
...  
Keyword(s):  
Signalling Pathway ◽  
Medial Amygdala ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Social Behaviours

Regulation of MEK/ERK pathway output by subcellular localization of B-Raf

2012 ◽  
Vol 40 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Catherine Andreadi ◽  
Catherine Noble ◽  
Bipin Patel ◽  
Hong Jin ◽  
Maria M. Aguilar Hernandez ◽  
...  
Keyword(s):  
Growth Factor ◽  
Subcellular Localization ◽  
Signalling Pathway ◽  
Erk Activation ◽  
Extracellular Signal Regulated Kinase ◽  
Intracellular Signalling Pathway ◽  
Pathway Activation ◽  
Extracellular Signal ◽  
A Cell ◽  
Phase Entry

The strength and duration of intracellular signalling pathway activation is a key determinant of the biological outcome of cells in response to extracellular cues. This has been particularly elucidated for the Ras/Raf/MEK [mitogen-activated growth factor/ERK (extracellular-signal-regulated kinase) kinase]/ERK signalling pathway with a number of studies in fibroblasts showing that sustained ERK signalling is a requirement for S-phase entry, whereas transient ERK signalling does not have this capability. A major unanswered question, however, is how a cell can sustain ERK activation, particularly when ERK-specific phosphatases are transcriptionally up-regulated by the pathway itself. A major point of ERK regulation is at the level of Raf, and, to sustain ERK activation in the presence of ERK phosphatases, sustained Raf activation is a requirement. Three Raf proteins exist in mammals, and the activity of all three is induced following growth factor stimulation of cells, but only B-Raf activity is maintained at later time points. This observation points to B-Raf as a regulator of sustained ERK activation. In the present review, we consider evidence for a link between B-Raf and sustained ERK activation, focusing on a potential role for the subcellular localization of B-Raf in this key physiological event.

Xanthohumol inhibits the extracellular signal regulated kinase (ERK) signalling pathway and suppresses cell growth of lung adenocarcinoma cells

Toxicology ◽  
2016 ◽  
Vol 357-358 ◽  
pp. 65-73 ◽  
Author(s):  
Adrianna Sławińska-Brych ◽  
Barbara Zdzisińska ◽  
Magdalena Dmoszyńska-Graniczka ◽  
Witold Jeleniewicz ◽  
Jacek Kurzepa ◽  
...  
Keyword(s):  
Cell Growth ◽  
Lung Adenocarcinoma ◽  
Signalling Pathway ◽  
Extracellular Signal Regulated Kinase ◽  
Extracellular Signal ◽  
Adenocarcinoma Cells ◽  
Lung Adenocarcinoma Cells
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