The changes of individual carotid artery wall layer by aging and carotid intima-media thickness value for high risk

Hypertension is a major risk factor for progression of the atherosclerotic process and for developing of degenerative cardiovascular diseases in adulthood. The aim of this study is to evaluate how the measurement of carotid intima - media thickness for prediction of essential hypertension in children can be used.The study group included 81 children and the control group 61 children, all aged between 5 - 17 years and 11 months old, and admitted in Children Hospital Brasov in the period of 2009 � 2014. The study protocol included: BMI, blood pressure and Doppler echography of the common carotid artery for each group. Mean age of the patients from the study group was 13.67 years, 43.20 % girls and 56.80 % boys, while in the control group, the mean age was 14.07 years, 54.10% girls and 45.90 % boys. 70.37% of the children from the study group presented obesity, while in the control group 40.98% were obese. The IMTC study group ranged from 0.52 - 0.69 mm and the limits of the normotensive subjects were 0.32 -0.54 mm. In both groups the obese patients were found to have increased carotid artery intima-media, which means that IMTC was positively correlated with BMI (p=0.000001).It is necessary to identify diagnostic methods easily applicable for children, allowing involvement of the characteristics of the arterial wall in the degenerative pathological processes. Increased intima-media ratio is positively correlated with high values of blood pressure.

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Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study

European Journal of Obstetrics & Gynecology and Reproductive Biology ◽

10.1016/j.ejogrb.2021.01.016 ◽

2021 ◽

Vol 258 ◽

pp. 288-293

Author(s):

Tansim Akhter ◽

Gerhard Wikström ◽

Marita Larsson ◽

Ulf Bondesson ◽

Mikael Hedeland ◽

...

Keyword(s):

Risk Factors ◽

Cardiovascular Risk ◽

Carotid Artery ◽

Comparative Study ◽

Pregnant Women ◽

Cardiovascular Risk Factors ◽

Common Carotid Artery ◽

Wall Layer ◽

Artery Wall ◽

Carotid Artery Wall

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Sitagliptin on carotid intima-media thickness in type 2 diabetes and hyperuricemia patients: a subgroup analysis of the PROLOGUE study

Therapeutic Advances in Chronic Disease ◽

10.1177/20406223211026993 ◽

2021 ◽

Vol 12 ◽

pp. 204062232110269

Author(s):

Yipin Zhao ◽

Huawei Wang ◽

Dazhi Ke ◽

Wei Deng ◽

Yingying Ji ◽

...

Keyword(s):

Type 2 Diabetes ◽

Carotid Artery ◽

Conventional Therapy ◽

Therapy Group ◽

Controlled Trial ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Media Thickness ◽

Significant Difference

Background and Aims: Studies have shown that dipeptidyl peptidase-4 (DDP-4) inhibitors have anti-atherosclerotic effects. However, in the PROLOGUE study, sitagliptin failed to slow the progression of carotid intima-media thickness (CIMT) relative to conventional therapy. We conducted a post hoc analysis of the PROLOGUE study and compared the effects of sitagliptin and conventional therapy on changes in CIMT in subgroups with or without hyperuricemia. Methods: The PROLOGUE study was a randomized controlled trial of 442 patients with type 2 diabetes mellitus (T2DM). Patients were randomized to receive sitagliptin added therapy or conventional therapy. Based on the serum uric acid levels of all study populations in the PROLOGUE study, we divided them into hyperuricemia subgroup ( n = 104) and non-hyperuricemia subgroup ( n = 331). The primary outcome was changed in carotid intima-media thickness (CIMT) parameters compared with baseline during the 24 months treatment period. Results: In the hyperuricemia subgroup, compared with the conventional therapy group, the changes in the mean internal carotid artery (ICA)-IMT and max ICA-IMT at 24 months were significantly lower in the sitagliptin group [−0.233 mm, 95% confidence interval (CI) (−0.419 to 0.046), p = 0.015 and −0.325 mm, 95% CI (−0.583 to −0.068), p = 0.014], although there was no significant difference in the common carotid artery CIMT. Conclusion: The results of our analysis indicated that sitagliptin attenuated the progression of CIMT than conventional therapy in T2DM and hyperuricemia patients.

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Carotid Intima‐Media Thickness and the Risk of Sudden Cardiac Death: The ARIC Study and the CHS

Journal of the American Heart Association ◽

10.1161/jaha.120.016981 ◽

2020 ◽

Vol 9 (19) ◽

Author(s):

Takeki Suzuki ◽

Wanmei Wang ◽

Anthony Wilsdon ◽

Kenneth R. Butler ◽

Selcuk Adabag ◽

...

Keyword(s):

Sudden Cardiac Death ◽

Carotid Artery ◽

Common Carotid Artery ◽

Cardiac Death ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Cardiovascular Health Study ◽

Media Thickness ◽

Increased Risk ◽

Aric Study

Background Sudden cardiac death (SCD) is associated with severe coronary heart disease in the great majority of cases. Whether carotid intima‐media thickness (C‐IMT), a known surrogate marker of subclinical atherosclerosis, is associated with risk of SCD in a general population remains unknown. The objective of this study was to investigate the association between C‐IMT and risk of SCD. Methods and Results We examined a total of 20 862 participants: 15 307 participants of the ARIC (Atherosclerosis Risk in Communities) study and 5555 participants of the CHS (Cardiovascular Health Study). C‐IMT and common carotid artery intima‐media thickness was measured at baseline by ultrasound. Presence of plaque was judged by trained readers. Over a median of 23.5 years of follow‐up, 569 participants had SCD (1.81 cases per 1000 person‐years) in the ARIC study. Mean C‐IMT and common carotid artery intima‐media thickness were associated with risk of SCD after adjustment for traditional risk factors and time‐varying adjustors: hazard ratios (HRs) with 95% CIs for fourth versus first quartile were 1.64 (1.15–2.63) and 1.49 (1.05–2.11), respectively. In CHS, 302 participants developed SCD (4.64 cases per 1000 person‐years) over 13.1 years. Maximum C‐IMT was associated with risk of SCD after adjustment: HR (95% CI) for fourth versus first quartile was 1.75 (1.22–2.51). Presence of plaque was associated with 35% increased risk of SCD: HR (95% CI) of 1.37 (1.13–1.67) in the ARIC study and 1.32 (1.04–1.68) in CHS. Conclusions C‐IMT was associated with risk of SCD in 2 biracial community‐based cohorts. C‐IMT may be used as a marker of SCD risk and potentially to initiate early therapeutic interventions to mitigate the risk.

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Cardiorespiratory Fitness and Carotid Artery Intima Media Thickness in Men With Type 2 Diabetes

Journal of Physical Activity and Health ◽

10.1123/jpah.9.4.549 ◽

2012 ◽

Vol 9 (4) ◽

pp. 549-553 ◽

Cited By ~ 8

Author(s):

Sae Young Jae ◽

Kevin Heffernan ◽

Bo Fernhall ◽

Yoon-Ho Choi

Keyword(s):

Type 2 Diabetes ◽

Carotid Artery ◽

Cardiorespiratory Fitness ◽

Carotid Atherosclerosis ◽

Intima Media Thickness ◽

Carotid Intima Media Thickness ◽

Peak Oxygen Uptake ◽

Media Thickness ◽

Multivariable Regression

Background:We tested the hypothesis that higher levels of cardiorespiratory fitness are inversely associated with carotid artery intima media thickness in 746 (age 53 ± 7 yrs) men with type 2 diabetes.Methods:We measured common carotid intima media thickness and defined carotid atherosclerosis as a carotid intima media thickness > 1.0 mm. Cardiorespiratory fitness was directly measured by peak oxygen uptake using expired gases analysis during a standard treadmill test.Results:Cardiorespiratory fitness was independently associated with common carotid intima media thickness in multivariable regression (β = –0.15, P < .05). After adjusting for established risk factors, high and moderate cardiorespiratory fitness were associated with lower odds ratios for having carotid atherosclerosis—0.49 (95% CI, 0.30–0.81), and 0.59 (95% CI, 0.38–0.92), respectively—as compared with low cardiorespiratory fitness. Each 1 metabolic equivalent increment higher cardiorespiratory fitness was associated with 27% (OR = 0.73; 95% CI, 0.61–0.87) lower prevalence of carotid atherosclerosis.Conclusions:These results suggest that high cardiorespiratory fitness is inversely associated with common carotid intima media thickness in men with type 2 diabetes.

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