Prevalence and risk factors of systemic sclerosis‐associated interstitial lung disease in East Asia: A systematic review and meta‐analysis

Several retrospectivee described the association of interstitial lung disease (ILD) and ANCA-associated vasculitis (AAV). However, the relationship between the ILD and mortality in AAV patients have not been established so far. This study aims to estimate the relevance of AAV-associated-ILD (AAV-ILD) and mortality risk by conducting a systematic review and meta-analysis.A comprehensive systematic review was conducted in accordance with the guidelines of PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses). PubMed, Embase.com and the Cochrane Library (Wiley) were searched for original observational studies. Summary estimates were derived with a random-effects model and reported as risk ratio (RR), tested for publication bias and heterogeneity. Ten retrospective cohort studies were included, comprising 526 AAV-ILD patients enrolled from 1974 to 2018. Meta-analysis yielded a pooled RR of 2.90 (95% confidence interval 1.77–4.74) for death among those with AAV-ILD compared to control group. UIP pattern was associated with an even poorer prognosis in comparison to non-UIP pattern (RR 4.36, 95% confidence interval 1.14–16.78). Sensitivity analysis suggested that the meta-RR result was not skewed by a single dominant study. ILD might be associated with a higher mortality risk in AAV patients.

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Correction to: The prevalence of obstructive sleep apnea in interstitial lung disease: a systematic review and meta-analysis

Sleep And Breathing ◽

10.1007/s11325-021-02354-8 ◽

2021 ◽

Author(s):

Yang Cheng ◽

Yan Wang ◽

Li Dai

Keyword(s):

Systematic Review ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Meta Analysis ◽

Obstructive Sleep

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The Association between MUC5B Rs35705950 and Risks of Idiopathic Interstitial Pneumonia, Systemic Sclerosis Interstitial Lung Disease, and Familial Interstitial Pneumonia: A Meta-Analysis

Iranian Journal of Public Health ◽

10.18502/ijph.v49i12.4801 ◽

2020 ◽

Author(s):

Huai-Qing LOU ◽

Chun-Xia HUANG ◽

Guang-Yi LI ◽

Ping LI ◽

Shou-Ming ZHANG ◽

...

Keyword(s):

Systemic Sclerosis ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Interstitial Pneumonia ◽

Lung Diseases ◽

Meta Analysis ◽

Biomedical Literature ◽

Idiopathic Interstitial Pneumonia ◽

Normal Lung ◽

Cochrane Central Register

Background: Interstitial lung disease (ILD) is a category of chronic lung diseases with more than 200 subtypes. Idiopathic interstitial pneumonia (IIP), systemic sclerosis (SSc) ILD, and familial interstitial pneumonia (FIP) are three major groups of lung diseases with different causes or with unknown causes. Mucin5B (MUC5B) belongs to the mucin family, which contribute to the lubricating and viscoelastic properties of the whole saliva, normal lung mucus, and cervical mucus. The association between MUC5B rs35705950 and ILDs risks has been widely studied. However, the results were inconclusive and inconsistent. Methods: In the present meta-analysis, the database PubMed, Embase, Cochrane Central Register of Controlled Trials, CNKI and Chinese Biomedical Literature Database were searched till Aug 20th, 2018. Overall 16 publications with 28 studies, 76345 cases and 18402 controls were included. Results: The results indicated a significant increase of overall IIP risk for TT genotype and T allele of the rs35705950 in all genetic models (TT vs GG, OR=9.11; TT vs GT+TT, OR=5.80; GT+TT vs GG, OR=4.34; T vs G, OR=4.03. P<0.0001). Subgroup analysis by subtypes of IIP revealed higher risks of TT genotype and T allele for IPF and iNSIP (P<0.05). A significant increase of FIP risk was also found for the TT genotype and T allele of the rs35705950 (TT vs GG, OR=17.08; GT+TT vs GG, OR=6.02; T vs G, OR=1.64.P<0.05). Conclusion: No significant relations existed between the rs35705950 and SSc-ILD risks. MUC5B rs35705950 might be a predictor for the susceptibility of IIP and FIP.

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Factors Associated with Interstitial Lung Disease in Patients with Polymyositis and Dermatomyositis: A Systematic Review and Meta-Analysis

PLoS ONE ◽

10.1371/journal.pone.0155381 ◽

2016 ◽

Vol 11 (5) ◽

pp. e0155381 ◽

Cited By ~ 26

Author(s):

Li Zhang ◽

Guoqin Wu ◽

Di Gao ◽

Guijian Liu ◽

Lin Pan ◽

...

Keyword(s):

Systematic Review ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Meta Analysis ◽

Factors Associated

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Pulmonary function tests as outcomes for systemic sclerosis interstitial lung disease

European Respiratory Review ◽

10.1183/16000617.0102-2017 ◽

2018 ◽

Vol 27 (148) ◽

pp. 170102 ◽

Cited By ~ 15

Author(s):

Melissa Caron ◽

Sabrina Hoa ◽

Marie Hudson ◽

Kevin Schwartzman ◽

Russell Steele

Keyword(s):

Systematic Review ◽

Systemic Sclerosis ◽

Interstitial Lung Disease ◽

Pulmonary Function ◽

Lung Disease ◽

Validation Studies ◽

Pulmonary Function Tests ◽

Outcome Studies ◽

Surrogate Markers ◽

Function Tests

Interstitial lung disease (ILD) is the leading cause of morbidity and mortality in systemic sclerosis (SSc). We performed a systematic review to characterise the use and validation of pulmonary function tests (PFTs) as surrogate markers for systemic sclerosis-associated interstitial lung disease (SSc-ILD) progression.Five electronic databases were searched to identify all relevant studies. Included studies either used at least one PFT measure as a longitudinal outcome for SSc-ILD progression (i.e. outcome studies) and/or reported at least one classical measure of validity for the PFTs in SSc-ILD (i.e. validation studies).This systematic review included 169 outcome studies and 50 validation studies. Diffusing capacity of the lung for carbon monoxide (DLCO) was cumulatively the most commonly used outcome until 2010 when it was surpassed by forced vital capacity (FVC). FVC (% predicted) was the primary endpoint in 70.4% of studies, compared to 11.3% for % predicted DLCO. Only five studies specifically aimed to validate the PFTs: two concluded that DLCO was the best measure of SSc-ILD extent, while the others did not favour any PFT. These studies also showed respectable validity measures for total lung capacity (TLC).Despite the current preference for FVC, available evidence suggests that DLCO and TLC should not yet be discounted as potential surrogate markers for SSc-ILD progression.

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Treatment of idiopathic inflammatory myositis associated interstitial lung disease: A systematic review and meta-analysis

Autoimmunity Reviews ◽

10.1016/j.autrev.2018.07.013 ◽

2019 ◽

Vol 18 (2) ◽

pp. 113-122 ◽

Cited By ~ 27

Author(s):

Thomas Barba ◽

Romain Fort ◽

Vincent Cottin ◽

Steeve Provencher ◽

Isabelle Durieu ◽

...

Keyword(s):

Systematic Review ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Meta Analysis ◽

Inflammatory Myositis ◽

Idiopathic Inflammatory Myositis

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Systematic review and meta-analysis of prognostic factors for idiopathic inflammatory myopathy-associated interstitial lung disease

BMJ Open ◽

10.1136/bmjopen-2018-023998 ◽

2018 ◽

Vol 8 (12) ◽

pp. e023998 ◽

Cited By ~ 7

Author(s):

Hiroyuki Kamiya ◽

Ogee Mer Panlaqui ◽

Shinyu Izumi ◽

Takashi Sozu

Keyword(s):

Systematic Review ◽

Prognostic Factors ◽

Interstitial Lung Disease ◽

Lung Disease ◽

Evaluation System ◽

Meta Analysis ◽

Inflammatory Myopathy ◽

Idiopathic Inflammatory Myopathy ◽

All Cause Mortality ◽

Radiological Abnormality

ObjectiveTo clarify prognostic factors for idiopathic inflammatory myopathy (IIM)-associated interstitial lung disease (ILD).DesignSystematic review and meta-analysis using the Grades of Recommendation, Assessment, Development and Evaluation system.Data sourcesMedline, EMBASE and Science Citation Index Expanded were searched through 9 August 2018.Eligibility criteria for selecting studiesThe review includes primary studies addressing all-cause mortality of IIM-associated ILD. Potential prognostic factors were any clinical information related to the outcome.Data extraction and synthesisTwo reviewers extracted relevant data independently and assessed risk of bias using the Quality in Prognostic Studies tool. Meta-analysis was conducted using a random effects model and if inappropriate the results were reported qualitatively. Prognostic factors were determined based on statistically significant results derived from multivariate analysis.ResultsOf a total of 5892 articles returned, 32 were deemed eligible for analysis and cumulatively, these studies reported 28 potential prognostic factors for all-cause mortality. Each study was subject to certain methodological constraints. The four prognostic factors, which demonstrated statistically significant results on both univariate and multivariate analyses, were as follows: age (MD 5.90, 3.17–8.63/HR 1.06, 1.02–1.10 and 2.31, 1.06–5.06), acute/subacute interstitial pneumonia (A/SIP) (OR 4.85, 2.81–8.37/HR 4.23, 1.69–12.09 and 5.17, 1.94–13.49), percentage of predicted forced vital capacity (%FVC) (OR 0.96, 0.95–0.98/HR 0.96, 0.93–0.99) and anti-Jo-1 antibody (OR 0.35, 0.18–0.71/HR 0.004, 0.00003–0.54) (univariate/multivariate, 95% CI). Other prognostic factors included ground glass opacity/attenuation (GGO/GGA) and extent of radiological abnormality. The quality of the presented evidence was rated as either low or very low.ConclusionsOlder age, A/SIP, lower value of %FVC, GGO/GGA and extent of radiological abnormality were demonstrated to predict poor prognosis for IIM-associated ILD while a positive test for anti-Jo-1 antibody indicated better prognosis. However, given the weak evidence they should be interpreted with caution.Trial registration numberCRD42016036999.

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