Determinants of Blood Brain-Derived Neurotrophic Factor Blood Levels in Patients with Alcohol Use Disorder

2017 ◽  
Vol 41 (7) ◽  
pp. 1280-1287 ◽  
Author(s):  
Philippe Nubukpo ◽  
Nicolas Ramoz ◽  
Murielle Girard ◽  
Dominique Malauzat ◽  
Philip Gorwood
Keyword(s):  
Alcohol Use ◽  
Neurotrophic Factor ◽  
Alcohol Use Disorder ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Levels ◽  
Blood Brain

scholarly journals Human Plasma BDNF Is Associated With Amygdala-Prefrontal Cortex Functional Connectivity and Problem Drinking Behaviors

2019 ◽  
Vol 23 (1) ◽  
pp. 1-11
Author(s):  
Stephanie M Gorka ◽  
Tara Teppen ◽  
Milena Radoman ◽  
K Luan Phan ◽  
Subhash C Pandey
Keyword(s):  
Prefrontal Cortex ◽  
Individual Differences ◽  
Functional Connectivity ◽  
Alcohol Use ◽  
Medial Prefrontal Cortex ◽  
Neurotrophic Factor ◽  
Alcohol Use Disorder ◽  
Brain Derived Neurotrophic Factor ◽  
Drinking Behaviors ◽  
Threat Of Shock

Abstract Background Preclinical studies suggest that decreased levels of brain-derived neurotrophic factor in the amygdala play a role in anxiety and alcohol use disorder. The association between brain-derived neurotrophic factor levels and amygdala function in humans with alcohol use disorder is still unclear, although neuroimaging studies have also implicated the amygdala in alcohol use disorder and suggest that alcohol use disorder is associated with disrupted functional connectivity between the amygdala and prefrontal cortex during aversive states. Methods The current study investigated whether plasma brain-derived neurotrophic factor levels in individuals with and without alcohol use disorder (n = 57) were associated with individual differences in amygdala reactivity and amygdala-prefrontal cortex functional connectivity during 2 forms of aversive responding captured via functional magnetic resonance imaging: anxiety elicited by unpredictable threat of shock and fear elicited by predictable threat of shock. We also examined whether brain-derived neurotrophic factor and brain function were associated with binge drinking episodes and alcohol use disorder age of onset. Results During anxiety, but not fear, lower levels of plasma brain-derived neurotrophic factor were associated with less connectivity between the left amygdala and the medial prefrontal cortex and the inferior frontal gyrus. In addition, within individuals with alcohol use disorder (only), lower levels of brain-derived neurotrophic factor and amygdala-medial prefrontal cortex functional connectivity during anxiety were associated with more binge episodes within the past 60 days and a lower age of alcohol use disorder onset. There were no associations between brain-derived neurotrophic factor levels and focal amygdala task reactivity. Conclusions Together, the results indicate that plasma brain-derived neurotrophic factor levels are related to amygdala circuit functioning in humans, particularly during anxiety, and these individual differences may relate to drinking behaviors.

Circulating Brain-Derived Neurotrophic Factor as a potential biomarker in stroke: a Systematic review and Meta-analysis

2021 ◽  
Author(s):  
Helia Mojtabavi ◽  
Zoha Shaka ◽  
Sara Momtazmanesh ◽  
Atra Ajdari ◽  
Nima Rezaei
Keyword(s):  
Physical Training ◽  
Neurotrophic Factor ◽  
Neuronal Damage ◽  
Meta Analysis ◽  
Brain Derived Neurotrophic Factor ◽  
Blood Levels ◽  
Cerebrovascular Event ◽  
Medical Databases ◽  
Potential Biomarker ◽  
Significant Difference

Abstract Background Stroke, an acute cerebrovascular event, is a leading cause of disability, placing a significant psycho-socioeconomic burden worldwide. Neuroplasticity is adaptation and reorganization following neuronal damage. Brain-derived neurotrophic factor (BDNF) is a neurotrophin coordinating neuroplasticity after various neurological disorders such as stroke. Methods We conducted a systematic search in the main electronic medical databases through January 2021 and identified studies that measured blood levels of BDNF in patients with stroke. The primary aim was to compare BDNF levels between patients with stroke and healthy controls (HC). The secondary aims included investigation of (1) longitudinal changes in the BDNF levels post-stroke, (2) effects of physical training, (3) repeated transcranial magnetic stimulation (rTMS), and presence of depression on BDNF levels in patients with stroke. Results Among 6243 reviewed records from PubMed, Web of Science, and Scopus, 62 studies were eligible for inclusion. Subjects with stroke, n = 1856, showed lower BDNF levels compared to HC, n=1191 (SMD [95%CI] = -1.04 [-1.49 to -0.58]). No significant difference was detected in the level of BDNF through time points past stroke. BDNF levels were lower in the patients with depression compared to non-depressed subjects (SMD [95%CI] = -0.60 [-1.10 to -0.10]). Physical training had an immediate positive effect on the BDNF levels and not statistically significant effect in the long term; SMD [95%CI] = 0.49 [0.09 to 0.88]) and SMD [95%CI] = 0.02 [-0.43 to 0.47]). Lastly, rTMS showed no effect on the level of BDNF with 0.00 SMD. Conclusions This study confirms that stroke significantly affects the level of BDNF in various domains such as cognition, affect, and motor function. We believe that BDNF could be regarded as a valuable diagnostic biomarker for acute stroke and a potential prognostic biomarker for depression and cognitive deficits.

Transport of brain-derived neurotrophic factor across the blood–brain barrier

1998 ◽  
Vol 37 (12) ◽  
pp. 1553-1561 ◽  
Author(s):  
Weihong Pan ◽  
William A Banks ◽  
Melita B Fasold ◽  
Jonathan Bluth ◽  
Abba J Kastin
Keyword(s):  
Blood Brain Barrier ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Brain Barrier ◽  
Blood Brain
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