Effects of alcohol sensitivity on alcohol‐induced blackouts and passing out: An examination of the alcohol sensitivity questionnaire among underage drinkers

2021 ◽  
Author(s):  
Christal N. Davis ◽  
Thomas M. Piasecki ◽  
Bruce D. Bartholow ◽  
Wendy S. Slutske
Keyword(s):  
Alcohol Sensitivity

scholarly journals An exploratory assessment of the applicability of direct-to-consumer genetic testing to translational research in Japan

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Masahiro Inoue ◽  
Shota Arichi ◽  
Tsuyoshi Hachiya ◽  
Anna Ohtera ◽  
Seok-Won Kim ◽  
...  
Keyword(s):  
Genetic Testing ◽  
Translational Research ◽  
Drug Target ◽  
Target Genes ◽  
Healthy Individuals ◽  
Alcohol Sensitivity ◽  
Direct To Consumer ◽  
Disease States ◽  
Multiple Phenotypes ◽  
Related Phenotype

Abstract Objective In order to assess the applicability of a direct-to-consumer (DTC) genetic testing to translational research for obtaining new knowledge on relationships between drug target genes and diseases, we examined possibility of these data by associating SNPs and disease related phenotype information collected from healthy individuals. Results A total of 12,598 saliva samples were collected from the customers of commercial service for SNPs analysis and web survey were conducted to collect phenotype information. The collected dataset revealed similarity to the Japanese data but distinguished differences to other populations of all dataset of the 1000 Genomes Project. After confirmation of a well-known relationship between ALDH2 and alcohol-sensitivity, Phenome-Wide Association Study (PheWAS) was performed to find association between pre-selected drug target genes and all the phenotypes. Association was found between GRIN2B and multiple phenotypes related to depression, which is considered reliable based on previous reports on the biological function of GRIN2B protein and its relationship with depression. These results suggest possibility of using SNPs and phenotype information collected from healthy individuals as a translational research tool for drug discovery to find relationship between a gene and a disease if it is possible to extract individuals in pre-disease states by properly designed questionnaire.

Etomidate and propofol-hyposensitive GABAA receptor β3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal

2007 ◽  
Vol 416 (3) ◽  
pp. 275-278 ◽  
Author(s):  
Carles Sanchis-Segura ◽  
Brandon Cline ◽  
Rachel Jurd ◽  
Uwe Rudolph ◽  
Rainer Spanagel
Keyword(s):  
Gabaa Receptor ◽  
Alcohol Sensitivity

Association of ALDH2 Genotypes with Periodontitis Progression

2009 ◽  
Vol 89 (2) ◽  
pp. 138-142 ◽  
Author(s):  
N. Nishida ◽  
M. Tanaka ◽  
S. Sekine ◽  
T. Takeshita ◽  
K. Nakayama ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Periodontal Disease ◽  
Disease Progression ◽  
Odds Ratio ◽  
Alcohol Sensitivity ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Significant Odds Ratio ◽  
Progression Risk ◽  
Prospective Association

The progression of periodontitis may be affected by ALDH2 genotypes with respect to the oxidation of acetaldehyde to acetate, which leads to the accumulation of acetaldehyde in plasma and potential toxic effects. We examined the prospective association of ALDH2 genotypes in terms of alcohol sensitivity between alcohol consumption and periodontal disease progression. In 2003, 224 of 256 (87.5%) individuals examined at baseline (1999) completed probing pocket depth measurements for the evaluation of periodontitis progression. Missing data on self-reported questionnaires and blood samples were excluded; therefore, 183 samples were analyzed. Individuals who consumed ≥ 33.0 g/day of alcohol exhibited high periodontal disease progression risk (OR = 3.54). ALDH2 *1/*2 individuals who consumed ≥ 33 g/day of alcohol displayed a significant odds ratio (OR = 4.28) of periodontitis progression risk, in contrast to ALDH2 *1/*1 individuals. These results suggested that alcohol consumption as well as alcohol sensitivity may be a risk factor for periodontitis progression.

scholarly journals Prion Protein Is a Key Determinant of Alcohol Sensitivity through the Modulation of N-Methyl-D-Aspartate Receptor (NMDAR) Activity

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34691 ◽  
Author(s):  
Agnès Petit-Paitel ◽  
Baptiste Ménard ◽  
Alice Guyon ◽  
Vincent Béringue ◽  
Jean-Louis Nahon ◽  
...  
Keyword(s):  
Prion Protein ◽  
Alcohol Sensitivity ◽  
Aspartate Receptor

scholarly journals Transcriptomic analyses of gastrulation-stage C57BL/6J and C57BL/6NHsd mouse embryos with differential susceptibility to alcohol

2021 ◽  
Author(s):  
Karen E. Boschen ◽  
Travis S. Ptacek ◽  
Matthew E. Berginski ◽  
Jeremy M. Simon ◽  
Scott E. Parnell
Keyword(s):  
Gene Expression ◽  
Gene Networks ◽  
Fetal Alcohol Spectrum Disorders ◽  
Prenatal Alcohol Exposure ◽  
Expression Patterns ◽  
Differential Susceptibility ◽  
Alcohol Exposure ◽  
Health Concern ◽  
Mouse Strains ◽  
Alcohol Sensitivity

Fetal Alcohol Spectrum Disorders (FASD) are a serious public health concern, affecting approximately 5% of live births in the US. The more severe craniofacial and central nervous system malformations characteristic of FASD are caused by alcohol exposure during gastrulation (embryonic day 7 in mice; 3rd week of human pregnancy). Genetics are a known contributor to differences in alcohol sensitivity in humans and in animal models of FASD. Our study profiled gene expression in gastrulation-stage embryos from two commonly used, genetically similar mouse substrains, C57BL/6J and C57BL/6NHsd, that differ in alcohol sensitivity. First, we established normal gene expression patterns at three finely resolved timepoints during gastrulation and developed a web-based interactive tool. Baseline transcriptional differences across strains were associated with immune signaling, indicative of their molecular divergence. Second, we examined the gene networks impacted by alcohol in each strain. Alcohol was associated with a more pronounced transcriptional effect in the 6J's vs. 6N's, matching the 6J's increased susceptibility. The 6J strain exhibited down-regulation of cell proliferation and morphogenic signaling pathways and up-regulation of pathways related to cell death and craniofacial defects, while 6N's show enrichment of hypoxia (up) and cellular metabolism (down) pathways. Collectively, these datasets 1) provide insight into the changing transcriptional landscape across gastrulation in two commonly used mouse strains, 2) establish a valuable resource that enables the discovery of candidate genes that may modify susceptibility to prenatal alcohol exposure that can be validated in humans, and 3) identify novel pathogenic mechanisms potentially involved in alcohol's impact on development.

Circadian Modulation of Acute Alcohol Sensitivity But Not Acute Tolerance inDrosophila

2011 ◽  
Vol 28 (5) ◽  
pp. 397-406 ◽  
Author(s):  
Kim van der Linde ◽  
Lisa C. Lyons
Keyword(s):  
Acute Tolerance ◽  
Alcohol Sensitivity
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