An association study revealed substantial effects of dominance, epistasis and substance dependence co-morbidity on alcohol dependence symptom count

2016 ◽  
Vol 22 (6) ◽  
pp. 1475-1485 ◽  
Author(s):  
Gang Chen ◽  
Futao Zhang ◽  
Wenda Xue ◽  
Ruyan Wu ◽  
Haiming Xu ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Association Study ◽  
Substance Dependence ◽  
Co Morbidity

Standard EMDR Protocol for Alcohol and Substance Dependence Comorbid With Posttraumatic Stress Disorder: Four Cases With 12-Month Follow-Up

2016 ◽  
Vol 10 (1) ◽  
pp. 33-46 ◽  
Author(s):  
Claire Kullack ◽  
Jonathan Laugharne
Keyword(s):  
Posttraumatic Stress Disorder ◽  
Substance Use ◽  
Alcohol Dependence ◽  
Posttraumatic Stress ◽  
Substance Use Disorders ◽  
Substance Dependence ◽  
Stress Disorder ◽  
Case Series ◽  
Post Traumatic Stress

This report begins with a summary of the literature regarding the theoretical models behind the comorbid relationship between posttraumatic stress disorder and substance use disorders and the various modified addiction protocols formulated to assist in treating these disorders. This case series outlines the effect that the standard eye movement desensitization and reprocessing (EMDR) protocol had on alcohol and substance dependence for 4 patients who attended our Post Traumatic Stress Clinic in Fremantle, Western Australia, primarily for treatment for posttraumatic stress disorder. Patients were assessed for substance use disorders using the Mini International Neuropsychiatric Interview Plus prior to, immediately after, and 12 months after completing EMDR therapy. Results indicate that the standard EMDR protocol was successful in reducing alcohol and substance use. Prior to treatment, 3 patients met criteria for alcohol dependence and 1 met criteria for substance dependence. At 12-month follow-up, 3 out of 4 clients did not meet the diagnostic criteria for current alcohol dependence or current substance dependence. The implications of these findings are discussed with reference to theories of comorbid posttraumatic stress disorder and substance use disorder and the modified EMDR protocols developed for patients with substance dependence.

scholarly journals Predictors of Illicit Substance Dependence Among Individuals With Alcohol Dependence

2009 ◽  
Vol 70 (2) ◽  
pp. 269-278 ◽  
Author(s):  
Nicole D. Sintov ◽  
Kenneth S. Kendler ◽  
Dermot Walsh ◽  
Diana G. Patterson ◽  
Carol A. Prescott
Keyword(s):  
Alcohol Dependence ◽  
Substance Dependence ◽  
Illicit Substance

A Co-Morbidity of Alcohol Dependence with Other Psychiatric Disorders in Young Adult Mexican Americans

2007 ◽  
Vol 26 (4) ◽  
pp. 31-40 ◽  
Author(s):  
David A. Gilder ◽  
Philip Lau ◽  
Abigail Gross ◽  
Cindy L. Ehlers
Keyword(s):  
Young Adult ◽  
Alcohol Dependence ◽  
Psychiatric Disorders ◽  
Mexican Americans ◽  
Co Morbidity

Association Study of OPRM1 Gene in a Sample of Schizophrenia Patients With Alcohol Dependence or Abuse

2019 ◽  
Vol 10 (4) ◽  
pp. 30-34
Author(s):  
Marie N.S. Gendy ◽  
Clement Zai ◽  
Bernard Le Foll ◽  
James L. Kennedy
Keyword(s):  
Alcohol Dependence ◽  
Association Study ◽  
Oprm1 Gene

Co-morbidity and familial aggregation of alcoholism and anxiety disorders

1998 ◽  
Vol 28 (4) ◽  
pp. 773-788 ◽  
Author(s):  
K. R. MERIKANGAS ◽  
D. E. STEVENS ◽  
B. FENTON ◽  
M. STOLAR ◽  
S. O'MALLEY ◽  
...  
Keyword(s):  
Anxiety Disorders ◽  
Alcohol Dependence ◽  
Social Phobia ◽  
Familial Aggregation ◽  
Familial Risk ◽  
Family History Information ◽  
Self Medication ◽  
Co Morbidity ◽  
History Information ◽  
Familial Risk Factors

Background. This study examined the patterns of familial aggregation and co-morbidity of alcoholism and anxiety disorders in the relatives of 165 probands selected for alcoholism and/or anxiety disorders compared to those of 61 unaffected controls.Methods. Probands were either selected from treatment settings or at random from the community. DSM-III-R diagnoses were obtained for all probands and their 1053 first-degree relatives, based on direct interview or family history information.Results. The findings indicate that: (1) alcoholism was associated with anxiety disorders in the relatives, particularly among females; (2) both alcoholism and anxiety disorders were highly familial; (3) the familial aggregation of alcoholism was attributable to alcohol dependence rather than to alcohol abuse, particularly among male relatives; and (4) the pattern of co-aggregation of alcohol dependence and anxiety disorders in families differed according to the subtype of anxiety disorder; there was evidence of a partly shared diathesis underlying panic and alcoholism, whereas social phobia and alcoholism tended to aggregate independently.Conclusions. The finding that the onset of social phobia tended to precede that of alcoholism, when taken together with the independence of familial aggregation of social phobia and alcoholism support a self-medication hypothesis as the explanation for the co-occurrence of social phobia and alcoholism. In contrast, the lack of a systematic pattern in the order of onset of panic and alcoholism among subjects with both disorders as well as evidence for shared underlying familial risk factors suggests that co-morbidity between panic disorder and alcoholism is not a consequence of self-medication of panic symptoms. The results of this study emphasize the importance of examining co-morbid disorders and subtypes thereof in identifying sources of heterogeneity in the pathogenesis of alcoholism.

scholarly journals Genome-wide association study of body mass index in subjects with alcohol dependence

2015 ◽  
Vol 22 (2) ◽  
pp. 535-549 ◽  
Author(s):  
Renato Polimanti ◽  
Huiping Zhang ◽  
Andrew H. Smith ◽  
Hongyu Zhao ◽  
Lindsay A. Farrer ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Alcohol Dependence ◽  
Association Study ◽  
Body Mass ◽  
Genome Wide Association Study ◽  
Genome Wide Association ◽  
Genome Wide

Association Study of theSLC6A3VNTR (DAT) andDRD2/ANKK1Taq1A Polymorphisms with Alcohol Dependence in a Population from Northeastern Brazil

2015 ◽  
Vol 39 (2) ◽  
pp. 205-211 ◽  
Author(s):  
Any Carolina C. G. Vasconcelos ◽  
Edmilson de Souza R. Neto ◽  
Giovanny R. Pinto ◽  
France Keiko N. Yoshioka ◽  
Fábio José N. Motta ◽  
...  
Keyword(s):  
Alcohol Dependence ◽  
Association Study ◽  
Northeastern Brazil

Posttraumatic disorders in patients with alcohol dependence: Prevalence and integrated treatment

2011 ◽  
Vol 26 (S2) ◽  
pp. 2115-2115
Author(s):  
I. Schäfer
Keyword(s):  
Substance Abuse ◽  
Alcohol Dependence ◽  
Dual Diagnosis ◽  
Substance Dependence ◽  
Stress Disorder ◽  
Integrated Treatment ◽  
German Version ◽  
Seeking Safety ◽  
The Past ◽  
Promising Treatment

Over the past decade, the importance of co-occurring posttraumatic disorders in patients with substance dependence has become increasingly apparent. In clinical populations of addicted patients, about 25 to 50 percent receive a lifetime diagnosis of Posttraumatic Stress Disorder (PTSD). The talk will give an overview of the prevalence of PTSD and other trauma related disorders in European samples of patients with substance dependence. Moreover, data on experiences with the German version of an integrated treatment program for PTSD and substance abuse („Seeking Safety”, Najavits 2002) in N = 38 female outpatients with alcohol dependence will be reported. The results suggest that participants’ satisfaction with the content of the treatment, its structure and the session handouts was high. “Seeking Safety” therefore seems to be a promising treatment also for European patients with the dual diagnosis of PTSD and substance abuse.

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