scholarly journals Ceramides affect alcohol consumption and depressive‐like and anxiety‐like behavior in a brain region‐ and ceramide species‐specific way in male mice

2019 ◽  
Vol 25 (6) ◽  
Author(s):  
Iulia Zoicas ◽  
Sabine E. Huber ◽  
Liubov S. Kalinichenko ◽  
Erich Gulbins ◽  
Christian P. Müller ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Brain Region ◽  
Male Mice ◽  
Species Specific

scholarly journals Chronic Repeated Predatory Stress Induces Resistance to Quinine Adulteration of Ethanol in Male Mice

2019 ◽  
Author(s):  
Gladys A. Shaw ◽  
Maria Alexis M. Bent ◽  
Kimaya R. Council ◽  
A. Christian Pais ◽  
Ananda Amstadter ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Open Field ◽  
Traumatic Event ◽  
Drinking Behavior ◽  
Specific Pattern ◽  
Male Mice ◽  
Female Mice ◽  
Drinking Response ◽  
Field Mice ◽  
The Impact

AbstractBackgroundTrauma related psychiatric disorders, such as posttraumatic stress disorder (PTSD), and alcohol use disorder (AUD) are highly comorbid illnesses that separately present an opposing, sex-specific pattern, with increased prevalence of PTSD in females and increased prevalence of AUD diagnoses in males. Likewise, PTSD is a risk factor in the development of AUD, with conflicting data on the impact of sex in the comorbid development of both disorders. Because the likelihood of experiencing more than one traumatic event is high, we aim to utilize chronic repeated predatory stress (CRPS) to query the extent to which sex interacts with CRPS to influence alcohol consumption, or cessation of consumption.MethodsMale (n=16) and female (n=15) C57BL/6J mice underwent CRPS or daily handling for two weeks during adolescence (P35-P49) and two weeks during adulthood (P65-P79). Following the conclusion of two rounds of repeated stress, behavior was assessed in the open field. Mice subsequently underwent a two-bottle choice intermittent ethanol access (IEA) assessment (P90-131) with the options of 20% ethanol or water. After establishing drinking behavior, increasing concentrations of quinine were added to the ethanol to assess the drinking response to adulteration of the alcohol.ResultsCRPS increased fecal corticosterone concentrations and anxiety-like behaviors in the open field in both male and female mice as compared to control mice that had not been exposed to CRPS. Consistent with previous reports, we observed a sex difference in alcohol consumption such that females consumed more ethanol per gram of body mass than males. In addition, CRPS reduced alcohol aversion in male mice such that higher concentrations of quinine were necessary to reduce alcohol intake as compared to control mice. CRPS did not alter alcohol-related behaviors in female mice.ConclusionCollectively, we demonstrate that repeated CRPS can induce anxiety-like behavior in both sexes but selectively influences the response to ethanol adulteration in males.

scholarly journals A Traditional Chinese Medicine Plant Extract Prevents Alcohol-Induced Osteopenia

2021 ◽  
Vol 12 ◽  
Author(s):  
Dongyang Qian ◽  
Hui Zhou ◽  
Pan Fan ◽  
Tao Yu ◽  
Anish Patel ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Alcohol Consumption ◽  
Traditional Chinese Medicine ◽  
Bone Diseases ◽  
Syzygium Aromaticum ◽  
Herbal Extracts ◽  
Male Mice ◽  
Middle Aged ◽  
Excessive Alcohol Consumption ◽  
Excessive Alcohol

Traditional Chinese medicine (TCM) has been practiced in the treatment of bone diseases and alcoholism. Chronic excessive alcohol use results in alcohol-induced bone diseases, including osteopenia and osteoporosis, which increases fracture risk, deficient bone repair, and osteonecrosis. This preclinical study investigated the therapeutic effects of TCM herbal extracts in animal models of chronic excessive alcohol consumption-induced osteopenia. TCM herbal extracts (Jing extracts) were prepared from nine Chinese herbal medicines, a combinative herbal formula for antifatigue and immune regulation, including Astragalus, Cistanche deserticola, Dioscorea polystachya, Lycium barbarum, Epimedium, Cinnamomum cassia, Syzygium aromaticum, Angelica sinensis, and Curculigo orchioides. In this study, Balb/c male mice were orally administrated alcohol (3.2 g/kg/day) with/without TCM herbal extracts (0.125 g/kg, 0.25 g/kg, or 0.5 g/kg) by gavage. Our results showed that after 50 days of oral administration, TCM herbal extracts prevented alcohol-induced osteopenia demonstrated by μ-CT bone morphological analysis in young adults and middle-aged/old Balb/c male mice. Biochemical analysis demonstrated that chronic alcohol consumption inhibits bone formation and has a neutral impact on bone resorption, suggesting that TCM herbal extracts (Jing extracts) mitigate the alcohol-induced abnormal bone metabolism in middle-aged/old male mice. Protocatechuic acid, a natural phenolic acid in Jing extracts, mitigates in vivo alcohol-induced decline of alkaline phosphatase (ALP) gene expression in the bone marrow of Balb/c male mice and in vitro ALP activity in pre-osteoblast MC3T3-E1 cells. Our study suggests that TCM herbal extracts prevent chronic excessive alcohol consumption-induced osteopenia in male mice, implying that traditional medicinal plants have the therapeutic potential of preventing alcohol-induced bone diseases.

scholarly journals A cortical-brainstem circuit predicts and governs compulsive alcohol drinking

Science ◽  
2019 ◽  
Vol 366 (6468) ◽  
pp. 1008-1012 ◽  
Author(s):  
Cody A. Siciliano ◽  
Habiba Noamany ◽  
Chia-Jung Chang ◽  
Alex R. Brown ◽  
Xinhong Chen ◽  
...  
Keyword(s):  
Individual Differences ◽  
Alcohol Consumption ◽  
Binge Drinking ◽  
Neural Activity ◽  
Alcohol Drinking ◽  
Cortical Neurons ◽  
Activity Patterns ◽  
Mechanistic Explanation ◽  
Male Mice ◽  
Latent Traits

What individual differences in neural activity predict the future escalation of alcohol drinking from casual to compulsive? The neurobiological mechanisms that gate the transition from moderate to compulsive drinking remain poorly understood. We longitudinally tracked the development of compulsive drinking across a binge-drinking experience in male mice. Binge drinking unmasked individual differences, revealing latent traits in alcohol consumption and compulsive drinking despite equal prior exposure to alcohol. Distinct neural activity signatures of cortical neurons projecting to the brainstem before binge drinking predicted the ultimate emergence of compulsivity. Mimicry of activity patterns that predicted drinking phenotypes was sufficient to bidirectionally modulate drinking. Our results provide a mechanistic explanation for individual variance in vulnerability to compulsive alcohol drinking.

Increased alcohol consumption in relaxin-3 deficient male mice

2016 ◽  
Vol 612 ◽  
pp. 155-160 ◽  
Author(s):  
Takahira Shirahase ◽  
Miku Aoki ◽  
Ryuji Watanabe ◽  
Yoshihisa Watanabe ◽  
Masaki Tanaka
Keyword(s):  
Alcohol Consumption ◽  
Male Mice

scholarly journals Transgenic overexpression of CTRP3 does not prevent alcohol induced hepatic steatosis in female mice

PLoS ONE ◽  
2022 ◽  
Vol 17 (1) ◽  
pp. e0258557
Author(s):  
Kristy L. Thomas ◽  
Callie L. Root ◽  
Jonathan M. Peterson
Keyword(s):  
Liver Disease ◽  
Alcohol Consumption ◽  
Transgenic Mice ◽  
Cytokine Production ◽  
Specific Effect ◽  
Related Protein ◽  
Male Mice ◽  
Female Mice ◽  
Hepatic Lipid Accumulation ◽  
Overall Mortality

Alcoholic liver disease (ALD) is one of the leading causes of morbidity and mortality from hepatic complications. C1q/TNF-related protein 3 (CTRP3) is an adiponectin paralog and, in male mice, increased levels of circulating CTRP3 prevents ALD. Therefore, the purpose of this study was to replicate the observed hepatoprotective effect of elevated circulating CTRP3 levels in female mice. Twelve-week-old female wildtype and CTRP3 overexpressing transgenic mice were fed the Lieber-DeCarli alcohol-containing liquid diet (5% vol/vol) for 6 weeks. Unlike the previous study with male mice, CTRP3 overexpression provided no attenuation to alcohol-induced hepatic lipid accumulation, cytokine production, or overall mortality. In conclusion, there appears to be a clear sex-specific effect of CTRP3 in response to alcohol consumption that needs to be explored further.

scholarly journals Inhibition of the Inflammasome Signaling Cascade Reduces Alcohol Consumption in Female But Not Male Mice

2020 ◽  
Vol 44 (2) ◽  
pp. 567-578 ◽  
Author(s):  
Patrick P. Lowe ◽  
Yeonhee Cho ◽  
David Tornai ◽  
Sahin Coban ◽  
Donna Catalano ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Signaling Cascade ◽  
Male Mice

scholarly journals Alcohol Consumption Promotes Diethylnitrosamine-Induced Hepatocarcinogenesis in Male Mice through Activation of the Wnt/β-Catenin Signaling Pathway

2014 ◽  
Vol 7 (7) ◽  
pp. 675-685 ◽  
Author(s):  
Kelly E. Mercer ◽  
Leah Hennings ◽  
Neha Sharma ◽  
Keith Lai ◽  
Mario A. Cleves ◽  
...  
Keyword(s):  
Alcohol Consumption ◽  
Signaling Pathway ◽  
Male Mice

scholarly journals Alcohol Consumption and Its Effect on Testicular Structure and on Sperm Count and Motility in Parent Mice and Their Offspring

2013 ◽  
Vol 12 (1) ◽  
Author(s):  
Cinaria T. Albadri
Keyword(s):  
Alcohol Consumption ◽  
Sperm Count ◽  
Male Offspring ◽  
Seminiferous Tubules ◽  
Control Group ◽  
Ethanol Treatment ◽  
Male Mice ◽  
Female Mice ◽  
Group 2 ◽  
Group 1

Introduction: The goal of the present study was to examine the effect of alcohol consumption on sperm count and motility and the morphological changes in the seminiferous tubules of parent mice and their offspring. Methods: Animals were divided into two groups, Group 1 (alcohol group) of twelve male and twelve female mice, were given a daily dose of (3 g/kg body weight as 25%, v/v) ethanol by gastric gavage for four and eight weeks. Group 2 (control group) also of twelve male and twelve female mice; received normal access of food and water. After four weeks of treatment, the males and females in each group were allowed to mate, and ethanol treatment continued for up to another four weeks. Twelve male offspring from group 1 and twelve male offspring from group 2 were selected randomly and allowed to become mature. Male parent mice were killed at the 4th and 8th weeks of treatment, and their male offsprings were killed when they reached maturity age. Results: Physiological examination of the sperm solution showed that there was a significant decrease in sperm count and motility after 4 and 8 weeks of ethanol treatment in parent male mice, but this decrease was not significant in their adult offspring. Furthermore, histological investigations indicated testicular lesions in the parent male mice and their adult male offspring. Conclusion: Alcohol abuse has deleterious effects on the testes structure and on the sperm count and motility of the epididymal spermatozoa of both parent mice and their offspring.

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