Preventive effect ofPueraria mirificaon testosterone-induced prostatic hyperplasia in Sprague Dawley rats

Andrologia ◽  
2015 ◽  
Vol 47 (10) ◽  
pp. 1153-1159 ◽  
Author(s):  
S. S. Masrudin ◽  
J. Mohamad
Keyword(s):  
Prostatic Hyperplasia ◽  
Preventive Effect ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Preventive effect of berberine against DMBA-induced breast cancer in female Sprague Dawley rats

2017 ◽  
Vol 92 ◽  
pp. 207-214 ◽  
Author(s):  
Kalyani Chowdary Karnam ◽  
Maheswara Ellutla ◽  
Lakshmi Narendra Bodduluru ◽  
Eshvendar Reddy Kasala ◽  
Shravan Kumar Uppulapu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Preventive Effect ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Preventive effect of Elateriospermum tapos seed extract against obese Sprague Dawley rats

2019 ◽  
Vol 20 (1) ◽  
pp. 107-113
Author(s):  
Kokila Vani Perumal ◽  
Nor Liyana Ja’afar ◽  
Santhra Segaran Balan ◽  
Azrina Zainal Abidin ◽  
Daryl J. Arapoc ◽  
...  
Keyword(s):  
Seed Extract ◽  
Preventive Effect ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

Effects of coconut oil on testosterone-induced prostatic hyperplasia in Sprague-Dawley rats

2007 ◽  
Vol 59 (7) ◽  
pp. 995-999 ◽  
Author(s):  
María de Lourdes Arruzazabala ◽  
Vivian Molina ◽  
Rosa Más ◽  
Daisy Carbajal ◽  
David Marrero ◽  
...  
Keyword(s):  
Coconut Oil ◽  
Prostatic Hyperplasia ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Effect of sorghum ethyl-acetate extract on benign prostatic hyperplasia induced by testosterone in Sprague–Dawley rats

2018 ◽  
Vol 82 (12) ◽  
pp. 2101-2108 ◽  
Author(s):  
Jae-Myun Ryu ◽  
Gwi Yeong Jang ◽  
Dongsun Park ◽  
Koan Sik Woo ◽  
Tae Myoung Kim ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Prostatic Hyperplasia ◽  
Sprague Dawley ◽  
Sprague Dawley Rats

scholarly journals Preventive Effect of Crocin on Osteoporosis in an Ovariectomized Rat Model

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Peng-Chong Cao ◽  
Wen-Xing Xiao ◽  
Ya-Bo Yan ◽  
Xiong Zhao ◽  
Shuai Liu ◽  
...  
Keyword(s):  
Elderly Women ◽  
Osteoporosis Treatment ◽  
Therapeutic Effects ◽  
Preventive Effect ◽  
Sprague Dawley ◽  
Trabecular Microarchitecture ◽  
Sprague Dawley Rats ◽  
Oxidative Stress Status ◽  
Turnover Markers ◽  
Higher Doses

The purpose of this study was to investigate the therapeutic effects of crocin on ovariectomy-induced osteoporosis in rats. Female Sprague-Dawley rats were randomly assigned to a sham-operated group (sham) and five ovariectomy (OVX) subgroups, that is, OVX with vehicle (OVX), OVX with 17β-estradiol (E2, 25 μg/kg/day), and OVX with graded crocin doses (5, 10, or 20 mg/kg/day). Daily oral administration ofE2or crocin started 4 weeks after OVX and lasted for 16 weeks. Our results showed that crocin dose-dependently inhibited the BMD reduction of L4 vertebrae and femurs caused by OVX and prevented the deterioration of trabecular microarchitecture, which were accompanied by a significant decrease in skeletal remodeling as evidenced by the lower levels of bone turnover markers. Furthermore, crocin reversed the oxidative stress status in both serum and bone tissue. The present study indicates that the administration of crocin at higher doses over a 16-week period can prevent OVX-induced osteoporosis in rats without hyperplastic effects on the uterus, which may, at least partially, be attributed to crocin’s antioxidative property. In brief, crocin is a natural alternative for postmenopausal osteoporosis treatment in elderly women.

scholarly journals The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Hongcai Cai ◽  
Guowei Zhang ◽  
Zechen Yan ◽  
Xuejun Shang
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Caspase 3 ◽  
Positive Control ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Sprague Dawley ◽  
Elderly Men ◽  
Sprague Dawley Rats ◽  
Increased Activity ◽  
Anti Inflammation

Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis.

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