Triptolide reduces prostate size and androgen level on testosterone-induced benign prostatic hyperplasia in Sprague Dawley rats

2017 ◽  
Vol 15 (5) ◽  
pp. 341-346 ◽  
Author(s):  
Yu-Rong WANG ◽  
Yuan XU ◽  
Zhen-Zhou JIANG ◽  
Lu-Yong ZHANG ◽  
Tao WANG
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Sprague Dawley ◽  
Androgen Level ◽  
Sprague Dawley Rats ◽  
Prostate Size

scholarly journals The Effect of Xialiqi Capsule on Testosterone-Induced Benign Prostatic Hyperplasia in Rats

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Hongcai Cai ◽  
Guowei Zhang ◽  
Zechen Yan ◽  
Xuejun Shang
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Caspase 3 ◽  
Positive Control ◽  
Prostatic Hyperplasia ◽  
Control Group ◽  
Sprague Dawley ◽  
Elderly Men ◽  
Sprague Dawley Rats ◽  
Increased Activity ◽  
Anti Inflammation

Benign prostatic hyperplasia (BPH) is common among elderly men, of which inflammation, oxidative stress, proliferative, and apoptotic changes play important roles. Xialiqi (XLQ) capsule, a traditional Chinese herbal formula, is used as a potential drug in treating BPH. This study aims to evaluate the therapeutic effect of XLQ capsule on testosterone propionate- (TP-) induced BPH in rats. Fifty male Sprague-Dawley rats were randomly divided into 5 groups: sham control, BPH model, high and low dose of XLQ, and finasteride as a positive control group. All groups were treated with appropriate drugs/normal saline for 28 consecutive days. Prostate weights were recorded; histopathological changes and content of IL-8, TNF-α, DHT, SOD, MDA, caspase-3, and PCNA of the prostate were determined. Animals with BPH demonstrated significantly increased prostate weights and prostate index, higher levels of IL-8, TNF-α, DHT, MDA, and PCNA, but lower activity of SOD and reduced expression of caspase-3. After treatment with XLQ, significant reductions of prostate weights, prostate index, IL-8, TNF-α, DHT, MDA, and PCNA, increased activity of SOD, and higher level of caspase-3 were shown. The present study indicates that XLQ can effectively prevent the development of TP-induced BPH model through mechanisms of anti-inflammation, antioxidation, antiproliferation, and proapoptosis.

scholarly journals Metabolomic Analysis of Morus Cultivar Root Extracts and Their Ameliorative Effect on Testosterone-Induced Prostate Enlargement in Sprague-Dawley Rats

2020 ◽  
Vol 21 (4) ◽  
pp. 1435 ◽  
Author(s):  
Young-Jin Choi ◽  
Jae In Lee ◽  
Meiqi Fan ◽  
Yujiao Tang ◽  
Eun-Jung Yoon ◽  
...  
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostate Specific Antigen ◽  
Specific Antigen ◽  
Mapk Signaling ◽  
Prostatic Hyperplasia ◽  
Mitogen Activated Protein Kinase ◽  
Sprague Dawley ◽  
Sprague Dawley Rats ◽  
Related Proteins ◽  
The Relationship

We investigated the metabolite changes of Morus roots (MRs) according to different cultivar families (Simheung, Daesim, Cheong-il, Sangchon, Daeseong, Suhong, Suwon, and Igsu) using ultra-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UPLC–QTOF-MS) to understand the relationship between different cultivars and metabolite changes. Data were analyzed by partial least squares discriminant analysis (PLS-DA), and samples were successfully separated in PLS-DA scores. Eight metabolites in the electrospray ionization (ESI)-positive mode and 16 metabolites in the ESI-negative mode contributed to the separation in PLS-DA. Our data suggest that comparative analysis of MR metabolites according to different cultivars is useful to better understand the relationship between the different cultivars and metabolite changes. Furthermore, we analyzed the MRs for their ability to improve benign prostatic hyperplasia (BPH). LNCaP cells were used to evaluate the prostate-specific antigen (PSA) inhibitory activity of MRs, and, amongst them, the extract with the highest activity was selected. Igsu demonstrated the highest inhibition effect of prostate-specific antigen (PSA) expression among the MR cultivars. Igsu was also evaluated by administration in a testosterone-induced benign prostatic hyperplasia model in Sprague-Dawley rats. Igsu was shown to ameliorate BPH as evidenced by the prostate index, expression of androgen receptor (AR) signaling-related protein, growth factors, cell proliferation-related proteins, apoptosis-related proteins, mitogen-activated protein kinase (MAPK) signaling proteins, and histological analysis. Hence, this study strongly suggests that Igsu may have a beneficial effect of on BPH.

scholarly journals The relationship between glucose homeostasis status and prostate size in aging Chinese males with benign prostatic hyperplasia

2020 ◽  
Vol 38 (11) ◽  
pp. 2923-2931
Author(s):  
Y. Wu ◽  
Y. Ding ◽  
Q. F. Cao ◽  
S. B. Qian ◽  
C. Wang ◽  
...  
Keyword(s):  
Growth Rate ◽  
Benign Prostatic Hyperplasia ◽  
Glucose Homeostasis ◽  
Transrectal Ultrasound ◽  
Transitional Zone ◽  
Prostatic Hyperplasia ◽  
Significant Difference ◽  
Prostate Size ◽  
Prostate Growth ◽  
The Relationship

Abstract Purpose Increasing evidence shows that many metabolic factors are involved in the progression of benign prostatic hyperplasia (BPH). We aimed to assess the relationship between the status of glucose homeostasis and prostate size in aging Chinese males undergoing transurethral resection of the prostate (TURP) for BPH. Methods A total of 1006 medical records of BPH patients undergoing TURP were reviewed. Prostate size was measured by transrectal ultrasound. Annual total prostate (TP) and transitional zone (TZ) growth rates were calculated. According to the American Diabetes Association criteria, the patients were categorized as normoglycemic, prediabetic, or diabetic. Levels of glucose homeostasis and other variables were considered independent variables in an effort to evaluate any potential correlations using non-adjusted and multivariate-adjusted regression models. Results A total of 659 individuals were included in the study. BPH patients < 70 years old and ≥ 70 years old in the normoglycemic group had a stable prostate growth rate. The change in prostate size in those younger than 70 years, however, was faster in the prediabetic and diabetic group. Further analysis revealed that abnormal glucose homeostasis was positively correlated with prostate size. In those younger than 70 years, compared with the normal glucose group, the adjusted odds ratio (OR) for TP and TZ enlargement in the prediabetic group was 2.27 (95%CI 1.29–4.00) and 3.19 (95%CI 1.78–5.72), respectively, and the adjusted ORs were 4.74 (95%CI 2.18–10.30) and 6.16 (95%CI 2.70–14.06), respectively, for men with diabetes. However there was no significant difference among men aged ≥ 70 years. Conclusions Among patients undergoing TURP, the prostate volume and growth rate were affected by different status of glucose homeostasis. Hyperglycemia may play an important role in prostate growth.

Over expression of PI3K-AkT reduces apoptosis and increases prostate size in benign prostatic hyperplasia

2018 ◽  
pp. 1-7 ◽  
Author(s):  
Karli Sreenivasulu ◽  
Hanumanthappa Nandeesha ◽  
Lalgudi Narayanan Dorairajan ◽  
Rajesh Nachiappa Ganesh
Keyword(s):  
Benign Prostatic Hyperplasia ◽  
Prostatic Hyperplasia ◽  
Over Expression ◽  
Prostate Size
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