Protective effects of Lepidium draba L . leaves extract on testis histopathology, oxidative stress indicators, serum reproductive hormones and inflammatory signalling in oxymetholone‐treated rat

Andrologia ◽  
2021 ◽  
Author(s):  
Yanbo Wang ◽  
Liang Bai ◽  
Huiting Li ◽  
Wenjun Yang ◽  
Min Li
Keyword(s):  
Oxidative Stress ◽  
Reproductive Hormones ◽  
Protective Effects ◽  
Stress Indicators ◽  
Lepidium Draba ◽  
Inflammatory Signalling ◽  
Oxidative Stress Indicators

NEOPTERIN VERSUS OXIDATIVE STRESS INDICATORS AMONG EGYPTIAN WORKERS IN MARBLE INDUSTRY

2015 ◽  
Vol 39 (1) ◽  
pp. 67-83
Author(s):  
Gaballah MF ◽  
Manawil M ◽  
El-Sherif GH
Keyword(s):  
Oxidative Stress ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
Marble Industry

scholarly journals Fluctuation of oxidative stress indicators in Salix nigra seeds during priming

2012 ◽  
Vol 63 (10) ◽  
pp. 3631-3642 ◽  
Author(s):  
G. Roqueiro ◽  
S. Maldonado ◽  
M. d. C. Rios ◽  
H. Maroder
Keyword(s):  
Oxidative Stress ◽  
Salix Nigra ◽  
Stress Indicators ◽  
Oxidative Stress Indicators

scholarly journals XBP1-Mediated BiP/GRP78 Upregulation Copes with Oxidative Stress in Mosquito Cells during Dengue 2 Virus Infection

2017 ◽  
Vol 2017 ◽  
pp. 1-14 ◽  
Author(s):  
Tien-Huang Chen ◽  
Yi-Hsuan Chiang ◽  
Jiun-Nan Hou ◽  
Chih-Chieh Cheng ◽  
Eny Sofiyatun ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Target Gene ◽  
Cytosolic Calcium ◽  
Cellular Damage ◽  
Factor X ◽  
Stress Indicators ◽  
Mosquito Cells ◽  
Tropical Areas ◽  
Oxidative Stress Indicators ◽  
Denv2 Infection

Dengue viruses (DENVs) cause dengue fever which is an important mosquito-borne disease in tropical areas. Generally, DENV does not cause cellular damage in mosquito cells. However, alterations in cytosolic calcium ions ([Ca2+]cyt) and the mitochondrial membrane potential (MMP), as well as accumulated reactive oxygen species (ROS), including superoxide anions (O2∙-) and hydrogen peroxide (H2O2), can be detected in C6/36 cells with DENV2 infection. Evident upregulation of BiP/GRP78 also appeared at 24 h postinfection in DENV2-infected C6/36 cells. As expression of BiP/GRP78 mRNA was reduced when the transcription factor X-box-binding protein-1 (XBP1) was knocked down in C6/36 cells, it demonstrated that BiP/GRP78 is the target gene regulated by the XBP1 signal pathway. We further demonstrated that the expression and splicing activity of XBP1 were upregulated in parallel with DENV2 infection in C6/36 cells. In C6/36 cells with BiP/GRP78 overexpression, oxidative stress indicators including [Ca2+]cyt, MMP,O2∙-, and H2O2were all pushed back to normal. Taken together, DENV2 activates XBP1 at earlier stage of infection, followed by upregulating BiP/GRP78 in mosquito cells. This regulatory pathway contributes a cascade in relation to oxidative stress alleviation. The finding provides insights into elucidating how mosquitoes can healthily serve as a vector of arboviruses in nature.

Effect of exercise therapy on lipid profile and oxidative stress indicators in patients with type 2 diabetes

2009 ◽  
Vol 33 (3) ◽  
pp. 236
Author(s):  
L. Gordon ◽  
E. Morrison ◽  
D. McGrowder ◽  
D. Goorwood ◽  
Y. Terry Pena Fraser
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Lipid Profile ◽  
Exercise Therapy ◽  
Stress Indicators ◽  
Oxidative Stress Indicators ◽  
And Oxidative Stress

scholarly journals Sophocarpine Attenuates LPS-Induced Liver Injury and Improves Survival of Mice through Suppressing Oxidative Stress, Inflammation, and Apoptosis

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Zhengyu Jiang ◽  
Yan Meng ◽  
Lulong Bo ◽  
Changli Wang ◽  
Jinjun Bian ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Injury ◽  
Great Part ◽  
Protective Role ◽  
Stress Indicators ◽  
Oxidative Reaction ◽  
Hepatic Expression ◽  
Jnk Cascade ◽  
Oxidative Stress Indicators

Septic liver injury/failure that is mainly characterized by oxidative stress, inflammation, and apoptosis led to a great part of terminal liver pathology with limited effective intervention. Here, we used a lipopolysaccharide (LPS) stimulation model to simulate the septic liver injury and investigated the effect of sophocarpine on LPS-stimulated mice with endotoxemia. We found that sophocarpine increases the survival rate of mice and attenuates the LPS-induced liver injury, which is indicated by pathology and serum liver enzymes. Further research found that sophocarpine ameliorated hepatic oxidative stress indicators (H2O2, O2∙−, and NO) and enhanced the expression of antioxidant molecules such as superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH). In addition, sophocarpine also attenuated regional and systematic inflammation and further reduced apoptosis of hepatocytes. Mechanistic evidence was also investigated in the present study as sophocarpine inhibited hepatic expression of the CYP2E/Nrf2 pathway during oxidative stress, inactivated p38/JNK cascade and NF-κB pathway, and, meanwhile, suppressed PI3K/AKT signaling that reduced apoptosis. Conclusively, the present study unveiled the protective role of sophocarpine in LPS-stimulated oxidative reaction, inflammation, and apoptosis by suppressing the CYP2E/Nrf2/ROS as well as PI3K/AKT pathways, suggesting its promising role in attenuating inflammation and liver injury of septic endotoxemia.

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