Outcomes of diverting loop ileostomy reversal in the elderly: a case–control study

Abstract Background The national immunization program (NIP) of annual influenza vaccination to the elderly population (≥65 years of age) in the Republic of Korea (ROK) has been implemented since 1987. Recently, the 23-valent pneumococcal polysaccharide vaccine (PPV23) through the NIP has been provided to the elderly population in the ROK since May 2013. The aim of this study was to assess PPV23 and influenza vaccine (IV) effectiveness in preventing pneumococcal pneumonia (PP) among elderly patients ≥65 years of age. Methods A case–control study using a hospital-based cohort was conducted. Cases of PP including bacteremic PP and nonbacteremic PP were collected from 14 hospitals in the pneumococcal diseases surveillance program from March 2013 to October 2015. Controls matched by age and sex in the same hospital were selected. Demographic, clinical information, and vaccination histories were collected. Previous immunization was categorized into “vaccinated” if a patient had received vaccines as follows: PPV23 (4 weeks to 5 years) and IV (2 weeks to 6 months) prior to the diagnosis of PP for case patients and prior to the hospital admission for control patients. Adjusted odds ratio (OR) was calculated, controlling for underlying medical conditions. Vaccine effectiveness was defined as (1 – OR) × 100. Results During the study period, a total of 661 cases (104 bacteremic PP cases and 557 nonbacteremic PP cases) and 661 controls were enrolled for analyses. For overall patients ≥65 years of age, there was no significant vaccine effectiveness against PP. For young elderly patients with 65–74 years, IV alone (1.2%, [95% confidence interval (CI) −95.3% to 50.0%]) and PPV23 alone (21.9%, [95% CI −39.0% to 56.1%]) were not effective. However, significant vaccine effectiveness of PPV23 plus IV against PP was noted (54.4%, [95% CI 6.9–77.7%], P = 0.031). For older elderly patients ≥75 years of age, no significant vaccine effectiveness was observed. Conclusion Our study indicates that PPV23 plus IV may be effective in preventing PP among young elderly patients with 65–74 years, suggesting additive benefits of influenza plus PPV23 vaccination. Further studies are required to confirm the persistent additive protective effectiveness. Disclosures All authors: No reported disclosures.

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Neuroleptic drug exposure and treatment of parkinsonism in the elderly: A case-control study

The American Journal of Medicine ◽

10.1016/s0002-9343(99)80104-1 ◽

1995 ◽

Vol 99 (1) ◽

pp. 48-54 ◽

Cited By ~ 38

Author(s):

Jerry Avorn ◽

Rhonda L. Bohn ◽

Helen Mogun ◽

Jerry H. Gurwitz ◽

Mark Monane ◽

...

Keyword(s):

Drug Exposure ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Neuroleptic Drug ◽

Control Study

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A Case-Control Study on Risk Factors affected Peripherals Neuropathic complication in Elderly with Type 2 Diabetes Mellitus

Research Journal of Pharmacy and Technology ◽

10.52711/0974-360x.2021.00700 ◽

2021 ◽

pp. 4040-4046

Author(s):

Made Krisna Adi Jaya ◽

Dewa Ayu Swastini ◽

Baiq Leny Nopitasari ◽

Putu Rika Veryanti

Keyword(s):

Diabetes Mellitus ◽

Risk Factors ◽

Type 2 Diabetes ◽

Type 2 Diabetes Mellitus ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Smoking History ◽

Control Study

Background: Diabetic Peripheral Neuropathy (DPN) is a microvascular complication that commonly occurs in people with diabetes mellitus. Geriatrics with type 2 diabetes mellitus is one of the populations most vulnerable to this complication. An epidemiological study states that geriatrics has a 32% greater risk of developing this complication compared to other age groups. There have not been many studies conducted to evaluate the risk factors that influence this DPN complication, so it needs to be done an individual evaluation for the elderly population. Objective: This study aims to explore the risk factors that influence the incidence of DPN in elderly patients with type 2 diabetes mellitus. Methods: A case-control study design was carried out on 70 geriatrics with type 2 diabetes mellitus. The outcome determined was the incidence of DPN to track the cause of DPN exposure retrospectively. Influential risk factors are determined by the Odds Ratio (OR) with a 95% confidence interval (CI). All statistical analyzes were two-tailed, and p-values <0.05 were considered as statistically significant. Results: Seven factors influence the incidence of DPN in the elderly consisting of smoking history (OR=13.1), uncontrolled lipid profile (OR=5.1), non-neuroprotector users (OR=5.6), uncontrolled blood glucose (OR=42.7), history of heart disease (OR=9.0), uncontrolled blood pressure (OR=4.3), and BMI above normal (OR=5.1). Conclusion: Strong recommendation for medical personnel to focus attention on seven significant risk factors affected complications of DPN to reduce its progression or prevent upcoming complications.

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Malnutrition Concerning Geriatric Depression and Associated Risk Factors: A Community-based Case-control Study in Rural Elderly of Bangladesh

10.21203/rs.3.rs-127639/v1 ◽

2020 ◽

Author(s):

Md Ziaul Islam ◽

Tasnim Disu ◽

Shatmin Farjana ◽

Mohammad Rahman

Keyword(s):

Risk Factors ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Rural Elderly ◽

Geriatric Depression ◽

Elderly Individuals ◽

Significant Difference ◽

Associated Risk Factors ◽

Control Study

Abstract Background: Malnutrition and depression are highly prevalent in the elderly and can lead to disparaging outcomes. Analytical studies on malnutrition concerning geriatric depression (GD) are very scarce in Bangladesh, although the size of the elderly population is increasing fast in the country. The current study aimed to assess the association between malnutrition and depression and associated risk factors in the rural elderly.Methods: A case-control study was conducted in 600 elderly residents (aged ≥60 years) of three rural communities of Bangladesh from January to October 2019. Three hundred depressed elderly people were enrolled as cases and 300 non-depressed elderly individuals were included as community controls by matching the age and living area of the cases. We used a semi-structured questionnaire based on the Geriatric Depression Scale-15 and the Bangla version of Mini-Nutritional Assessment-Short Form to collect data through face-to-face interviews. Measures included baseline and personal characteristics, malnutrition, GD, and associated risk factors. A binary logistic regression model was fitted to identify variables associated with the risk of GD.Results: The study found no significant difference in gender (male Vs. female) between cases (44.0% Vs. 56.0%) and controls (46.0% Vs. 54.0%). The study revealed that malnutrition was significantly (p<0.01) higher in cases (56.0%) than in controls (18.0%). The malnourished elderly had around three times AOR=3.155; 95% CI: 1.53-6.49, p=0.002) more (risk of having depression than the controls. The unemployed elderly (AOR=4.964; 95% CI: 2.361-10.440; p=0.0001) and the elderly of the lower and middle class (AOR=3.654; 95% CI: 2.266-7.767; p=0.001) were more likely to experience depression. The elderly having a poor diet were more likely to experience depression (AOR=3.384; 95% CI: 1.764-6.703; p=0.0001). The single elderly (AOR=2.368; 95% CI: 1.762-6.524; p=0.001) and the elderly tobacco users (AOR=2.332; 95% CI: 1.663-5.623; p=0.003) were more likely to experience depression.Conclusions: A significant association between malnutrition and depression is evident in the rural elderly individuals of Bangladesh. It will be a prolific initiative if policymakers merge malnutrition and the risk factors associated with geriatric depression in the provision of universal health care for better health and well-being of the rural elderly populations.

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Relations among Chronic Medical Conditions, Medications, and Automobile Crashes in the Elderly: A Population-based Case-Control Study

American Journal of Epidemiology ◽

10.1093/aje/152.5.424 ◽

2000 ◽

Vol 152 (5) ◽

pp. 424-431 ◽

Cited By ~ 192

Author(s):

G. McGwin

Keyword(s):

Case Control Study ◽

The Elderly ◽

Population Based ◽

Case Control ◽

Chronic Medical Conditions ◽

Medical Conditions ◽

Automobile Crashes ◽

Control Study

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Is the adjuvanted influenza vaccine more effective than the trivalent inactivated vaccine in the elderly population? Results of a case-control study

European Journal of Public Health ◽

10.1093/eurpub/cku165.055 ◽

2014 ◽

Vol 24 (suppl_2) ◽

Author(s):

V Colamesta ◽

B Unim ◽

A Spadea ◽

A Meneghini ◽

AM D’Amici ◽

...

Keyword(s):

Influenza Vaccine ◽

Elderly Population ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Inactivated Vaccine ◽

Control Study

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A case-control study of accidental hypothermia in the elderly in relation to social support and social circumstances

Journal of Public Health ◽

10.1093/oxfordjournals.pubmed.a043921 ◽

1987 ◽

Keyword(s):

Social Support ◽

Case Control Study ◽

The Elderly ◽

Case Control ◽

Accidental Hypothermia ◽

Control Study

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Efficacy and safety of vedolizumab in elderly patients with inflammatory bowel disease: a matched case–control study

Gastroenterology Report ◽

10.1093/gastro/goz041 ◽

2019 ◽

Vol 8 (4) ◽

pp. 306-311 ◽

Cited By ~ 1

Author(s):

Preeti Shashi ◽

Dharmesh Gopalakrishnan ◽

Malav P Parikh ◽

Bo Shen ◽

Gursimran Kochhar

Keyword(s):

Inflammatory Bowel Disease ◽

Elderly Patients ◽

Case Control Study ◽

The Elderly ◽

Mucosal Healing ◽

Case Control ◽

Elderly Group ◽

Efficacy And Safety ◽

Inflammatory Bowel ◽

Control Study

Abstract Background Vedolizumab was demonstrated to be safe and effective in adults with moderately to severely active inflammatory bowel disease (IBD) in clinical trials. However, there are limited data regarding its efficacy and safety in elderly patients. Methods This was a case–control study comparing the efficacy (measured by rates of mucosal healing and need for IBD surgery) and safety of vedolizumab in IBD among patients ≥65 years of age (the elderly group) vs those <65 years (the control group). The two groups were matched individually on a 1:4 ratio based on gender and type of IBD. Conditional logistic regression was used for stratified analysis to calculate odds ratios and confidence intervals. Results We included 25 IBD patients in the elderly group and 100 matched patients in the comparison group. Eighty patients had Crohn’s disease and 45 had ulcerative colitis. At baseline, the groups were comparable with regard to duration of IBD, prior anti-TNF therapy, and prior IBD surgery. The rate of mucosal healing on follow-up endoscopy was comparable between the elderly and control groups (50% vs 53%, P = 0.507). Although more patients in the elderly group required IBD-related surgery while on vedolizumab, the difference did not reach statistical significance (40% vs 19%, P = 0.282). Rates of vedolizumab-related adverse effects—rash, arthralgia, infections, infusion reactions, and dyspnea—were comparable between the two groups (all P > 0.05). Conclusions In a real-world setting, vedolizumab was demonstrated to have an efficacy and safety profile among elderly IBD patients that were comparable to younger controls.

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