scholarly journals Uptake of fetal aneuploidy screening after the introduction of the non‐invasive prenatal test: A national population‐based register study

2021 ◽  
Author(s):  
Karuna R. M. Meij ◽  
Maurike Groot‐van Mooren ◽  
Ellen W. S. Carbo ◽  
Mijntje J. Pieters ◽  
Wendy Rodenburg ◽  
...  
Keyword(s):  
Population Based ◽  
Register Study ◽  
Aneuploidy Screening ◽  
National Population ◽  
Non Invasive ◽  
Fetal Aneuploidy ◽  
Prenatal Test

scholarly journals Routinization of prenatal screening with the non-invasive prenatal test: pregnant women’s perspectives

2021 ◽  
Author(s):  
Karuna R. M. van der Meij ◽  
Annabel Njio ◽  
Linda Martin ◽  
Janneke T. Gitsels-van der Wal ◽  
Mireille N. Bekker ◽  
...  
Keyword(s):  
Down Syndrome ◽  
Pregnant Women ◽  
Prenatal Screening ◽  
Screening Program ◽  
Informed Choice ◽  
Aneuploidy Screening ◽  
Non Invasive ◽  
Fetal Aneuploidy ◽  
Societal Pressure ◽  
Prenatal Test

AbstractDue to the favorable test characteristics of the non-invasive prenatal test (NIPT) in the screening of fetal aneuploidy, there has been a strong and growing demand for implementation. In the Netherlands, NIPT is offered within a governmentally supported screening program as a first-tier screening test for all pregnant women (TRIDENT-2 study). However, concerns have been raised that the test’s favorable characteristics might lead to uncritical use, also referred to as routinization. This study addresses women’s perspectives on prenatal screening with NIPT by evaluating three aspects related to routinization: informed choice, freedom to choose and (personal and societal) perspectives on Down syndrome. Nationwide, a questionnaire was completed by 751 pregnant women after receiving counseling for prenatal screening. Of the respondents, the majority (75.5%) made an informed choice for prenatal screening as measured by the multidimensional measure of informed choice (MMIC). Education level and religious affiliation were significant predictors of informed choice. The main reason to accept screening was “seeking reassurance” (25.5%), and the main reason to decline was “every child is welcome” (30.6%). The majority of respondents (87.7%) did not perceive societal pressure to test. Differences between test-acceptors and test-decliners in personal and societal perspectives on Down syndrome were found. Our study revealed high rates of informed decision-making and perceived freedom to choose regarding fetal aneuploidy screening, suggesting that there is little reason for concern about routinization of NIPT based on the perspectives of Dutch pregnant women. Our findings highlight the importance of responsible implementation of NIPT within a national screening program.

scholarly journals OP01.03: A clinical comparative study between conventional fetal aneuploidy screening and contingent screening using the non-invasive prenatal testing

2018 ◽  
Vol 52 ◽  
pp. 66-67
Author(s):  
A. Bernabeu ◽  
M. Sanchez ◽  
M. Aviles ◽  
J. Ramis ◽  
I. Calero ◽  
...  
Keyword(s):  
Comparative Study ◽  
Prenatal Testing ◽  
Aneuploidy Screening ◽  
Non Invasive ◽  
Fetal Aneuploidy

scholarly journals Fetal aneuploidy screening by non-invasive prenatal testing of maternal plasma DNA sequencing with “false negative” result due to confined placental mosaicism

Medicine ◽  
2020 ◽  
Vol 99 (29) ◽  
pp. e20848
Author(s):  
Xiaozhou Li ◽  
Duan Ju ◽  
Yunfang Shi ◽  
Yan Li ◽  
Haiwei Dong ◽  
...  
Keyword(s):  
Dna Sequencing ◽  
False Negative ◽  
Prenatal Testing ◽  
Maternal Plasma ◽  
False Negative Result ◽  
Plasma Dna ◽  
Aneuploidy Screening ◽  
Non Invasive ◽  
Fetal Aneuploidy ◽  
Placental Mosaicism

Geographical Differences in Likelihood of Home Death Among Palliative Cancer Patients: A National Population-based Register Study

2020 ◽  
Vol 40 (7) ◽  
pp. 3897-3903
Author(s):  
JONAS NILSSON ◽  
BERTIL AXELSSON ◽  
GEORG HOLGERSSON ◽  
TOBIAS CARLSSON ◽  
MICHAEL BERGQVIST ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Population Based ◽  
Register Study ◽  
Home Death ◽  
Geographical Differences ◽  
National Population

Contingent non-invasive prenatal testing: an opportunity to improve non-genetic aspects of fetal aneuploidy screening

2015 ◽  
Vol 35 (13) ◽  
pp. 1347-1352 ◽  
Author(s):  
Wilfried Gyselaers ◽  
Frank Hulstaert ◽  
Mattias Neyt
Keyword(s):  
Prenatal Testing ◽  
Aneuploidy Screening ◽  
Non Invasive ◽  
Fetal Aneuploidy

scholarly journals Does non‐invasive prenatal testing (NIPT) affect the livebirth prevalence of Down syndrome in the Netherlands? A population‐based register study

2021 ◽  
Author(s):  
M D Mooren ◽  
G Graaf ◽  
M E Weijerman ◽  
M J V Hoffer ◽  
J Knijnenburg ◽  
...  
Keyword(s):  
Down Syndrome ◽  
The Netherlands ◽  
Prenatal Testing ◽  
Population Based ◽  
Register Study ◽  
Non Invasive

scholarly journals Association between pyrethroid exposure and cardiovascular disease: A national population-based cross-sectional study in the US

2021 ◽  
Vol 153 ◽  
pp. 106545
Author(s):  
Qingping Xue ◽  
An Pan ◽  
Ying Wen ◽  
Yichao Huang ◽  
Da Chen ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Population Based ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
National Population ◽  
The Us
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