The potential benefits of Lactobacillus farraginis and Enterococcus durans , isolated from kefir, as probiotic candidates on innate immune responses, expression of some immune genes, and resistance to Lactococcosis disease in juvenile rainbow trout

2021 ◽  
Author(s):  
Mohsen Ali ◽  
Siyavash Soltanian ◽  
Ali Taheri Mirghaed ◽  
Mostafa akhlaghi ◽  
Seyed Hossein Hoseinifar ◽  
...  
Keyword(s):  
Rainbow Trout ◽  
Immune Responses ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Enterococcus Durans ◽  
Immune Genes ◽  
Juvenile Rainbow Trout ◽  
Potential Benefits

The effects of dietary supplementation of mistletoe (Viscum album) extract on the growth performance, antioxidant, and innate, immune responses of rainbow trout (Oncorhynchus mykiss)

Aquaculture ◽  
2021 ◽  
Vol 536 ◽  
pp. 736385
Author(s):  
Morteza Yousefi ◽  
Mehdi Naderi Farsani ◽  
Hamed Ghafarifarsani ◽  
Seyed Hossein Hoseinifar ◽  
Hien Van Doan
Keyword(s):  
Rainbow Trout ◽  
Immune Responses ◽  
Oncorhynchus Mykiss ◽  
Growth Performance ◽  
Dietary Supplementation ◽  
Viscum Album ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Rainbow Trout Oncorhynchus Mykiss

scholarly journals The neuropeptide receptor NMUR-1 regulates the specificity of C. elegans innate immunity against pathogen infection

2021 ◽  
Author(s):  
Phillip Wibisono ◽  
Shawndra Wibisono ◽  
Jan Watteyne ◽  
Chia-Hui Chen ◽  
Durai Sellegounder ◽  
...  
Keyword(s):  
Innate Immunity ◽  
Immune System ◽  
Immune Responses ◽  
Adaptive Immune System ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Immune Genes ◽  
C Elegans ◽  
Adaptive Immune ◽  
Functional Assays

A key question in current immunology is how the innate immune system generates high levels of specificity. Like most invertebrates, Caenorhabditis elegans does not have an adaptive immune system and relies solely on innate immunity to defend itself against pathogen attacks, yet it can still differentiate different pathogens and launch distinct innate immune responses. Here, we have found that functional loss of NMUR-1, a neuronal GPCR homologous to mammalian receptors for the neuropeptide neuromedin U, has diverse effects on C. elegans survival against various bacterial pathogens. Transcriptomic analyses and functional assays revealed that NMUR-1 modulates C. elegans transcription activity by regulating the expression of transcription factors, which, in turn, controls the expression of distinct immune genes in response to different pathogens. Our study has uncovered a molecular basis for the specificity of C. elegans innate immunity that could provide mechanistic insights into understanding the specificity of vertebrate innate immunity.

scholarly journals Vaccination Route Determines the Kinetics and Magnitude of Nasal Innate Immune Responses in Rainbow Trout (Oncorhynchus mykiss)

Biology ◽  
2020 ◽  
Vol 9 (10) ◽  
pp. 319
Author(s):  
Fen Dong ◽  
Luca Tacchi ◽  
Zhen Xu ◽  
Scott E. LaPatra ◽  
Irene Salinas
Keyword(s):  
Rainbow Trout ◽  
Immune Responses ◽  
Survival Rates ◽  
Innate Immune ◽  
Immune Gene ◽  
Innate Immune Responses ◽  
Farmed Fish ◽  
Nasal Vaccination ◽  
Highly Effective ◽  
Response Expression

Many pathogens infect animal hosts via the nasal route. Thus, understanding how vaccination stimulates early nasal immune responses is critical for animal and human health. Vaccination is the most effective method to prevent disease outbreaks in farmed fish. Nasal vaccination induces strong innate and adaptive immune responses in rainbow trout and was shown to be highly effective against infectious hematopoietic necrosis (IHN). However, direct comparisons between intranasal, injection and immersion vaccination routes have not been conducted in any fish species. Moreover, whether injection or immersion routes induce nasal innate immune responses is unknown. The goal of this study is to compare the effects of three different vaccine delivery routes, including intranasal (IN), intramuscular (i.m.) injection and immersion (imm) routes on the trout nasal innate immune response. Expression analyses of 13 immune-related genes in trout nasopharynx-associated lymphoid tissue (NALT), detected significant changes in immune expression in all genes analyzed in response to the three vaccination routes. However, nasal vaccination induced the strongest and fastest changes in innate immune gene expression compared to the other two routes. Challenge experiments 7 days post-vaccination (dpv) show the highest survival rates in the IN- and imm-vaccinated groups. However, survival rates in the imm group were significantly lower than the IN- and i.m.-vaccinated groups 28 dpv. Our results confirm that nasal vaccination of rainbow trout with live attenuated IHNV is highly effective and that the protection conferred by immersion vaccination is transient. These results also demonstrate for the first time that immersion vaccines stimulate NALT immune responses in salmonids.

scholarly journals Effect of vitamin C on innate immune responses of rainbow trout ( Oncorhynchus mykiss ) leukocytes

2017 ◽  
Vol 67 ◽  
pp. 179-188 ◽  
Author(s):  
Esther Leal ◽  
Carlos Zarza ◽  
Carolina Tafalla
Keyword(s):  
Rainbow Trout ◽  
Vitamin C ◽  
Immune Responses ◽  
Oncorhynchus Mykiss ◽  
Innate Immune ◽  
Innate Immune Responses ◽  
Rainbow Trout Oncorhynchus Mykiss
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