scholarly journals Mannose and phosphomannose isomerase regulate energy metabolism under glucose starvation in leukemia

2021 ◽  
Author(s):  
Yusuke Saito ◽  
Mariko Kinoshita ◽  
Ai Yamada ◽  
Sayaka Kawano ◽  
Hong‐Shan Liu ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Glucose Starvation ◽  
Phosphomannose Isomerase ◽  
Regulate Energy Metabolism

scholarly journals MDM2 ubiquitin-ligase down-regulate energy metabolism of cancer cells

2019 ◽  
Vol 35 (3) ◽  
pp. 233-233
Author(s):  
O. Shuvalov ◽  
A. Petukhov ◽  
O. Fedorova ◽  
A. Daks ◽  
E. Baidyuk ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Regulate Energy Metabolism

Neurotransmitters Regulate Energy Metabolism in Astrocytes: Implications for the Metabolic Trafficking between Neural Cells

1993 ◽  
Vol 15 (3-5) ◽  
pp. 306-312 ◽  
Author(s):  
Pierre J. Magistretti ◽  
Olivier Sorg ◽  
Naichen Yu ◽  
Jean-Luc Martin ◽  
Luc Pellerin
Keyword(s):  
Energy Metabolism ◽  
Neural Cells ◽  
Regulate Energy Metabolism

Adaptive regulation of glucose transport, glycolysis and respiration for cell proliferation

2015 ◽  
Vol 6 (5-6) ◽  
pp. 423-430 ◽  
Author(s):  
Yusuke Toyoda ◽  
Shigeaki Saitoh
Keyword(s):  
Cell Proliferation ◽  
Energy Metabolism ◽  
Glucose Transport ◽  
Neurodegenerative Disorders ◽  
Human Diseases ◽  
Molecular Regulation ◽  
Adaptive Regulation ◽  
Metabolism Regulation ◽  
Recent Advances ◽  
Regulate Energy Metabolism

AbstractThe cell must utilise nutrients to generate energy as a means of sustaining its life. As the environment is not necessarily abundant in nutrients and oxygen, the cell must be able to regulate energy metabolism to adapt to changes in extracellular and intracellular conditions. Recently, several key regulators of energy metabolism have been reported. This review describes the recent advances in molecular regulation of energy metabolism, focusing mainly on glycolysis and its shunt pathways. Human diseases, such as cancer and neurodegenerative disorders, are also discussed in relation to failure of energy metabolism regulation.

scholarly journals Energy metabolism regulates clathrin adaptors at the trans-Golgi network and endosomes

2013 ◽  
Vol 24 (6) ◽  
pp. 832-847 ◽  
Author(s):  
Quyen L. Aoh ◽  
Chao-wei Hung ◽  
Mara C. Duncan
Keyword(s):  
Energy Metabolism ◽  
Intracellular Signaling ◽  
Phosphatidyl Inositol ◽  
Glucose Starvation ◽  
Yeast Saccharomyces Cerevisiae ◽  
Permeabilized Cells ◽  
Trans Golgi Network ◽  
Golgi Network ◽  
Energy Dependent ◽  
Adp Ribosylation Factor

Glucose is a master regulator of cell behavior in the yeast Saccharomyces cerevisiae. It acts as both a metabolic substrate and a potent regulator of intracellular signaling cascades. Glucose starvation induces the transient delocalization and then partial relocalization of clathrin adaptors at the trans-Golgi network and endosomes. Although these localization responses are known to depend on the protein kinase A (PKA) signaling pathway, the molecular mechanism of this regulation is unknown. Here we demonstrate that PKA and the AMP-regulated kinase regulate adaptor localization through changes in energy metabolism. We show that genetic and chemical manipulation of intracellular ATP levels cause corresponding changes in adaptor localization. In permeabilized cells, exogenous ATP is sufficient to induce adaptor localization. Furthermore, we reveal distinct energy-dependent steps in adaptor localization: a step that requires the ADP-ribosylation factor ARF, an ATP-dependent step that requires the phosphatidyl-inositol-4 kinase Pik1, and third ATP-dependent step for which we provide evidence but for which the mechanism is unknown. We propose that these energy-dependent mechanisms precisely synchronize membrane traffic with overall proliferation rates and contribute a crucial aspect of energy conservation during acute glucose starvation.

scholarly journals SustainedO-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism

2017 ◽  
Vol 292 (36) ◽  
pp. 14940-14962 ◽  
Author(s):  
Ee Phie Tan ◽  
Steven R. McGreal ◽  
Stefan Graw ◽  
Robert Tessman ◽  
Scott J. Koppel ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Mitochondrial Function ◽  
Regulate Energy Metabolism

Bile acid metabolism and circadian rhythms

2020 ◽  
Vol 319 (5) ◽  
pp. G549-G563
Author(s):  
Yunxia Yang ◽  
Jianfa Zhang
Keyword(s):  
Bile Acid ◽  
Energy Metabolism ◽  
Circadian Rhythms ◽  
Acid Metabolism ◽  
Metabolic Diseases ◽  
Nutrient Absorption ◽  
Bile Acid Metabolism ◽  
Future Perspectives ◽  
Circadian Oscillators ◽  
Regulate Energy Metabolism

Circadian rhythms are biological systems that synchronize cellular circadian oscillators and regulate nutrient absorption and utilization. Bile acids are important modulators that facilitate nutrient absorption and regulate energy metabolism. Bile acid metabolism and circadian rhythms are related to metabolic diseases, and their intersections have not been summarized clearly up to now. This review summarizes the molecular association between circadian rhythms and bile acid metabolism and points out future perspectives and potential therapeutic targets in metabolic diseases.

scholarly journals The Pim protein kinases regulate energy metabolism and cell growth

2010 ◽  
Vol 108 (2) ◽  
pp. 528-533 ◽  
Author(s):  
Z. Beharry ◽  
S. Mahajan ◽  
M. Zemskova ◽  
Y.-W. Lin ◽  
B. G. Tholanikunnel ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cell Growth ◽  
Protein Kinases ◽  
Regulate Energy Metabolism
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