Natural compounds regulate energy metabolism by the modulating the activity of lipid-sensing nuclear receptors

2012 ◽  
Vol 57 (1) ◽  
pp. 20-33 ◽  
Author(s):  
Tsuyoshi Goto ◽  
Young-Il Kim ◽  
Nobuyuki Takahashi ◽  
Teruo Kawada
Keyword(s):  
Energy Metabolism ◽  
Nuclear Receptors ◽  
Natural Compounds ◽  
Lipid Sensing ◽  
Regulate Energy Metabolism

scholarly journals Identification of a Liver-Specific Uridine Phosphorylase that Is Regulated by Multiple Lipid-Sensing Nuclear Receptors

2004 ◽  
Vol 18 (4) ◽  
pp. 851-862 ◽  
Author(s):  
Yuan Zhang ◽  
Joyce J. Repa ◽  
Yusuke Inoue ◽  
Graham P. Hayhurst ◽  
Frank J. Gonzalez ◽  
...  
Keyword(s):  
Nuclear Receptors ◽  
Uridine Phosphorylase ◽  
Lipid Sensing

scholarly journals MDM2 ubiquitin-ligase down-regulate energy metabolism of cancer cells

2019 ◽  
Vol 35 (3) ◽  
pp. 233-233
Author(s):  
O. Shuvalov ◽  
A. Petukhov ◽  
O. Fedorova ◽  
A. Daks ◽  
E. Baidyuk ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Cancer Cells ◽  
Ubiquitin Ligase ◽  
Regulate Energy Metabolism

Neurotransmitters Regulate Energy Metabolism in Astrocytes: Implications for the Metabolic Trafficking between Neural Cells

1993 ◽  
Vol 15 (3-5) ◽  
pp. 306-312 ◽  
Author(s):  
Pierre J. Magistretti ◽  
Olivier Sorg ◽  
Naichen Yu ◽  
Jean-Luc Martin ◽  
Luc Pellerin
Keyword(s):  
Energy Metabolism ◽  
Neural Cells ◽  
Regulate Energy Metabolism

Adaptive regulation of glucose transport, glycolysis and respiration for cell proliferation

2015 ◽  
Vol 6 (5-6) ◽  
pp. 423-430 ◽  
Author(s):  
Yusuke Toyoda ◽  
Shigeaki Saitoh
Keyword(s):  
Cell Proliferation ◽  
Energy Metabolism ◽  
Glucose Transport ◽  
Neurodegenerative Disorders ◽  
Human Diseases ◽  
Molecular Regulation ◽  
Adaptive Regulation ◽  
Metabolism Regulation ◽  
Recent Advances ◽  
Regulate Energy Metabolism

AbstractThe cell must utilise nutrients to generate energy as a means of sustaining its life. As the environment is not necessarily abundant in nutrients and oxygen, the cell must be able to regulate energy metabolism to adapt to changes in extracellular and intracellular conditions. Recently, several key regulators of energy metabolism have been reported. This review describes the recent advances in molecular regulation of energy metabolism, focusing mainly on glycolysis and its shunt pathways. Human diseases, such as cancer and neurodegenerative disorders, are also discussed in relation to failure of energy metabolism regulation.

scholarly journals PPARs in Calorie Restricted and Genetically Long-Lived Mice

PPAR Research ◽  
2007 ◽  
Vol 2007 ◽  
pp. 1-7 ◽  
Author(s):  
Michal M. Masternak ◽  
Andrzej Bartke
Keyword(s):  
Transcription Factors ◽  
Energy Metabolism ◽  
Nuclear Receptors ◽  
Calorie Restriction ◽  
Insulin Action ◽  
Peroxisome Proliferator ◽  
Physiological Functions ◽  
Multiple Organs ◽  
Longevity Genes ◽  
Peroxisome Proliferator Activated Receptors

Peroxisome proliferator-activated receptors (PPARs) are members of the nuclear receptors superfamily. The three subtypes, PPARα, PPARγ, and PPARβ/δ, are expressed in multiple organs. These transcription factors regulate different physiological functions such as energy metabolism (including lipid and carbohydrate metabolism), insulin action, and immunity and inflammation, and apparently also act as important mediators of longevity and aging. Calorie restriction (CR) is the most effective intervention known to delay aging and increase lifespan. Calorie restriction affects the same physiological functions as PPARs. This review summarizes recent findings on the effects of CR and aging on the expression of PPARγ,α, andβ/δin mice and discusses possible involvement of PPARs in mediating the effects of murine longevity genes. The levels of PPARs change with age and CR appears to prevent these alterations which make “PPARs-CR-AGING” dependence of considerable interest.

scholarly journals Mycobacterium tuberculosis Modulates Macrophage Lipid-Sensing Nuclear Receptors PPARγ and TR4 for Survival

2012 ◽  
Vol 188 (11) ◽  
pp. 5593-5603 ◽  
Author(s):  
Sahil Mahajan ◽  
H. Kitdorlang Dkhar ◽  
Vemika Chandra ◽  
Sandeep Dave ◽  
Ravikanth Nanduri ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
Nuclear Receptors ◽  
Lipid Sensing

scholarly journals SustainedO-GlcNAcylation reprograms mitochondrial function to regulate energy metabolism

2017 ◽  
Vol 292 (36) ◽  
pp. 14940-14962 ◽  
Author(s):  
Ee Phie Tan ◽  
Steven R. McGreal ◽  
Stefan Graw ◽  
Robert Tessman ◽  
Scott J. Koppel ◽  
...  
Keyword(s):  
Energy Metabolism ◽  
Mitochondrial Function ◽  
Regulate Energy Metabolism
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