Outdoor pollen‐related changes in lung function and markers of airway inflammation: A systematic review and meta‐analysis

2021 ◽  
Vol 51 (5) ◽  
pp. 636-653 ◽  
Author(s):  
Nur Sabrina Idrose ◽  
E. Haydn Walters ◽  
Jingwen Zhang ◽  
Don Vicendese ◽  
Ed J. Newbigin ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Airway Inflammation ◽  
Meta Analysis

Effect of aerobic exercise training on asthma in adults: a systematic review and meta-analysis

2020 ◽  
Vol 56 (1) ◽  
pp. 2000146 ◽  
Author(s):  
Erik Soeren Halvard Hansen ◽  
Anders Pitzner-Fabricius ◽  
Louise Lindhardt Toennesen ◽  
Hanne Kruuse Rasmusen ◽  
Morten Hostrup ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Exercise Training ◽  
Aerobic Exercise ◽  
Airway Inflammation ◽  
Asthma Control ◽  
Meta Analysis ◽  
Risk Of Bias ◽  
Aerobic Exercise Training ◽  
Controlled Trials

ObjectiveTo evaluate the effect of aerobic exercise training on asthma control, lung function and airway inflammation in adults with asthma.DesignSystematic review and meta-analysis.MethodsRandomised controlled trials investigating the effect of ≥8 weeks of aerobic exercise training on outcomes for asthma control, lung function and airway inflammation in adults with asthma were eligible for study. MEDLINE, Embase, CINAHL, PEDro and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched up to April 3, 2019. Risk of bias was assessed using the Cochrane Risk of Bias Tool.ResultsWe included 11 studies with a total of 543 adults with asthma. Participants' mean (range) age was 36.5 (22–54) years; 74.8% of participants were female and the mean (range) body mass index was 27.6 (23.2–38.1) kg·m−2. Interventions had a median (range) duration of 12 (8–12) weeks and included walking, jogging, spinning, treadmill running and other unspecified exercise training programmes. Exercise training improved asthma control with a standard mean difference (SMD) of −0.48 (−0.81–−0.16). Lung function slightly increased with an SMD of −0.36 (−0.72–0.00) in favour of exercise training. Exercise training had no apparent effect on markers of airway inflammation (SMD −0.03 (−0.41–0.36)).ConclusionsIn adults with asthma, aerobic exercise training has potential to improve asthma control and lung function, but not airway inflammation.

scholarly journals Effects of exercise training on physical and psychosocial health in children with chronic respiratory disease: a systematic review and meta-analysis

2018 ◽  
Vol 4 (1) ◽  
pp. e000409 ◽  
Author(s):  
Barbara Joschtel ◽  
Sjaan R Gomersall ◽  
Sean Tweedy ◽  
Helen Petsky ◽  
Anne B Chang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Exercise Training ◽  
Respiratory Disease ◽  
Effect Size ◽  
Meta Analysis ◽  
Chronic Respiratory Disease ◽  
Cardiovascular Fitness ◽  
Standard Mean Difference ◽  
Children With Asthma

IntroductionChronic disease in children is increasing, including the prevalence of chronic respiratory diseases such as asthma, cystic fibrosis (CF), bronchiectasis and bronchopulmonary dysplasia (BPD). The aim of this systematic review and meta-analysis was to evaluate the effects of exercise training on health outcomes in children with chronic respiratory disease.MethodFive databases were searched for randomised controlled trials investigating the effects of exercise training on children with chronic respiratory disease. Following the PRISMA guidelines, eligible studies were identified and data were extracted. A meta-analysis was conducted for the outcomes cardiovascular fitness, lung function and quality of life (QoL).ResultsThe initial search returned 3688 papers. Twenty-seven (17 in children with asthma, 10 in children with CF) were included in the systematic review and 24 of these were included in the meta-analysis. No studies were identified in children with bronchiectasis or BPD. Included papers had a total of 1009 participants aged 8–20 years. In addition to cardiovascular fitness, lung function and QoL, studies also assessed pulmonary function, respiratory muscle strength, muscular strength and inflammation. Meta-analysis showed a large significant effect size in favour of exercise for cardiovascular fitness (peak VO2) (standard mean difference (SMD)=1.16, 95%  CI 0.61 to 1.70) and QoL (SMD=1.27, 95% CI 0.72 to 1.82) as well as a small, non-significant effect size for lung function (FEV1) (SMD=0.02, 95% CI -0.38 to 0.42).ConclusionExercise training significantly improves cardiovascular fitness and QoL in children with asthma and CF. Further research is needed, particularly in children with bronchiectasis and BPD.

scholarly journals Association between active tobacco use during pregnancy and infant respiratory health: a systematic review and meta-analysis

BMJ Open ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. e037819
Author(s):  
Ediane De Queiroz Andrade ◽  
Carla Rebeca Da Silva Sena ◽  
Adam Collison ◽  
Vanessa E Murphy ◽  
Gillian Sandra Gould ◽  
...  
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Tobacco Use ◽  
Smokeless Tobacco ◽  
Respiratory Health ◽  
Data Extraction ◽  
Meta Analysis ◽  
Maximum Flow ◽  
Eligibility Criteria ◽  
Residual Capacity

ObjectiveTo evaluate what is known about active tobacco use during pregnancy and the association with infant respiratory health.DesignSystematic review and meta-analysis using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines.Data sourcesMEDLINE, EMBASE, Cochrane, CINAHL, and Maternity and Infant Care were searched thoroughly until June 2020.Eligibility criteria for selecting studiesWe included case–control and cohort studies estimating the association between active tobacco use during pregnancy and infant respiratory health (wheezing and apnoea) and lung function parameters in the first 12 months of life.Data extraction and synthesisExtraction and risk of bias assessment were conducted by two independent reviewers. The odds ratio, relative risk and mean differences were pooled with a 95% CI using the generic inverse variance method. Heterogeneity was assessed and expressed by percentage using I2.ResultsWe identified 4423 abstracts, and 21 publications met the eligibility criteria. Pooled OR showed an increase in wheezing episodes in infants born to mothers who were active tobacco users during pregnancy (OR 1.50, 95% CI 1.27 to 1.77, p<0.01). Mixed results were found on lung function parameters, and a meta-analysis including two studies with comparable methodology showed a trend towards reduced maximum flow rate at functional residual capacity of −34.59 mL/s (95% CI −72.81 to 3.63, p=0.08) in 1-month-old infants born to women who smoked during pregnancy. A higher risk of apnoea was described for infants born to mothers who used smokeless tobacco during pregnancy, while the results in infants born to women who actively smoked tobacco during pregnancy were non-conclusive.ConclusionInfants born to mothers who actively smoked during pregnancy are at higher odds of having wheeze and may have lower lung function. Smokeless tobacco use in pregnancy may increase the risk of apnoea in infancy.PROSPERO registration numberCRD42018083936.

Pesticide exposure and lung function: a systematic review and meta-analysis

2019 ◽  
Author(s):  
Jate Ratanachina ◽  
Sara De Matteis ◽  
Paul Cullinan ◽  
Peter Burney
Keyword(s):  
Systematic Review ◽  
Lung Function ◽  
Pesticide Exposure ◽  
Meta Analysis

Birth Weight and Lung Function in Adulthood: A Systematic Review and Meta-analysis

2017 ◽  
Vol 14 (6) ◽  
pp. 994-1004 ◽  
Author(s):  
Neil J. Saad ◽  
Jaymini Patel ◽  
Peter Burney ◽  
Cosetta Minelli
Keyword(s):  
Systematic Review ◽  
Birth Weight ◽  
Lung Function ◽  
Meta Analysis

scholarly journals 552The lung function and airway inflammation markers associated with short-term pollen exposure- A systematic review

2021 ◽  
Vol 50 (Supplement_1) ◽  
Author(s):  
N. Sabrina Idrose ◽  
Caroline Lodge ◽  
Jennifer Koplin ◽  
Don Vicendese ◽  
Jo Douglass ◽  
...  
Keyword(s):  
Lung Function ◽  
Airway Inflammation ◽  
Meta Analysis ◽  
Qualitative Synthesis ◽  
Short Term ◽  
Cross Sectional ◽  
Random Effects Models ◽  
Newcastle Ottawa Scale ◽  
Pollen Exposure

Abstract Background Experimental challenge studies have shown that pollen can affect the lungs and airways. Here, we systematically reviewed community-based studies investigating outdoor pollen exposure, lung function and/or airway inflammation. Methods Four online databases were searched. The search strategy included terms relating to both exposure and outcomes. Inclusion criteria were studies published in English that were representative of the community. We only considered cross-sectional or short-term longitudinal studies which investigated pollen exposure by levels or season. Study quality assessment was performed using the Newcastle-Ottawa scale. Meta-analysis was conducted using random-effects models. Results We included 27 of 6,551 studies identified from the search. Qualitative synthesis indicated associations between pollen exposure and predominantly type-2 inflammation in both the upper and lower airways, but little evidence for lung function changes. People with ever asthma and/or seasonal allergic rhinitis (SAR) were at higher risk of such airway inflammation. Meta-analysis confirmed a positive relationship between pollen season and eosinophilic airway inflammation in people with ever SAR but the results between studies were highly variable. Heterogeneity was reduced after further subgrouping by age and the forest plots indicated that eosinophilic airway inflammation to outdoor pollen exposure increased with age. Conclusion Among people with ever asthma and ever SAR, exposure to increased ambient pollen triggers type-2 airway inflammation rather than a non-specific or innate inflammation. Key messages This review indicates pollen exposure influences predominantly type-2 airway inflammation, but little evidence on lung function.

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