Do Inhaled Corticosteroids Influence Lung Function Decline in Patients with Stable COPD: A Systematic Review and Meta-Analysis of Four Major Longitudinal Studies.

Author(s):  
T Debowski ◽  
AM Fal ◽  
J Malolepszy
2012 ◽  
Vol 42 (5) ◽  
pp. 1186-1193 ◽  
Author(s):  
Joanna Szram ◽  
Susie J. Schofield ◽  
Martin P. Cosgrove ◽  
Paul Cullinan

2021 ◽  
Vol 24 ◽  
Author(s):  
Alexandra Bălăceanu ◽  
Delia Vîrgă ◽  
Laurentiu Maricuțoiu

Abstract Based on the Job Demands-Resources theory, this meta‐analysis investigates the role of resources in predicting feedback-seeking behavior (FSB) over time. We also examine the relationship between FSB and its outcomes from a systematic review perspective. The eligibility criteria were: (a) to measure feedback-seeking behavior, (b) to have a longitudinal design, and (c) to have employees as target groups. Thirteen studies met these criteria (Ntotal= 1,527). We combined the meta-analysis procedures and structural equation modeling (metaSEM) and used the systematic review. The methodological quality of the available longitudinal studies is assessed. Our findings indicated that job resources predict future feedback-seeking behavior and between feedback-seeking behavior and personal resources is significant relationship. More research is needed to clarify the reciprocal relationships between personal resources and feedback-seeking behavior and the influences of feedback-seeking behavior on performance.


2019 ◽  
Vol 245 ◽  
pp. 152-162 ◽  
Author(s):  
Margalida Gili ◽  
Pere Castellví ◽  
Margalida Vives ◽  
Alejandro de la Torre-Luque ◽  
José Almenara ◽  
...  

2018 ◽  
Vol 4 (1) ◽  
pp. e000409 ◽  
Author(s):  
Barbara Joschtel ◽  
Sjaan R Gomersall ◽  
Sean Tweedy ◽  
Helen Petsky ◽  
Anne B Chang ◽  
...  

IntroductionChronic disease in children is increasing, including the prevalence of chronic respiratory diseases such as asthma, cystic fibrosis (CF), bronchiectasis and bronchopulmonary dysplasia (BPD). The aim of this systematic review and meta-analysis was to evaluate the effects of exercise training on health outcomes in children with chronic respiratory disease.MethodFive databases were searched for randomised controlled trials investigating the effects of exercise training on children with chronic respiratory disease. Following the PRISMA guidelines, eligible studies were identified and data were extracted. A meta-analysis was conducted for the outcomes cardiovascular fitness, lung function and quality of life (QoL).ResultsThe initial search returned 3688 papers. Twenty-seven (17 in children with asthma, 10 in children with CF) were included in the systematic review and 24 of these were included in the meta-analysis. No studies were identified in children with bronchiectasis or BPD. Included papers had a total of 1009 participants aged 8–20 years. In addition to cardiovascular fitness, lung function and QoL, studies also assessed pulmonary function, respiratory muscle strength, muscular strength and inflammation. Meta-analysis showed a large significant effect size in favour of exercise for cardiovascular fitness (peak VO2) (standard mean difference (SMD)=1.16, 95%  CI 0.61 to 1.70) and QoL (SMD=1.27, 95% CI 0.72 to 1.82) as well as a small, non-significant effect size for lung function (FEV1) (SMD=0.02, 95% CI -0.38 to 0.42).ConclusionExercise training significantly improves cardiovascular fitness and QoL in children with asthma and CF. Further research is needed, particularly in children with bronchiectasis and BPD.


BMJ Open ◽  
2020 ◽  
Vol 10 (4) ◽  
pp. e037509
Author(s):  
Kimberley Sonnex ◽  
Hanna Alleemudder ◽  
Roger Knaggs

ObjectivesInhaled corticosteroids (ICS) reduce exacerbation rates and the decline in lung function in people with chronic obstructive pulmonary disease (COPD). There is evidence that smoking causes ‘steroid resistance’ and thus reduces the effect of ICS. This systematic review aimed to investigate the effect of smoking on efficacy of ICS in COPD in terms of lung function and exacerbation rates.DesignSystematic review.Data sourcesAn electronic database search of PubMed, Ovid MEDLINE, Ovid Embase and Cochrane Library (January 2000 to January 2020).Eligibility criteriaFully published randomised controlled trials (RCTs), in the English language, evaluating the use of ICS in COPD adults that stratified the participants by smoking status. Trials that included participants with asthma, lung cancer and pneumonia were excluded. The primary outcome measures were changes in lung function and yearly exacerbation rates.Data extraction and synthesisTwo independent reviewers extracted data and assessed risk of bias using the Cochrane Collaboration’s tool.ResultsSeven studies were identified. Four trials (17 892 participants) recorded change in forced expiratory volume in one second (FEV1) from baseline to up to 30 months after starting treatment. Heavier smokers (>36 pack years) using ICS had a greater decline in FEV1that ranged from −22 mL to −75 mL in comparison to lighter smokers. Smokers using ICS had mixed results in FEV1change: −8 mL to +77 mL in comparison to ex-smokers. Four trials (21 270 participants) recorded difference in COPD exacerbation rates at 52 weeks. The rate ratios favoured more exacerbations in ICS users who were current or heavier smokers than those who were ex-smokers or lighter smokers (0.81 to 0.99 vs 0.92 to 1.29).ConclusionsIn COPD, heavier or current smokers do not gain the same benefit from ICS use on lung function and exacerbation rates as lighter or ex-smokers do, however effects may not be clinically important.PROSPERO registration numberCRD42019121833


2008 ◽  
Vol 118 (11) ◽  
pp. 627-635 ◽  
Author(s):  
Roman Jaeschke ◽  
Paul M. O’Byrne ◽  
Parameswaran Nair ◽  
Filip Mejza ◽  
Wiktoria Leśniak ◽  
...  

Sign in / Sign up

Export Citation Format

Share Document