Endoscopically assisted rectal GIST resection by TAMIS approach

2021 ◽  
Author(s):  
P. Tejedor ◽  
J. Zorrilla ◽  
E. Hurtado ◽  
P. Dujovne ◽  
C. Rey ◽  
...  
Keyword(s):  
Rectal Gist

scholarly journals Middle-aged patient with haematochezia and anaemia presenting with rectal GIST

2021 ◽  
Vol 14 (4) ◽  
pp. e240872
Author(s):  
Dhilip Andrew ◽  
Karthik Shyam ◽  
Jovis Johny ◽  
Rini Jose
Keyword(s):  
Aged Patient ◽  
Middle Aged ◽  
Rectal Gist

TAMIS excision of Rectal GIST following effective treatment with neoadjuvant Imatinib – a video vignette

2020 ◽  
Vol 22 (11) ◽  
pp. 1792-1792
Author(s):  
M. Laurini Zanola ◽  
J. Wright ◽  
M. Viola Malet ◽  
P. Rodríguez Goñi ◽  
J. Monson ◽  
...  
Keyword(s):  
Effective Treatment ◽  
Rectal Gist ◽  
Video Vignette

scholarly journals A CASE OF GIANT RECTAL GIST SUCCESSFULLY RESECTED AFTER NEOADJUVANT THERAPY WITH IMATINIB MESYLATE

2010 ◽  
Vol 71 (7) ◽  
pp. 1806-1811
Author(s):  
Koushi OH ◽  
Norihiro NAKAI ◽  
Toshihiro OKADA ◽  
Yuji IIMURO ◽  
Seiichi HIROTA ◽  
...  
Keyword(s):  
Neoadjuvant Therapy ◽  
Imatinib Mesylate ◽  
Rectal Gist

scholarly journals Rectal Gastrointestinal Stromal Tumor (GIST): About a Rare and Unusual Case

2021 ◽  
Vol 6 (11) ◽  
pp. 814-817
Author(s):  
Abderrahmane Jallouli ◽  
Mariama Jarti ◽  
Marj Zohour Haida ◽  
Mouna El Bouatmani ◽  
Adil Ait Errami ◽  
...  
Keyword(s):  
Gastrointestinal Stromal Tumor ◽  
Kinase Inhibitors ◽  
Stromal Tumor ◽  
Large Tumor ◽  
Lower Rectum ◽  
Local Invasion ◽  
Rectal Gist ◽  
Multidisciplinary Consultation

Rectal gastrointestinal stromal tumors (GIST) are extremely rare, accounting for approximately 0.1% of all rectal tumors. Diagnosis is based on histological and immunohistochemical confirmation. We report the case of a 38-year-old patient with a rectal GIST revealed by chronic rectal bleeding associated with rectal tenesmus, abdominal pain with painful contractions and frequent evacuations evolving in a context of altered general state. Rectoscopy was used to visualize the tumor mass and to take biopsies; their histological and immunohistochemical study revealed a rectal location of a gastrointestinal stromal tumor. The extension assessment was negative. After discussion of the case in a multidisciplinary consultation meeting, management consisted of initially putting the patient on Imatinib given the large tumor size, the degree of local invasion and the location of the mass (lower rectum), with regular follow-up in order to schedule a less invasive surgical resection later. Despite the rarity of rectal GIST, early diagnosis is necessary to avoid progression to locoregional invasion complicating some surgical resections given the anatomical constraints of the pelvic region. Hence the interest of neoadjuvant therapy with tyrosine kinase inhibitors allowing in some cases a decrease in tumor volume, a regression of the degree of local invasion and a decrease in the morbidity of the surgery in order to improve the patient's quality of life.

Recurrent rectal GIST resected successfully after preoperative chemotherapy with imatinib mesylate

2008 ◽  
Vol 13 (4) ◽  
pp. 355-360 ◽  
Author(s):  
Madoka Hamada ◽  
Kazuhide Ozaki ◽  
Tadashi Horimi ◽  
Akihito Tsuji ◽  
Yoshitsugu Nasu ◽  
...  
Keyword(s):  
Imatinib Mesylate ◽  
Preoperative Chemotherapy ◽  
Rectal Gist

scholarly journals Clinicopathological Feetures of Rectal GIST

2004 ◽  
Vol 29 (2) ◽  
pp. 169-173
Author(s):  
Tsuyoshi KONISHI ◽  
Toshiaki WATANABE ◽  
Hirokazu NAGAWA
Keyword(s):  
Rectal Gist

scholarly journals Imatinib mesylate-induced kidney injury in the treatment of a gastrointestinal stromal tumor

2016 ◽  
Vol 4 (1) ◽  
pp. 30
Author(s):  
Kevin Zarrabi ◽  
Keith Sweeny ◽  
Roger Keresztes
Keyword(s):  
Serum Creatinine ◽  
Imatinib Mesylate ◽  
Renal Injury ◽  
Treatment Guidelines ◽  
Kidney Injury ◽  
Current Treatment ◽  
Treatment Modalities ◽  
Drug Discontinuation ◽  
Rare Type ◽  
Rectal Gist

Gastrointestinal stromal tumors (GISTs) are a rare type of neoplasm arising within the gastrointestinal tract. Current treatment guidelines employ target-based therapy and adjuvant treatment with imatinib mesylate. We report a case of imatinib-induced renal injury in a 48-year-old male undergoing adjuvant chemotherapy after surgical resection of a rectal GIST. Upon initiation of imatinib therapy, the patient’s serum creatinine steadily rose and met criteria for kidney injury after twenty months of therapy. Drug discontinuation led to a normalization of renal function, but upon reinitiating therapy the serum creatinine sharply increased again. The patient’s recurrent acute renal injury led to indefinite drug discontinuation. Imatinib toxicities have been well studied; however, there are no reports to date noting its renal effects in the GIST patient population. This case report highlights imatinib as therapy for GISTs, describes an event of imatinib-induced renal injury, and reviews current treatment modalities.

Resected High-Risk Rectal GIST Harboring NTRK1 Fusion: a Case Report and Review of the Literature

2020 ◽  
Author(s):  
Renata D’Alpino Peixoto ◽  
Bruno Amaral Medeiros ◽  
Eduardo Henrique Cronemberger
Keyword(s):  
Case Report ◽  
High Risk ◽  
Review Of The Literature ◽  
Rectal Gist
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