How Can We Better Inform Our Patients about Post‐Heart Transplantation Survival? A Conditional Survival Analysis

Failure intensities in which the evaluation of hazard is based on the observation of an auxiliary random process have become very popular in survival analysis. While their definition is well known, either as the derivative of a conditional failure probability or in the counting process and martingale framework, their relationship to conditional survival functions does not seem to be equally well understood. This paper gives a set of necessary and sufficient conditions for the so-called exponential formula in this context.

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Conditional survival analysis in Korean patients with gastric cancer undergoing curative gastrectomy

BMC Cancer ◽

10.1186/s12885-015-2022-2 ◽

2015 ◽

Vol 15 (1) ◽

Cited By ~ 15

Author(s):

Jin Won Lee ◽

Bandar Ali ◽

Han Mo Yoo ◽

Cho Hyun Park ◽

Kyo Young Song

Keyword(s):

Gastric Cancer ◽

Survival Analysis ◽

Conditional Survival ◽

Curative Gastrectomy ◽

Korean Patients

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Abstract 18971: Heart Transplantation for Adult Patients With Congenital Heart Disease: Are the Outcomes Still Worse Than in the General Population in 2015?

Circulation ◽

10.1161/circ.132.suppl_3.18971 ◽

2015 ◽

Vol 132 (suppl_3) ◽

Author(s):

Diego Moguillansky ◽

Biagio A Pietra ◽

Frederick J Fricker ◽

Mark S Bleiweis

Keyword(s):

Congenital Heart Disease ◽

Survival Analysis ◽

Heart Disease ◽

General Population ◽

Heart Transplantation ◽

Heart Transplant ◽

Congenital Heart ◽

Medium Term ◽

General Group

Introduction: Short and medium term outcome after heart transplantation has steadily improved over the last few decades. Outcomes for adult patients with congenital heart disease (ACHD) who undergo transplantation are generally considered to be less favorable. Hypothesis: We hypothesized that the development of heart teams that specialize in ACHD would lead to improved outcomes after transplantation in this population. Methods: We reviewed the records of all patients undergoing first heart transplant at a university center with a dedicated ACHD team over the last 10 years. Patients undergoing re-transplantation were excluded. We looked at short (30 days) and medium term (1 year) survival after heart transplantation in ACHD patients. Results: Between 1/1/05 and 6/10/15, 258 patients underwent heart transplantation. Of the 258 patients, 17 were re-transplants and were excluded. Of the remaining 241 patients, 12 were ACHD patients and 229 were transplanted for other diagnosis (general group). In the general group 184 of 212 (86.8%) patients were alive at 1 year (the remaining 17 did not have sufficient follow up to be included in the 1-year survival analysis). In the ACHD group 9 of 9 patients (100%) were alive at 1 year. The remaining 3 ACHD patients with insufficient follow up to be included in the 1-year survival analysis were still alive 2.5-9.5 months after transplant, such that all 12 ACHD patients survived at least 30 days and were discharged home after heart transplant. At the end of the study period 160 of 229 (70%) patients were still alive in the general group, compared to 8 of 12 (66.7%) in the ACHD group. Conclusions: Short and medium term survival after heart transplantation appears to be no worse for selected ACHD patients compared to the general population. Larger studies with longer follow up are needed to confirm our findings and clarify the intermediate and long-term outcomes of ACHD patients undergoing heart transplantation in the modern era.

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