scholarly journals Different effects of basal insulin peglispro and insulin glargine on liver enzymes and liver fat content in patients with type 1 and type 2 diabetes

2016 ◽  
Vol 18 ◽  
pp. 50-58 ◽  
Author(s):  
K. Cusi ◽  
A. J. Sanyal ◽  
S. Zhang ◽  
B. J. Hoogwerf ◽  
A. M. Chang ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Insulin Glargine ◽  
Basal Insulin ◽  
Liver Enzymes ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content

Reduced insulin clearance relates to increased liver fat content in recent-onset type 2 diabetes and to impaired glucose control in recent-onset type 1 diabetes

2019 ◽  
Author(s):  
S Antoniou ◽  
OP Zaharia ◽  
P Bobrov ◽  
K Strassburger ◽  
Y Karusheva ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Glucose Control ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Recent Onset ◽  
Onset Type

Reduced insulin clearance relates to increased liver fat content in recent-onset type 2 diabetes and to impaired glucose control in recent-onset type 1 diabetes

2019 ◽  
Author(s):  
Sofia Antoniou ◽  
Oana P Zaharia ◽  
Pavel Bobrov ◽  
Klaus Strassburger ◽  
Yanislava Karusheva ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Glucose Control ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Recent Onset ◽  
Onset Type

Diabetes Remission Clinical Trial (DiRECT)—Plasma Liver Function Tests Reflect Change in Liver Fat Content in Early Type 2 Diabetes

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1834-P
Author(s):  
SVIATLANA V. ZHYZHNEUSKAYA ◽  
AHMAD AL-MRABEH ◽  
CARL PETERS ◽  
ALISON C. BARNES ◽  
KIEREN G. HOLLINGSWORTH ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Clinical Trial ◽  
Liver Function ◽  
Liver Function Tests ◽  
Fat Content ◽  
Diabetes Remission ◽  
Liver Fat ◽  
Early Type ◽  
Liver Fat Content

scholarly journals A carbohydrate-reduced high-protein diet improves HbA1c and liver fat content in weight stable participants with type 2 diabetes: a randomised controlled trial

Diabetologia ◽  
2019 ◽  
Vol 62 (11) ◽  
pp. 2066-2078 ◽  
Author(s):  
Mads J. Skytte ◽  
Amirsalar Samkani ◽  
Amy D. Petersen ◽  
Mads N. Thomsen ◽  
Arne Astrup ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Randomised Controlled Trial ◽  
Controlled Trial ◽  
High Protein Diet ◽  
Fat Content ◽  
Protein Diet ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Randomised Controlled

Liver steatosis coexists with myocardial insulin resistance and coronary dysfunction in patients with type 2 diabetes

2006 ◽  
Vol 291 (2) ◽  
pp. E282-E290 ◽  
Author(s):  
Riikka Lautamäki ◽  
Ronald Borra ◽  
Patricia Iozzo ◽  
Markku Komu ◽  
Terho Lehtimäki ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Liver Steatosis ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Artery Disease ◽  
Myocardial Insulin Resistance ◽  
High Liver

Nonalcoholic fatty liver (NAFL) is a common comorbidity in patients with type 2 diabetes and links to the risk of coronary syndromes. The aim was to determine the manifestations of metabolic syndrome in different organs in patients with liver steatosis. We studied 55 type 2 diabetic patients with coronary artery disease using positron emission tomography. Myocardial perfusion was measured with [15O]H2O and myocardial and skeletal muscle glucose uptake with 2-deoxy-2-[18F]fluoro-d-glucose during hyperinsulinemic euglycemia. Liver fat content was determined by magnetic resonance proton spectroscopy. Patients were divided on the basis of their median (8%) into two groups with low (4.6 ± 2.0%) and high (17.4 ± 8.0%) liver fat content. The groups were well matched for age, BMI, and fasting plasma glucose. In addition to insulin resistance at the whole body level ( P = 0.012) and muscle ( P = 0.002), the high liver fat group had lower insulin-stimulated myocardial glucose uptake ( P = 0.040) and glucose extraction rate ( P = 0.0006) compared with the low liver fat group. In multiple regression analysis, liver fat content was the most significant explanatory variable for myocardial insulin resistance. In addition, the high liver fat group had increased concentrations of high sensitivity C-reactive protein, soluble forms of E-selectin, vascular adhesion protein-1, and intercellular adhesion molecule-1 ( P < 0.05) and lower coronary flow reserve ( P = 0.02) compared with the low liver fat group. In conclusion, in patients with type 2 diabetes and coronary artery disease, liver fat content is a novel independent indicator of myocardial insulin resistance and reduced coronary functional capacity. Further studies will reveal the effect of hepatic fat reduction on myocardial metabolism and coronary function.

scholarly journals The effects of basal insulin peglispro vs. insulin glargine on lipoprotein particles by NMR and liver fat content by MRI in patients with diabetes

2017 ◽  
Vol 16 (1) ◽  
Author(s):  
Trevor J. Orchard ◽  
Bertrand Cariou ◽  
Margery A. Connelly ◽  
James D. Otvos ◽  
Shuyu Zhang ◽  
...  
Keyword(s):  
Insulin Glargine ◽  
Basal Insulin ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Lipoprotein Particles ◽  
Patients With Diabetes

scholarly journals Empagliflozin Effectively Lowers Liver Fat Content in Well-Controlled Type 2 Diabetes: A Randomized, Double-Blind, Phase 4, Placebo-Controlled Trial

Diabetes Care ◽  
2019 ◽  
Vol 43 (2) ◽  
pp. 298-305 ◽  
Author(s):  
Sabine Kahl ◽  
Sofiya Gancheva ◽  
Klaus Straßburger ◽  
Christian Herder ◽  
Jürgen Machann ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Controlled Trial ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Double Blind

Lack of an association between an apolipoprotein C3 genetic variant and the liver fat content in patients with type 2 diabetes

Hepatology ◽  
2011 ◽  
Vol 54 (3) ◽  
pp. 1109-1110 ◽  
Author(s):  
Jean Michel Petit ◽  
Boris Guiu ◽  
David Masson ◽  
Jean-Pierre Cercueil ◽  
Patrick Hillon ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Genetic Variant ◽  
Fat Content ◽  
Liver Fat ◽  
Liver Fat Content ◽  
Apolipoprotein C3

scholarly journals Estimating the Effect of Liver and Pancreas Volume and Fat Content on Risk of Diabetes: A Mendelian Randomization Study

Diabetes Care ◽  
2021 ◽  
Author(s):  
Susan Martin ◽  
Elena P. Sorokin ◽  
E. Louise Thomas ◽  
Naveed Sattar ◽  
Madeleine Cule ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Type 1 Diabetes ◽  
Mendelian Randomization ◽  
Fat Content ◽  
Liver Fat ◽  
Liver And Pancreas ◽  
Pancreas Volume

OBJECTIVE Fat content and volume of liver and pancreas are associated with risk of diabetes in observational studies; whether these associations are causal is unknown. We conducted a Mendelian randomization (MR) study to examine causality of such associations. RESEARCH DESIGN AND METHODS We used genetic variants associated (P &lt; 5 × 10−8) with the exposures (liver and pancreas volume and fat content) using MRI scans of UK Biobank participants (n = 32,859). We obtained summary-level data for risk of type 1 (9,358 cases) and type 2 (55,005 cases) diabetes from the largest available genome-wide association studies. We performed inverse–variance weighted MR as main analysis and several sensitivity analyses to assess pleiotropy and to exclude variants with potential pleiotropic effects. RESULTS Observationally, liver fat and volume were associated with type 2 diabetes (odds ratio per 1 SD higher exposure 2.16 [2.02, 2.31] and 2.11 [1.96, 2.27], respectively). Pancreatic fat was associated with type 2 diabetes (1.42 [1.34, 1.51]) but not type 1 diabetes, and pancreas volume was negatively associated with type 1 diabetes (0.42 [0.36, 0.48]) and type 2 diabetes (0.73 [0.68, 0.78]). MR analysis provided evidence only for a causal role of liver fat and pancreas volume in risk of type 2 diabetes (1.27 [1.08, 1.49] or 27% increased risk and 0.76 [0.62, 0.94] or 24% decreased risk per 1SD, respectively) and no causal associations with type 1 diabetes. CONCLUSIONS Our findings assist in understanding the causal role of ectopic fat in the liver and pancreas and of organ volume in the pathophysiology of type 1 and 2 diabetes.

A high-protein diet reduces liver fat content and improves glomerular filtration rate in subjects with type 2 diabetes

2015 ◽  
Vol 10 (S 01) ◽  
Author(s):  
M Markova ◽  
S Hornemann ◽  
S Sucher ◽  
C Herder ◽  
M Roden ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Glomerular Filtration Rate ◽  
Glomerular Filtration ◽  
Filtration Rate ◽  
High Protein Diet ◽  
Fat Content ◽  
Protein Diet ◽  
Liver Fat ◽  
Liver Fat Content
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