Refractory leg ulcers in prolidase deficiency with antiphospholipid antibody positivity responding to aspirin‐hydroxychloroquine‐vitamin C combination therapy

Background. Some studies with inconclusive results have reported a link between sarcoidosis and an increased risk of pulmonary embolism (PE). This study aimed at assessing a possible correlation between potential risk factors and PE in sarcoidosis patients. Methods. A total of 256 sarcoidosis patients (84 males and 172 females; mean age at diagnosis 49 ± 13) were enrolled after giving written informed consent. Clinical evaluations, laboratory and radiology tests were performed to evaluate the presence of pulmonary embolism. Results. Fifteen sarcoidosis patients with PE (4 males and 11 females; mean age at diagnosis 50 ± 11), diagnosed by lung scintigraphy and 241 sarcoidosis patients without PE (80 males and 161 females; mean age at diagnosis 47 ± 13), were observed. There was a statistically significant increase of the presence of antiphospholipid antibodies in the sarcoidosis group with pulmonary embolism. There was no statistically significant difference between the two groups as to smoking habit, obesity or hereditary thrombophilia frequency (p > 0.05, respectively). Conclusions. This study demonstrates a significant correlation between the presence of antiphospholipid antibody positivity and the pulmonary embolism events in our sarcoidosis patients. Furthermore, we propose screening for these antibodies and monitoring, aimed at timely treatment.

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The relationship of antiphospholipid antibodies to cognitive function in patients with systemic lupus erythematosus

Journal of the International Neuropsychological Society ◽

10.1017/s1355617797003779 ◽

1997 ◽

Vol 3 (4) ◽

pp. 377-386 ◽

Cited By ~ 101

Author(s):

SUSAN D. DENBURG ◽

RAMONA M. CARBOTTE ◽

JEFFREY S. GINSBERG ◽

JUDAH A. DENBURG

Keyword(s):

Systemic Lupus Erythematosus ◽

Lupus Erythematosus ◽

Verbal Memory ◽

Lupus Anticoagulant ◽

Cognitive Test ◽

Antiphospholipid Antibody ◽

Systemic Lupus ◽

Cross Sectional ◽

Antibody Positivity ◽

The Relationship

Objective: To examine the relationship between antiphospholipid antibody positivity (expressed as the lupus anticoagulant) and cognitive dysfunction in patients with systemic lupus erythematosus (SLE). Methods: Cross-sectional comparisons of lupus anticoagulant (LA) positive (N = 39) and negative (N = 79) patients and controls (N = 35) on a cognitive test battery; 22 LA-positive and 53 LA-negative patients who had never experienced neuropsychiatric events (never-NP–SLE) were also compared separately. Results: LA-positive patients were 2 to 3 times more likely than were LA-negative patients to be designated as cognitively impaired. As a group, LA-positive patients, particularly those in the never-NP–SLE group, demonstrated lower performance primarily on tasks of verbal memory, cognitive flexibility, and psychomotor speed. Conclusions: LA positivity is associated with subclinical nervous system compromise, and a pattern of deficits compatible with subcortical involvement, possibly on the basis of ongoing LA-related microthrombotic events or vasculopathy. (JINS, 1997, 3, 377–386.)

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Combination therapy of vitamin C and thiamine for septic shock: a multi-centre, double-blinded randomized, controlled study

Intensive Care Medicine ◽

10.1007/s00134-020-06191-3 ◽

2020 ◽

Vol 46 (11) ◽

pp. 2015-2025 ◽

Cited By ~ 3

Author(s):

Sung Yeon Hwang ◽

◽

Seung Mok Ryoo ◽

Jong Eun Park ◽

You Hwan Jo ◽

...

Keyword(s):

Septic Shock ◽

Combination Therapy ◽

Vitamin C ◽

Randomized Controlled Study ◽

Controlled Study ◽

Randomized Controlled ◽

Double Blinded

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Biomarker Analysis for Combination Therapy of Vitamin C and Thiamine In Septic Shock

Shock ◽

10.1097/shk.0000000000001850 ◽

2021 ◽

Vol Publish Ahead of Print ◽

Author(s):

Jong Eun Park ◽

You Hwan Jo ◽

Sung Yeon Hwang ◽

Won Young Kim ◽

Seung Mok Ryoo ◽

...

Keyword(s):

Septic Shock ◽

Combination Therapy ◽

Vitamin C ◽

Biomarker Analysis

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Hyperbaric oxygen therapy in the management of severe leg ulcers from prolidase deficiency

BMJ Case Reports ◽

10.1136/bcr-2016-217329 ◽

2017 ◽

pp. bcr2016217329 ◽

Cited By ~ 3

Author(s):

Michelangelo Vestita ◽

Giuseppe Giudice ◽

Domenico Bonamonte

Keyword(s):

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy ◽

Leg Ulcers ◽

Prolidase Deficiency

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Combination therapy of vitamin C and phenolics-rich fraction of Khaya senegalensis stem bark extract against Trypanosoma brucei brucei infection

Synergy ◽

10.1016/j.synres.2017.04.001 ◽

2017 ◽

Vol 4 ◽

pp. 19-22

Author(s):

Mohammed Auwal Ibrahim ◽

Aliyu Muhammad Musa ◽

Hassanat Taye Tairu ◽

Maryam Kassim ◽

Abubakar Babando Aliyu ◽

...

Keyword(s):

Combination Therapy ◽

Vitamin C ◽

Trypanosoma Brucei ◽

Stem Bark ◽

Bark Extract ◽

Trypanosoma Brucei Brucei ◽

Khaya Senegalensis ◽

Stem Bark Extract

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Triple positive antiphospholipid antibody profile in outpatients with tests for lupus anticoagulants

Clinical Chemistry and Laboratory Medicine (CCLM) ◽

10.1515/cclm-2014-0571 ◽

2015 ◽

Vol 53 (1) ◽

Author(s):

Paul Froom ◽

Enas Saffuri-Elias ◽

Orit Rozenberg ◽

Mira Barak

Keyword(s):

Antiphospholipid Antibody ◽

Test Results ◽

Serum Igg ◽

Increased Risk ◽

Antibody Positivity ◽

Normal Functional ◽

Single Positive ◽

Antibody Profile ◽

Risk For Thrombosis ◽

Test Result

AbstractA triple positive antiphospholipid (aPL) antibody profile [two positive serum IgG aPL antibodies along with one positive functional plasma lupus anticoagulant (LAC) test result] is associated with an increased risk for thrombosis, whereas patients with single positive test results may have little to no increased risk. The frequency of triple positivity in outpatients with various combinations of LAC test results is unclear.We extracted from our database all LAC test results [dilute Russell viper venom times (dRVVT) and silica clotting times (SCT)] that had concomitant serum IgG aPL testing [both serum anti βThere were 3195 patients without a prolonged prothrombin time. Double antibody positivity was found in 1% (31/2955) of those with normal functional LAC test results, in 16.0% (31/81) of those with a positive dRVVT, in 12.7% (10/79) of those with a positive SCT, and in 56.3% (45/80) of those with both tests positive (p<0.001). A triple positive aPL antibody profile was found in 28.3% (68/240) of those with at least one positive LAC test result.We conclude that 28% of patients with elevated LAC tests have a triple positive aPL antibody profile and patients with two positive LAC tests have a higher prevalence of a triple positive profile than do those with one positive LAC test result.

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