scholarly journals Adolescents with or at ultra-high risk for bipolar disorder exhibit erythrocyte docosahexaenoic acid and eicosapentaenoic acid deficits: a candidate prodromal risk biomarker

2015 ◽  
Vol 10 (3) ◽  
pp. 203-211 ◽  
Author(s):  
Robert K. McNamara ◽  
Ronald Jandacek ◽  
Patrick Tso ◽  
Thomas J. Blom ◽  
Jeffrey A. Welge ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
High Risk ◽  
Docosahexaenoic Acid ◽  
Eicosapentaenoic Acid ◽  
Ultra High Risk

scholarly journals The association between self-reported and clinically determined hypomanic symptoms and the onset of major mood disorders

BJPsych Open ◽  
2017 ◽  
Vol 3 (2) ◽  
pp. 71-77 ◽  
Author(s):  
Sarah Margaret Goodday ◽  
Martin Preisig ◽  
Mehdi Gholamrezaee ◽  
Paul Grof ◽  
Jules Angst ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
High Risk ◽  
Major Depression ◽  
Young People ◽  
Mood Disorders ◽  
Clinical Interviews ◽  
Increased Risk ◽  
Ultra High Risk ◽  
Clinically Significant ◽  
And Control

BackgroundHypomanic symptoms may be a useful predictor of mood disorder among young people at high risk for bipolar disorder.AimsTo determine whether hypomanic symptoms differentiate offspring of parents with bipolar disorder (high risk) and offspring of well parents (control) and predict the development of mood episodes.MethodHigh-risk and control offspring were prospectively assessed using semi-structured clinical interviews annually and completed the Hypomania Checklist-32 Revised (HCL-32). Clinically significant sub-threshold hypomanic symptoms (CSHS) were coded.ResultsHCL-32 total and active or elated scores were higher in control compared with high-risk offspring, whereas 14% of high-risk and 0% of control offspring had CSHS. High-risk offspring with CSHS had a fivefold increased risk of developing recurrent major depression (P=0.0002). The median onset of CSHS in high-risk offspring was 16.4 (6–31) years and was before the onset of major mood episodes.ConclusionsCSHS are precursors to major mood episodes in high-risk offspring and could identify individuals at ultra-high risk for developing bipolar disorder.

scholarly journals A Multi-Dimensional and Integrative Approach to Examining the High-Risk and Ultra-High-Risk Stages of Bipolar Disorder

EBioMedicine ◽  
2015 ◽  
Vol 2 (8) ◽  
pp. 919-928 ◽  
Author(s):  
Kangguang Lin ◽  
Guiyun Xu ◽  
Nichol M.L. Wong ◽  
Huawang Wu ◽  
Ting Li ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
High Risk ◽  
Integrative Approach ◽  
Ultra High Risk

At-risk studies and clinical antecedents of psychosis, bipolar disorder and depression: a scoping review in the context of clinical staging

2018 ◽  
Vol 49 (2) ◽  
pp. 177-189 ◽  
Author(s):  
Jessica A Hartmann ◽  
Barnaby Nelson ◽  
Aswin Ratheesh ◽  
Devi Treen ◽  
Patrick D McGorry
Keyword(s):  
At Risk ◽  
Bipolar Disorder ◽  
Mental Illness ◽  
High Risk ◽  
Scoping Review ◽  
Mental States ◽  
The Body ◽  
Clinical Staging ◽  
Ultra High Risk ◽  
Staging Model

AbstractIdentifying young people at risk of developing serious mental illness and identifying predictors of onset of illness has been a focus of psychiatric prediction research, particularly in the field of psychosis. Work in this area has facilitated the adoption of the clinical staging model of early clinical phenotypes, ranging from at-risk mental states to chronic and severe mental illness. It has been a topic of debate if these staging models should be conceptualised as disorder-specific or transdiagnostic. In order to inform this debate and facilitate cross-diagnostic discourse, the present scoping review provides a broad overview of the body of literature of (a) longitudinal at-risk approaches and (b) identified antecedents of (homotypic) illness progression across three major mental disorders [psychosis, bipolar disorder (BD) and depression], and places these in the context of clinical staging. Stage 0 at-risk conceptualisations (i.e. familial high-risk approaches) were identified in all three disorders. However, formalised stage 1b conceptualisations (i.e. ultra-high-risk approaches) were only present in psychosis and marginally in BD. The presence of non-specific and overlapping antecedents in the three disorders may support a general staging model, at least in the early stages of severe psychotic or mood disorders.

Adverse effects of obesity on cognitive functions in individuals at ultra high risk for bipolar disorder: Results from the global mood and brain science initiative

2017 ◽  
Vol 19 (2) ◽  
pp. 128-134 ◽  
Author(s):  
Roger S. McIntyre ◽  
Rodrigo B. Mansur ◽  
Yena Lee ◽  
Letícia Japiassú ◽  
Kun Chen ◽  
...  
Keyword(s):  
Bipolar Disorder ◽  
High Risk ◽  
Adverse Effects ◽  
Cognitive Functions ◽  
Brain Science ◽  
Ultra High Risk ◽  
Science Initiative

Correlates of electroencephalographic resting states and erythrocyte membrane docosahexaenoic and eicosapentaenoic acid levels in individuals at ultra-high risk of psychosis

2015 ◽  
Vol 50 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Suzie Lavoie ◽  
Thomas J Whitford ◽  
Franz Benninger ◽  
Martha Feucht ◽  
Sung-Wan Kim ◽  
...  
Keyword(s):  
High Risk ◽  
Eicosapentaenoic Acid ◽  
Erythrocyte Membrane ◽  
Ultra High Risk
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