scholarly journals The longevity gene Klotho and its cerebrospinal fluid protein profiles as a modifier for Parkinson´s disease

2021 ◽  
Author(s):  
Milan Zimmermann ◽  
Leonie Köhler ◽  
Marketa Kovarova ◽  
Stefanie Lerche ◽  
Claudia Schulte ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Protein Profiles ◽  
Longevity Gene ◽  
Cerebrospinal Fluid Protein

On-line result interpretation of cerebrospinal fluid protein profiles with the Behring Nephelometer BNA

1988 ◽  
Vol 330 (4-5) ◽  
pp. 373-374 ◽  
Author(s):  
M. Wick ◽  
A. Fateh-Moghadam ◽  
Ch. Przetak ◽  
K. Einhäupl ◽  
M. Knedel ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Protein Profiles ◽  
On Line ◽  
Result Interpretation ◽  
Cerebrospinal Fluid Protein

Cerebrospinal fluid protein findings during prophylaxis and treatment of neuromeningosis in leukaemic patients

1987 ◽  
Vol 47 (8) ◽  
pp. 765-769
Author(s):  
R. Marra ◽  
L. Pagano ◽  
S. Storti ◽  
A. Massaro ◽  
L. Teofili ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Protein

Extremely Elevated Cerebrospinal Fluid Protein and Glucose Level in a Neonate with Hypernatremic Dehydration

2020 ◽  
Author(s):  
Arti Maria ◽  
Tapas Bandyopadhyay
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurodevelopmental Outcome ◽  
Neurological Sequelae ◽  
Glucose Levels ◽  
Csf Analysis ◽  
First Case ◽  
Time Of Admission ◽  
Cerebrospinal Fluid Protein ◽  
Hypernatremic Dehydration

AbstractWe describe the case of a term newborn who presented with hypernatremic dehydration on day 19 of life. The baby was otherwise hemodynamically stable with no evidence of focal or asymmetric neurological signs. The laboratory tests at the time of admission were negative except for hypernatremia and the extremely elevated levels of cerebrospinal fluid (CSF) protein (717 mg/dL) and glucose levels (97 mg/dL). The hypernatremic dehydration was corrected as per the unit protocol over 48 hours. Repeat CSF analysis done after 5 days showed normalization of the protein and glucose levels. Serial follow-up and neuroimaging showed no evidence of neurological sequelae. Unique feature of our case is this is the first case reporting such an extreme elevation of CSF protein and glucose levels that have had no bearing on neurodevelopmental outcome at 1 month and 3 months of follow-up.

An alternative method for assaying cerebrospinal fluid protein in the presence of methotrexate.

1988 ◽  
Vol 34 (10) ◽  
pp. 2091-2092 ◽  
Author(s):  
L M Kasper ◽  
W R Moorehead ◽  
T O Oei ◽  
M Markanich
Keyword(s):  
Cerebrospinal Fluid ◽  
Hydrochloric Acid ◽  
Trichloroacetic Acid ◽  
Dilute Hydrochloric Acid ◽  
Constant Amount ◽  
Manual Method ◽  
Turbidimetric Method ◽  
Methotrexate Concentration ◽  
Cerebrospinal Fluid Protein ◽  
Positive Interference

Abstract Therapeutic concentrations of methotrexate can cause significant positive interference in cerebrospinal fluid (CSF) protein values when assayed in the Du Pont aca. Conversely, our modified turbidimetric method, in which trichloroacetic acid (TCA) plus a sample blank containing dilute hydrochloric acid is used in place of TCA, exhibits little or no interference from methotrexate. This was verified by assaying solutions that contained a constant amount of protein (approximately 430 mg/L) and various amounts of methotrexate (0.0-2.3 x 10(-4) mol/L) by both the Du Pont aca and the manual turbidimetric method. As expected, the aca results showed increasing protein values with increasing methotrexate, whereas the manual method gave results approximating the expected protein value irrespective of the methotrexate concentration.

Resolution of brain edema in severe brain injury at controlled high and low intracranial pressures

1984 ◽  
Vol 61 (4) ◽  
pp. 707-712 ◽  
Author(s):  
Meihong Cao ◽  
He Lisheng ◽  
Sun Shouzheng
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Injury ◽  
Brain Edema ◽  
External Ventricular Drainage ◽  
Blue Dye ◽  
Severe Brain Injury ◽  
Content Type ◽  
Intracranial Pressures ◽  
Low Levels ◽  
Cerebrospinal Fluid Protein

✓ A series of 87 patients with severe brain injury were studied. Intracranial pressure (ICP) monitoring and external ventricular drainage were used to control ICP at high and low levels. Clearance of ytterbium-169-labeled diethylenetriaminepentaacetic acid (169Yb-DTPA), Evans blue dye, and ventricular cerebrospinal fluid protein was measured at the two ICP levels over consecutive periods of 4 hours to confirm clearance of brain edema. The results support the hypothesis that brain edema is in part absorbed in the cerebrospinal fluid via transventricular flow.

THE DIENCEPHALIC SYNDROME OF EARLY INFANCY DUE TO SILENT BRAIN TUMOR: WITH SPECIAL REFERENCE TO TREATMENT

PEDIATRICS ◽  
1966 ◽  
Vol 38 (3) ◽  
pp. 473-482
Author(s):  
Harry W. Bain ◽  
John M. M. Darte ◽  
William S. Keith ◽  
Evert Kruyff
Keyword(s):  
Cerebrospinal Fluid ◽  
Brain Tumor ◽  
Food Intake ◽  
Special Reference ◽  
Eosinophil Count ◽  
Clinical Observation ◽  
Stimulation Test ◽  
Diencephalic Syndrome ◽  
Physical Findings ◽  
Cerebrospinal Fluid Protein

Three patients with typical "diencephalic syndrome" have been described. The clinical observation of an emaciated and pale, but remarkably bright, cheerful, and active infant with a normal or increased appetite and food intake should suggest the diagnosis. Physical findings are conspicuous by their absence, although mild nystagmus, tremor, or ataxia may occasionally be present. An elevated total eosinophil count and an elevated cerebrospinal fluid protein are important, though not invariable, features. Metopirone test coupled with ACTH-adrenal stimulation test indicate markedly reduced pituitary reserve. Diagnosis is confirmed by pneumoencephalography and biopsy. It is likely that with increasing knowledge, the clinical spectrum of this syndrome will be broadened, and one might expect to find, on occasions, anorexia rather than increased appetite, lassitude rather than hyperactivity, irritability rather than euphoria, obesity rather than emaciation, and different combinations of all of these features. The results of therapy with beam-directed cobalt irradiation are encouraging.

LINEAR NEVUS SEBACEOUS SYNDROME: REPORT OF TWO CASES AND A REVIEW OF THE LITERATURE

PEDIATRICS ◽  
1973 ◽  
Vol 52 (3) ◽  
pp. 382-387
Author(s):  
Frederick H. Lovejoy ◽  
William E. Boyle
Keyword(s):  
Cerebrospinal Fluid ◽  
Neurologic Disease ◽  
Review Of The Literature ◽  
Cutaneous Lesions ◽  
Neurocutaneous Syndromes ◽  
Nevus Sebaceous ◽  
Cerebrospinal Fluid Protein ◽  
Syndrome Report

Two cases of linear nevus sebaceous syndrome are described and a review of the eleven cases now reported in the literature is undertaken. The first patient has retardation, seizures, and classic ectodermal lesions while the second patient manifests typical cutaneous lesions and only an elevated cerebrospinal fluid protein as evidence of neurologic disease. The rationale for defining the syndrome as an entity distinct from other neurocutaneous syndromes is discussed and a pleomorphic presentation of the syndrome is suggested.

scholarly journals Clinical Prognosis in Neonatal Bacterial Meningitis: The Role of Cerebrospinal Fluid Protein

PLoS ONE ◽  
2015 ◽  
Vol 10 (10) ◽  
pp. e0141620 ◽  
Author(s):  
Jintong Tan ◽  
Juan Kan ◽  
Gang Qiu ◽  
Dongying Zhao ◽  
Fang Ren ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Bacterial Meningitis ◽  
Clinical Prognosis ◽  
Cerebrospinal Fluid Protein

Interference by metrizamide with the Du Pont aca method for cerebrospinal fluid protein.

1983 ◽  
Vol 29 (2) ◽  
pp. 395-396
Author(s):  
R L Sunheimer ◽  
L P Gordon ◽  
P J Howanitz ◽  
J H Howanitz
Keyword(s):  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Protein

scholarly journals Cerebrospinal Fluid Protein Concentration in Healthy Older Japanese Volunteers

2021 ◽  
Vol 18 (16) ◽  
pp. 8683
Author(s):  
Tatsuya Yoshihara ◽  
Masayoshi Zaitsu ◽  
Kazuya Ito ◽  
Ryuzo Hanada ◽  
Eunhee Chung ◽  
...  
Keyword(s):  
Cerebrospinal Fluid ◽  
Asian Population ◽  
Reference Interval ◽  
Reference Limit ◽  
Neurological Emergencies ◽  
Precise Diagnosis ◽  
The Mean ◽  
Upper Reference Limit ◽  
Age Range ◽  
Cerebrospinal Fluid Protein

The concentration of cerebrospinal fluid total protein (CSF-TP) is important for the diagnosis of neurological emergencies. Recently, some Western studies have shown that the current upper reference limit of CSF-TP is quite low for older patients. However, little is reported about the concentration of CSF-TP in the older Asian population. In this study, we retrospectively analyzed the CSF-TP concentrations in healthy older Japanese volunteers. CSF samples in 69 healthy Japanese volunteers (age range: 55–73 years) were collected by lumbar puncture, and the data of CSF were retrospectively analyzed. The mean (standard deviation) CSF-TP was 41.7 (12.3) mg/dL. The older group (≥65 years old) had higher CSF-TP concentration than the younger group (55–64 years old). The 2.5th percentile and 97.5th percentile of CSF-TP were estimated as 22.5 and 73.2 mg/dL, respectively, which were higher than the current reference range in Japan (10–40 mg/dL). Conclusions: The reference interval of CSF-TP in the older population should be reconsidered for the precise diagnosis of neurological emergencies.

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