Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study

2018 ◽  
Vol 126 (6) ◽  
pp. 485-492 ◽  
Author(s):  
Petra Borilova Linhartova ◽  
Julius Janos ◽  
Simona Slezakova ◽  
Jirina Bartova ◽  
Jitka Petanova ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Gene Variability ◽  
Control Study

scholarly journals Mannose-binding lectin serum levels and (Gly54asp) gene polymorphism in recurrent aphthous stomatitis: A case-control study

2021 ◽  
Vol 35 ◽  
pp. 205873842110644
Author(s):  
Shereen A Baioumy ◽  
Shaimaa H Fouad ◽  
Shaimaa A Abdalgeleel ◽  
Ahmed A Baiomy ◽  
Dina E Sallam ◽  
...  
Keyword(s):  
Case Control Study ◽  
Serum Levels ◽  
Case Control ◽  
Recurrent Aphthous Stomatitis ◽  
Mannose Binding Lectin ◽  
Aphthous Stomatitis ◽  
Control Group ◽  
Mannose Binding ◽  
Binding Lectin ◽  
Control Study

Objectives: Dysregulation of the immune response appears to play a significant role in recurrent aphthous stomatitis (RAS) development. The main objective of this case–control study is to investigate the blood levels of mannose-binding lectin (MBL) and the frequency of the MBL2 gene (gly54asp) polymorphism in RAS patients, including 40 RAS patients and 40 healthy controls. Methods: Serum MBL levels were determined by ELISA, while the PCR-restriction fragment length polymorphism was used in MBL2 genotyping. Results: The median serum MBL level was significantly lower in the RAS group than in the control group (975 ng/mL (545–1320) vs. 1760 ng/mL (1254–2134); p≤ 0.001). The MBL levels were significantly lower in the BB genotype, whereas they were significantly higher in the wild type AA with a median of 525 and 1340 ng/mL, respectively ( p =0.005). The B allele was expressed in significantly higher percentages of RAS patients than in controls. There was no significant association between MBL serum levels ( p=0.685) or MBL2 codon 54 genotypes ( p=0.382) with the type of ulcers. Conclusion: There was an association between low MBL serum levels and the variant allele B of the MBL2 (gly54asp) gene, and the susceptibility to RAS. As a result, potential novel therapeutic options for RAS patients with MBL deficiency should be investigated.

scholarly journals Comorbidity profiles among patients with recurrent aphthous stomatitis: A case–control study

2019 ◽  
Vol 118 (3) ◽  
pp. 664-670 ◽  
Author(s):  
Kuan-Chou Lin ◽  
Lo Lin Tsai ◽  
Edward Chengchuan KO ◽  
Kevin Sheng-Po Yuan ◽  
Szu-Yuan Wu
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Control Study

scholarly journals Adipokine gene variability and plasma levels in patients with chronic periodontitis -a case-control study

2019 ◽  
Vol 33 ◽  
Author(s):  
Petra Borilova Linhartova ◽  
Julius Janos ◽  
Hana Poskerova ◽  
Denisa Kavrikova ◽  
Antonin Fassmann ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Plasma Levels ◽  
Case Control Study ◽  
Case Control ◽  
Gene Variability ◽  
Control Study

scholarly journals Salivary proteome of aphthous stomatitis reveals the participation of vitamin metabolism, nutrients, and bacteria

2021 ◽  
Author(s):  
Romina Hernandez-Olivos ◽  
Mariagrazia Munoz ◽  
Esteban Nunez ◽  
Paola Andrea Camargo-Ayala ◽  
Jenaro Garcia-Huidobro ◽  
...  
Keyword(s):  
Metabolic Pathways ◽  
Case Control Study ◽  
Recurrent Aphthous Stomatitis ◽  
Aphthous Stomatitis ◽  
Biological Processes ◽  
Oral Ulcers ◽  
Vitamin B9 ◽  
Poor Understanding ◽  
Control Study ◽  
Carbonic Anhydrase 1

There are currently no preventative options for recurrent aphthous stomatitis, and the only available treatments are palliative. This is partly due to a poor understanding of its etiopathogenesis. In this case-control study, we characterized the salivary proteome of patients with recurrent aphthous stomatitis in the presence and absence of lesions. Through mass spectrometry-based proteomics and bioinformatics tools, we identified that the presence of oral ulcers is associated with several specific biological processes, including the metabolic pathways of vitamin B9, B12, nitrogen, selenium, and the bacterium Neisseria meningitidis. These changes occurred only in the presence of clinically visible lesions, and there were no relevant differences between patients in anatomical regions unaffected by ulcers. Additionally, using western blot and ELISA assays, we verified that carbonic anhydrase 1 (CA1, UniProtKB - P00915, CAH1_HUMAN) and hemoglobin subunit beta (HBB, UniProtKB - P68871, HBB_HUMAN) proteins are highly expressed during the ulcerative and remission phases of recurrent aphthous stomatitis. Our results cumulatively support saliva as an indicator of the pathophysiological changes, which occur during the clinical course of lesions. From a clinical perspective, we suggest that recurrent aphthous stomatitis is a condition triggered by temporary biological changes in people with lesions.

Sign in / Sign up

Export Citation Format

Share Document