Mean platelet volume as a predictor in the differentiation of Behçet's disease from recurrent aphthous stomatitis – a single center, prospective, case‐control study

Background: Neonatal sepsis is the third leading cause of neonatal mortality after prematurity and intrapartum related complications worldwide. The literature regarding the use of Mean platelet volume as a diagnostic tool in neonatal sepsis is scanty.Methods: Prospective case control study in a district hospital. Neonates > 30 weeks gestation admitted to NICU during the study period were included. Neonates who did not have any risk factors for sepsis and did not have a positive blood culture or elevated CRP were categorized as group 1. Neonates who were admitted with risk factors of sepsis but did not have a positive CRP or blood culture positivity were categorized as group 2. Neonates who were admitted as probable sepsis and subsequently developed blood culture or CRP positivity were categorized as group 3.Septic workup was done for all the subjects at admission and at 72 hours after admission. Newborn with congenital anomalies and who were already on antibiotics prior to admission were excluded from the study. Statistical analysis was done using Statistical Package of Social Sciences (SPSS) version 20.0.Results: Total 240 Neonates were included in the study. Elevation of MPV in neonates with sepsis was seen as early as the first sample whereas CRP elevation was seen only on Day 3. Cut off value for Mean Platelet Volume (MPV) was found to be 10.15fl with sensitivity of 84% and specificity of 74%.Conclusions: MPV can be used as a earliest diagnostic marker for prediction of neonatal sepsis and mortality. It can facilitate early initiation of treatment without any additional exposure.

Download Full-text

Recurrent aphthous stomatitis and gene variability in selected interleukins: a case-control study

European Journal Of Oral Sciences ◽

10.1111/eos.12577 ◽

2018 ◽

Vol 126 (6) ◽

pp. 485-492 ◽

Cited By ~ 2

Author(s):

Petra Borilova Linhartova ◽

Julius Janos ◽

Simona Slezakova ◽

Jirina Bartova ◽

Jitka Petanova ◽

...

Keyword(s):

Case Control Study ◽

Case Control ◽

Recurrent Aphthous Stomatitis ◽

Aphthous Stomatitis ◽

Gene Variability ◽

Control Study

Download Full-text

A pattern of platelet indices as a potential marker for prediction of pre-eclampsia among pregnant women attending a Tertiary Hospital, Ethiopia: A case-control study

PLoS ONE ◽

10.1371/journal.pone.0259543 ◽

2021 ◽

Vol 16 (11) ◽

pp. e0259543

Author(s):

Solomon Gebre Bawore ◽

Wondimagegn Adissu ◽

Berhanu Niguse ◽

Yilma Markos Larebo ◽

Nigussie Abebe Ermolo ◽

...

Keyword(s):

Platelet Count ◽

Pregnant Women ◽

Mean Platelet Volume ◽

Case Control Study ◽

Case Control ◽

Platelet Distribution Width ◽

Platelet Volume ◽

Distribution Width ◽

Platelet Indices ◽

Control Study

Introduction Preeclampsia is the most serious health risk during pregnancy for both the mother and the fetus. Even though platelet parameters are among the proposed biomarkers for the prediction of preeclampsia, the use of its indices in the diagnosis of preeclampsia is not increasing in Ethiopia. There is little information on platelet patterns in preeclampsia and normal pregnancy. The purpose of this study was to determine the pattern of platelet indices in women with preeclampsia in our study setting. Methods A case-control study was conducted among 180 pregnant women who attended anti-natal follow-ups from January 1 to April 3, 2019. An Ethylene Diamine Tetra Acetic Acid anti-coagulated venous blood was collected and analyzed using a hematology analyzer (MINDRAY®-BC-300Plus, Shenzhen China). The SPSS software version 26 was used to run the Mann Whitney U test, Kruskal-Wallis H test, and Kolmogorov-Smirnov normality test, Post-hock test augmented with Benforeni, receiver operating characteristics curve, and Spear Man rank-order correlation. A P-value of <0.05 was considered statistically significant. Results A total of 180 pregnant women were included in the study. Platelet count and platelet crit levels tend to decrease as pre-eclampsia becomes more severe. In contrast, the mean platelet volume and platelet distribution widths were significantly increased with the severity of preeclampsia (P<0.001). Platelet distribution width (rho = 0.731, p<0.001) and mean platelet volume (rho = 0.674, p<0.001) had statistically significant positive relationships with mean arterial pressure. The best metric for predicting preeclampsia was platelet distribution width (AUC = 0.986; 95%CI; 0.970, 1). Conclusions Platelet indices, including platelet count, mean platelet volume, platelet distribution width, and Platelet crit, have been identified as promising candidate markers for predicting preeclampsia in pregnant women. In the future, a serial examination of these indicators during several trimesters of pregnancy should be conducted.

Download Full-text

Chlamydophila psittaciis viable and infectious in the conjunctiva and peripheral blood of patients with ocular adnexal lymphoma: Results of a single‐center prospective case–control study

International Journal of Cancer ◽

10.1002/ijc.23596 ◽

2008 ◽

Vol 123 (5) ◽

pp. 1089-1093 ◽

Cited By ~ 42

Author(s):

Andrés J.M. Ferreri ◽

Riccardo Dolcetti ◽

Giuseppina P. Dognini ◽

Lucia Malabarba ◽

Nadia Vicari ◽

...

Keyword(s):

Peripheral Blood ◽

Case Control Study ◽

Case Control ◽

Single Center ◽

Ocular Adnexal Lymphoma ◽

Control Study ◽

Prospective Case Control Study

Download Full-text

Mannose-binding lectin serum levels and (Gly54asp) gene polymorphism in recurrent aphthous stomatitis: A case-control study

International Journal of Immunopathology and Pharmacology ◽

10.1177/20587384211064454 ◽

2021 ◽

Vol 35 ◽

pp. 205873842110644

Author(s):

Shereen A Baioumy ◽

Shaimaa H Fouad ◽

Shaimaa A Abdalgeleel ◽

Ahmed A Baiomy ◽

Dina E Sallam ◽

...

Keyword(s):

Case Control Study ◽

Serum Levels ◽

Case Control ◽

Recurrent Aphthous Stomatitis ◽

Mannose Binding Lectin ◽

Aphthous Stomatitis ◽

Control Group ◽

Mannose Binding ◽

Binding Lectin ◽

Control Study

Objectives: Dysregulation of the immune response appears to play a significant role in recurrent aphthous stomatitis (RAS) development. The main objective of this case–control study is to investigate the blood levels of mannose-binding lectin (MBL) and the frequency of the MBL2 gene (gly54asp) polymorphism in RAS patients, including 40 RAS patients and 40 healthy controls. Methods: Serum MBL levels were determined by ELISA, while the PCR-restriction fragment length polymorphism was used in MBL2 genotyping. Results: The median serum MBL level was significantly lower in the RAS group than in the control group (975 ng/mL (545–1320) vs. 1760 ng/mL (1254–2134); p≤ 0.001). The MBL levels were significantly lower in the BB genotype, whereas they were significantly higher in the wild type AA with a median of 525 and 1340 ng/mL, respectively ( p =0.005). The B allele was expressed in significantly higher percentages of RAS patients than in controls. There was no significant association between MBL serum levels ( p=0.685) or MBL2 codon 54 genotypes ( p=0.382) with the type of ulcers. Conclusion: There was an association between low MBL serum levels and the variant allele B of the MBL2 (gly54asp) gene, and the susceptibility to RAS. As a result, potential novel therapeutic options for RAS patients with MBL deficiency should be investigated.

Download Full-text