scholarly journals THE CONTRIBUTION OF SPONTANEOUS MUTATIONS TO THERMAL SENSITIVITY CURVE VARIATION INDROSOPHILA SERRATA

Evolution ◽  
2014 ◽  
Vol 68 (6) ◽  
pp. 1824-1837 ◽  
Author(s):  
Camille A. L. Latimer ◽  
Katrina McGuigan ◽  
Robbie S. Wilson ◽  
Mark W. Blows ◽  
Stephen F. Chenoweth
Keyword(s):  
Thermal Sensitivity ◽  
Spontaneous Mutations ◽  
Sensitivity Curve ◽  
Curve Variation

Hearing in Mice via GSR Audiometry

1963 ◽  
Vol 6 (4) ◽  
pp. 359-368 ◽  
Author(s):  
Charles I. Berlin
Keyword(s):  
Inverse Relationship ◽  
Sound Pressure ◽  
Single Units ◽  
Sensitivity Curve ◽  
Basic Tool ◽  
Eighth Nerve ◽  
Pure Tones ◽  
Conditioned Responses ◽  
Frequency Intensity ◽  
Near Threshold

Hearing in mice has been difficult to measure behaviorally. With GSR as the basic tool, the sensitivity curve to pure tones in mice has been successfully outlined. The most sensitive frequency-intensity combination was 15 000 cps at 0-5 dB re: 0.0002 dyne/cm 2 , with responses noted from 1 000 to beyond 70 000 cps. Some problems of reliability of conditioning were encountered, as well as findings concerning the inverse relationship between the size of GSR to unattenuated tones and the sound pressure necessary to elicit conditioned responses at or near threshold. These data agree well with the sensitivity of single units of the eighth nerve of the mouse.

Modelling the static thermal sensitivity of diaphragm-based fibre optic pressure sensors

2005 ◽  
Author(s):  
Ahmad Sharifian ◽  
Stuart Watson ◽  
David Buttsworth ◽  
James Barton
Keyword(s):  
Thermal Sensitivity ◽  
Pressure Sensors ◽  
Fibre Optic

scholarly journals An extensive photometric study of the Blazhko RR Lyrae star RZ Lyr*

2012 ◽  
Vol 423 (2) ◽  
pp. 993-1005 ◽  
Author(s):  
J. Jurcsik ◽  
Á. Sódor ◽  
G. Hajdu ◽  
B. Szeidl ◽  
Á. Dózsa ◽  
...  
Keyword(s):  
Light Curve ◽  
Light Curves ◽  
Stellar Structure ◽  
Time Base ◽  
Photometric Method ◽  
Physical Parameters ◽  
Component Solution ◽  
Rr Lyrae ◽  
Curve Variation ◽  
Type Variable

Abstract The analysis of recent, extended multicolour CCD and archive photoelectric, photographic and visual observations has revealed several important properties of RZ Lyr, an RRab-type variable exhibiting large-amplitude Blazhko modulation. On the time base of ∼110 yr, a strict anticorrelation between the pulsation- and modulation-period changes is established. The light curve of RZ Lyr shows a remarkable bump on the descending branch in the small-amplitude phase of the modulation, similarly to the light curves of bump Cepheids. We speculate that the stellar structure temporally suits a 4:1 resonance between the periods of the fundamental and one of the higher order radial modes in this modulation phase. The light-curve variation of RZ Lyr can be correctly fitted with a two-modulation-component solution; the 121-d period of the main modulation is nearly but not exactly four times longer than the period of the secondary modulation component. Using the inverse photometric method, the variations in the pulsation-averaged values of the physical parameters in different phases of both modulation components are determined.

scholarly journals Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function

2021 ◽  
Vol 10 (2) ◽  
pp. 239
Author(s):  
Dalia Rega ◽  
Mika Aiko ◽  
Nicolás Peñaranda ◽  
Amparo Urios ◽  
Juan-José Gallego ◽  
...  
Keyword(s):  
Nervous System ◽  
Hepatic Encephalopathy ◽  
Quantitative Sensory Testing ◽  
Autonomic Function ◽  
Thermal Sensitivity ◽  
Somatosensory System ◽  
Minimal Hepatic Encephalopathy ◽  
Heat Pain ◽  
Sensory Testing ◽  
Cirrhotic Patients

Cirrhotic patients may experience alterations in the peripheral nervous system and in somatosensory perception. Impairment of the somatosensory system could contribute to cognitive and motor alterations characteristic of minimal hepatic encephalopathy (MHE), which affects up to 40% of cirrhotic patients. We assessed the relationship between MHE and alterations in thermal, vibration, and/or heat pain sensitivity in 58 cirrhotic patients (38 without and 20 with MHE according to Psychometric Hepatic Encephalopathy Score) and 39 controls. All participants underwent attention and coordination tests, a nerve conduction study, autonomic function testing, and evaluation of sensory thresholds (vibration, cooling, and heat pain detection) by electromyography and quantitative sensory testing. The detection thresholds for cold and heat pain on the foot were higher in patients with, than those without MHE. This hyposensitivity was correlated with attention deficits. Reaction times in the foot were longer in patients with, than without MHE. Patients with normal sural nerve amplitude showed altered thermal sensitivity and autonomic function, with stronger alterations in patients with, than in those without MHE. MHE patients show a general decrease in cognitive and sensory abilities. Small fibers of the autonomic nervous system and thermal sensitivity are altered early on in MHE, before large sensory fibers. Quantitative sensory testing could be used as a marker of MHE.

scholarly journals Genomic variation in the American pika: signatures of geographic isolation and implications for conservation

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Kelly B. Klingler ◽  
Joshua P. Jahner ◽  
Thomas L. Parchman ◽  
Chris Ray ◽  
Mary M. Peacock
Keyword(s):  
Genetic Variation ◽  
Genetic Structure ◽  
Sierra Nevada ◽  
Spatial Genetic Structure ◽  
Spatial Scales ◽  
Thermal Sensitivity ◽  
Genomic Variation ◽  
Genome Wide ◽  
A Genome ◽  
American Pika

Abstract Background Distributional responses by alpine taxa to repeated, glacial-interglacial cycles throughout the last two million years have significantly influenced the spatial genetic structure of populations. These effects have been exacerbated for the American pika (Ochotona princeps), a small alpine lagomorph constrained by thermal sensitivity and a limited dispersal capacity. As a species of conservation concern, long-term lack of gene flow has important consequences for landscape genetic structure and levels of diversity within populations. Here, we use reduced representation sequencing (ddRADseq) to provide a genome-wide perspective on patterns of genetic variation across pika populations representing distinct subspecies. To investigate how landscape and environmental features shape genetic variation, we collected genetic samples from distinct geographic regions as well as across finer spatial scales in two geographically proximate mountain ranges of eastern Nevada. Results Our genome-wide analyses corroborate range-wide, mitochondrial subspecific designations and reveal pronounced fine-scale population structure between the Ruby Mountains and East Humboldt Range of eastern Nevada. Populations in Nevada were characterized by low genetic diversity (π = 0.0006–0.0009; θW = 0.0005–0.0007) relative to populations in California (π = 0.0014–0.0019; θW = 0.0011–0.0017) and the Rocky Mountains (π = 0.0025–0.0027; θW = 0.0021–0.0024), indicating substantial genetic drift in these isolated populations. Tajima’s D was positive for all sites (D = 0.240–0.811), consistent with recent contraction in population sizes range-wide. Conclusions Substantial influences of geography, elevation and climate variables on genetic differentiation were also detected and may interact with the regional effects of anthropogenic climate change to force the loss of unique genetic lineages through continued population extirpations in the Great Basin and Sierra Nevada.

scholarly journals On the Average Coefficient of Dominance of Deleterious Spontaneous Mutations

Genetics ◽  
2000 ◽  
Vol 155 (4) ◽  
pp. 1991-2001 ◽  
Author(s):  
A García-Dorado ◽  
A Caballero
Keyword(s):  
Deleterious Mutations ◽  
Spontaneous Mutations ◽  
Partial Dominance ◽  
High Viability ◽  
Significant Difference ◽  
Plausible Hypothesis ◽  
Average Coefficient ◽  
Series Of Experiments ◽  
Very High ◽  
Balancer Chromosome

Abstract T. Mukai and co-workers in the late 1960s and O. Ohnishi in the 1970s carried out a series of experiments to obtain direct estimates of the average coefficient of dominance (h¯) of minor viability mutations in Drosophila melanogaster. The results of these experiments, although inconsistent, have been interpreted as indicating slight recessivity of deleterious mutations, with h¯≈0.4. Mukai obtained conflicting results depending on the type of heterozygotes used, some estimates suggesting overdominance and others partial dominance. Ohnishi's estimates, based on the ratio of heterozygous to homozygous viability declines, were more consistent, pointing to the above value. However, we have reanalyzed Ohnishi's data, estimating h¯ by the regression method, and obtained a much smaller estimate of ~0.1. This significant difference can be due partly to the different weighting implicit in the estimates, but we suggest that this is not the only explanation. We propose as a plausible hypothesis that a putative nonmutational decline in viability occurring in the first half of Ohnishi's experiment (affecting both homozygotes and heterozygotes) has biased upward the estimates from the ratio, while it would not bias the regression estimates. This hypothesis also explains the very high h¯≈0.7 observed in Ohnishi's high-viability chromosomes. By constructing a model of spontaneous mutations using parameters in the literature, we investigate the above possibility. The results indicate that a model of few mutations with moderately large effects and h¯≈0.2 is able to explain the observed estimates and the distributions of homozygous and heterozygous viabilities. Accounting for an expression of mutations in genotypes with the balancer chromosome Cy does not alter the conclusions qualitatively.

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