scholarly journals Cannabinoid receptor 1 (CNR1) gene variant moderates neural index of cognitive disruption during nicotine withdrawal

2016 ◽  
Vol 15 (7) ◽  
pp. 621-626 ◽  
Author(s):  
D. E. Evans ◽  
S. K. Sutton ◽  
K. G. Jentink ◽  
H.-Y. Lin ◽  
J. Y. Park ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Nicotine Withdrawal ◽  
Gene Variant ◽  
Cannabinoid Receptor 1 ◽  
Cnr1 Gene

scholarly journals Association study of Cannabinoid receptor 1 (CNR1) gene in tardive dyskinesia

2011 ◽  
Vol 12 (3) ◽  
pp. 260-266 ◽  
Author(s):  
A K Tiwari ◽  
C C Zai ◽  
O Likhodi ◽  
A N Voineskos ◽  
H Y Meltzer ◽  
...  
Keyword(s):  
Tardive Dyskinesia ◽  
Association Study ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1 ◽  
Cnr1 Gene

Relationship between the 1359 G/A polymorphism of the Central Cannabinoid Receptor 1 (CNR1) gene and susceptibility to cannabis addiction in a Turkish population

2014 ◽  
Vol 47 (2) ◽  
pp. 230-238 ◽  
Author(s):  
Aysun Baransel Isir ◽  
Muradiye Nacak ◽  
Sibel Oguzkan Balci ◽  
Sacide Pehlivan ◽  
Seval Kul ◽  
...  
Keyword(s):  
Cannabinoid Receptor ◽  
Turkish Population ◽  
Cannabinoid Receptor 1 ◽  
Cnr1 Gene

Cannabinoid receptor 1 (CNR1) gene: Impact on antidepressant treatment response and emotion processing in Major Depression

2008 ◽  
Vol 18 (10) ◽  
pp. 751-759 ◽  
Author(s):  
Katharina Domschke ◽  
Udo Dannlowski ◽  
Patricia Ohrmann ◽  
Bruce Lawford ◽  
Jochen Bauer ◽  
...  
Keyword(s):  
Major Depression ◽  
Treatment Response ◽  
Cannabinoid Receptor ◽  
Antidepressant Treatment ◽  
Emotion Processing ◽  
Cannabinoid Receptor 1 ◽  
Cnr1 Gene

The cannabinoid receptor 1 gene (CNR1) and multiple sclerosis: an association study in two case-control groups from Spain

2009 ◽  
Vol 16 (2) ◽  
pp. 139-146 ◽  
Author(s):  
E. Ramil ◽  
AJ Sánchez ◽  
P. González-Pérez ◽  
A. Rodríguez-Antigüedad ◽  
N. Gómez-Lozano ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Cannabinoid Receptor ◽  
Endocannabinoid System ◽  
Case Control ◽  
Genotype Distribution ◽  
Cannabinoid Receptor 1 ◽  
Control Groups ◽  
Gene Encoding ◽  
Significant Difference ◽  
Cnr1 Gene

Different studies point to the implication of the endocannabinoid system in multiple sclerosis (MS) and animal models of MS. The purpose of this study was to evaluate a possible association of MS with polymorphic markers at the CNR1 gene, encoding the cannabinoid 1 (CB1) receptor. We have performed a genetic analysis of an AAT repeat microsatellite localized in the downstream region of the CNR1 gene, in two case—control groups of MS patients and healthy controls (HC) from Spain (Madrid and Bilbao). MS patients with primary progressive MS (PPMS) had more commonly long ((AAT) ≥13) alleles and genotypes with a significant difference for genotype 7/8 in Madrid (p = 0.043) and in the sum of both groups (p = 0.016); short alleles were less frequently found in PPMS with a significant difference for allele 5 in the analysis of both groups together (p = 0.039). In patients with relapsing MS, no consistent differences in allele and genotype distribution were found. Disease severity and progression was unrelated to AAT repeat variations. In conclusion, long (AAT) ≥13 CNR1 genotypes could behave as risk factors for PPMS.

scholarly journals Association of a Variant of CNR1 Gene Encoding Cannabinoid Receptor 1 With Gilles de la Tourette Syndrome

2020 ◽  
Vol 11 ◽  
Author(s):  
Natalia Szejko ◽  
Jakub Piotr Fichna ◽  
Krzysztof Safranow ◽  
Tomasz Dziuba ◽  
Cezary Żekanowski ◽  
...  
Keyword(s):  
Tourette Syndrome ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1 ◽  
Gene Encoding ◽  
Cnr1 Gene

scholarly journals A Common Polymorphism in the Cannabinoid Receptor 1 (CNR1) Gene is Associated with Antipsychotic-Induced Weight Gain in Schizophrenia

2010 ◽  
Vol 35 (6) ◽  
pp. 1315-1324 ◽  
Author(s):  
Arun K Tiwari ◽  
Clement C Zai ◽  
Olga Likhodi ◽  
Annika Lisker ◽  
Deepika Singh ◽  
...  
Keyword(s):  
Weight Gain ◽  
Cannabinoid Receptor ◽  
Cannabinoid Receptor 1 ◽  
Common Polymorphism ◽  
Cnr1 Gene

scholarly journals Human Adipose Tissue Cannabinoid Receptor 1 Gene Expression Is Not Related to Fat Cell Function or Adiponectin Level

2007 ◽  
Vol 92 (4) ◽  
pp. 1555-1559 ◽  
Author(s):  
Patrik Löfgren ◽  
Eva Sjölin ◽  
Kerstin Wåhlen ◽  
Johan Hoffstedt
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Cell Function ◽  
Cannabinoid Receptor ◽  
Human Adipose Tissue ◽  
Mrna Levels ◽  
Fat Cell ◽  
Cannabinoid Receptor 1 ◽  
Omental Fat ◽  
Cnr1 Gene

Abstract Context: The cannabinoid receptor 1 gene (CNR1) is implicated in adipocyte function. Objective: We investigated human adipose tissue CNR1 mRNA in relation to obesity, clinical and metabolic variables, adipocyte function, and adiponectin (ADIPOQ) levels. Methods: We assessed sc fat biopsies from 96 obese and nonobese subjects and omental fat biopsies from 82 obese and nonobese subjects. Results: The sc and omental adipose CNR1 gene expression were similar in obese and nonobese subjects. No association between either sc or omental adipose CNR1 mRNA levels and body mass index, waist circumference, plasma levels of glucose and insulin, lipids, or blood pressure was found. The sc and omental maximal adrenergic lipolytic activation as well as lipolytic adrenoceptor sensitivity were not related to CNR1 gene expression. Lipogenesis in sc adipocytes also showed no association with CNR1 mRNA levels. Finally, no relation was found between adipose CNR1 gene expression and ADIPOQ mRNA, adipose tissue adiponectin secretion, or circulating adiponectin. Conclusion: We found no association of human adipose tissue CNR1 mRNA expression with measures of body fat, metabolic parameters, fat cell function, or ADIPOQ expression. These data do not suggest a major role of human adipose CNR1 in fat cell function or metabolic disease development.

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