Relationship between advanced glycation end-product accumulation and low skeletal muscle mass in Japanese men and women

Abstract Background The accumulation of advanced glycation end product (AGE) might exert deleterious effects on musculoskeletal properties. Our study aims to clarify this possible association in a large general population. Methods This study investigated a general population of 9,203 patients (mean age, 57.8 years). Skeletal muscle mass was measured by bioelectrical impedance analysis, whereas accumulation of AGEs was assessed by skin autofluorescence (SAF-AGE). The muscle strength of upper and lower limbs and usual gait speed were measured in a portion of older (≥60 years of age) participants (n = 1,934). The speed of sound (SOS) in the calcaneal bone was assessed via a quantitative ultrasound technique. Results In the total population, the frequency of low skeletal muscle mass linearly increased with the SAF-AGE quartiles (Q1: 14.2%, Q2: 16.1%, Q3: 21.1%, Q4: 24.8%; p < .001), and this association was independent of covariates including glycemic traits (Q4: odds ratio [OR] = 1.48, p < .001). The association between the highest SAF-AGE quartile and low skeletal muscle mass remained significant in the older subpopulation (OR = 1.85, p = .002). A similar but weak association was observed for low SOS (Q1: 8.9%, Q2: 8.3%, Q3: 10.4%, Q4: 12.2%; p < .001). Similar inverse associations were also observed with grip strength (OR = 1.98, p = .003), hip flexion strength (OR = 1.50, p = .012), and hip abduction strength (OR = 1.78, p = .001), but not with usual gait speed. Conclusion Accumulation of AGEs might be a deleterious factor for musculoskeletal properties.

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Effects of age on ventilatory threshold and peak oxygen uptake normalised for regional skeletal muscle mass in Japanese men and women aged 20–80 years

European Journal of Applied Physiology ◽

10.1007/s00421-006-0375-6 ◽

2006 ◽

Vol 99 (5) ◽

pp. 475-483 ◽

Cited By ~ 36

Author(s):

Kiyoshi Sanada ◽

Tsutomu Kuchiki ◽

Motohiko Miyachi ◽

Kelly McGrath ◽

Mitsuru Higuchi ◽

...

Keyword(s):

Skeletal Muscle ◽

Oxygen Uptake ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Ventilatory Threshold ◽

Peak Oxygen Uptake ◽

Japanese Men ◽

Men And Women

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Total And Regional Skeletal Muscle Mass In Middle-aged And Elderly Japanese Men And Women

Medicine & Science in Sports & Exercise ◽

10.1249/00005768-200505001-01574 ◽

2005 ◽

Vol 37 (Supplement) ◽

pp. S301

Author(s):

Taishi Midorikawa ◽

Takashi Abe ◽

Kiyoshi Sanada ◽

Charles F. Kearns ◽

Tetsuo Fukunaga

Keyword(s):

Skeletal Muscle ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Middle Aged ◽

Japanese Men ◽

Men And Women ◽

Elderly Japanese

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Development of prediction equations for estimating appendicular skeletal muscle mass in Japanese men and women

Journal of PHYSIOLOGICAL ANTHROPOLOGY ◽

10.1186/s40101-017-0150-x ◽

2017 ◽

Vol 36 (1) ◽

Cited By ~ 4

Author(s):

Taishi Furushima ◽

Motohiko Miyachi ◽

Motoyuki Iemitsu ◽

Haruka Murakami ◽

Hiroshi Kawano ◽

...

Keyword(s):

Skeletal Muscle ◽

Muscle Mass ◽

Skeletal Muscle Mass ◽

Prediction Equations ◽

Japanese Men ◽

Men And Women ◽

Appendicular Skeletal Muscle ◽

Appendicular Skeletal Muscle Mass

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Whole-body skeletal muscle mass is not related to glucose tolerance or insulin sensitivity in overweight and obese men and women

Applied Physiology Nutrition and Metabolism ◽

10.1139/h08-060 ◽

2008 ◽

Vol 33 (4) ◽

pp. 769-774 ◽

Cited By ~ 32

Author(s):

Jennifer L. Kuk ◽

Katherine Kilpatrick ◽

Lance E. Davidson ◽

Robert Hudson ◽

Robert Ross

Keyword(s):

Skeletal Muscle ◽

Adipose Tissue ◽

Insulin Sensitivity ◽

Glucose Tolerance ◽

Muscle Mass ◽

Visceral Adipose Tissue ◽

Skeletal Muscle Mass ◽

Whole Body ◽

Men And Women ◽

Visceral Adipose

The relationship between skeletal muscle mass, visceral adipose tissue, insulin sensitivity, and glucose tolerance was examined in 214 overweight or obese, but otherwise healthy, men (n = 98) and women (n = 116) who participated in various exercise and (or) weight-loss intervention studies. Subjects had a 75 g oral glucose tolerance test and (or) insulin sensitivity measures by a 3 h hyperinsulinemic–euglycemic clamp technique. Whole-body skeletal muscle mass and visceral adipose tissue were measured using a multi-slice magnetic resonance imaging protocol. Total body skeletal muscle mass was not associated with any measure of glucose metabolism in men or women (p > 0.10). These observations remained independent of age and total adiposity. Conversely, visceral adipose tissue was a significant predictor of various measures of glucose metabolism in both men and women with or without control for age and (or) total body fat (p < 0.05). Although skeletal muscle is a primary site for glucose uptake and deposition, these findings suggest that unlike visceral adipose tissue, whole-body skeletal muscle mass per se is not associated with either glucose tolerance or insulin sensitivity in overweight and obese men and women.

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Effect of Daily Macadamia Nut Consumption on Anthropometric Indices in Overweight and Obese Men and Women

Current Developments in Nutrition ◽

10.1093/cdn/nzaa047_009 ◽

2020 ◽

Vol 4 (Supplement_2) ◽

pp. 589-589

Author(s):

Julie Jones ◽

Sujatha Rajaram ◽

Celine Heskey ◽

Rawiwan Sirirat ◽

Abigail Clarke ◽

...

Keyword(s):

Skeletal Muscle ◽

Body Weight ◽

Waist Circumference ◽

Muscle Mass ◽

Body Fat ◽

Skeletal Muscle Mass ◽

Percent Body Fat ◽

Daily Consumption ◽

Men And Women ◽

Macadamia Nuts

Abstract Objectives We sought to assess the effect of daily consumption of macadamia nuts as 15% of calories on body weight, BMI, waist circumference, percent body fat and skeletal muscle mass in overweight/obese men and women with elevated cardiometabolic risk. Methods Utilizing a randomized crossover design, we randomized 38 subjects to consume macadamia nuts daily as 15% of calories for 8 weeks (intervention) and their usual diet for 8 weeks (control), with a 2-week washout. Three subjects dropped out early; n = 35 for analysis. Subjects were healthy men and postmenopausal women with a BMI of 25–39, a waist circumference of >101.6 cm for men and >88.9 cm for women, and one additional cardiovascular risk factor (fasting plasma glucose >100 mg/dL, triglycerides ≥150 mg/dl, total cholesterol >200 mg/dL, LDL-C > 100 mg/dL, blood pressure ≥130/85 mmHg or taking anti-hypertensive medication). Macadamia nuts were provided in pre-weighed daily portions as 15% of calories calculated using the Mifflin-St. Jeor equation. Percent body fat and skeletal muscle mass (kg) were determined by bioelectrical impedance analysis. A mixed model analysis was performed with treatment, sequence, phase, and baseline values as fixed-effect terms and subjects as a random-effects term. Results Compared to control, consumption of macadamia nuts led to a mean weight change of –348 g (84.13 vs. 83.78 kg; P = 0.15) a mean BMI change of –0.15 kg/m2 (30.61 vs. 30.47 kg/m2; P = 0.12), and a mean waist circumference change of 0.17 cm (107.41 vs. 107.58 cm; P = 0.61). Percent body fat increased by an average of 0.26% after eating nuts (42.70 vs. 42.96%; P = 0.16). Skeletal muscle mass was slightly but significantly lower after eating nuts with a mean change of –0.237 kg (26.33 vs. 26.09 kg; P = 0.017). Conclusions Daily consumption of high-fat macadamia nuts for eight weeks in overweight and obese individuals did not change anthropometrics including body weight, BMI, waist circumference, and % body fat. Skeletal muscle mass was slightly lowered but likely not clinically relevant. Funding Sources Hort Innovation, Sydney, Australia.

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