scholarly journals CRYPTIC REPEATED GENOMIC RECOMBINATION DURING SPECIATION IN GOSSYPIUM GOSSYPIOIDES

Evolution ◽  
2003 ◽  
Vol 57 (11) ◽  
pp. 2475-2489 ◽  
Author(s):  
Richard Cronn ◽  
Randall L. Small ◽  
Tamara Haselkorn ◽  
Jonathan F. Wendel
Keyword(s):  
Genomic Recombination

scholarly journals Genomic recombination in primate bocavirus: inconsistency and alternative interpretations

Virus Genes ◽  
2017 ◽  
Vol 53 (6) ◽  
pp. 774-777 ◽  
Author(s):  
Yee Ling Chong ◽  
Kar Hon Ng
Keyword(s):  
Genomic Recombination

scholarly journals Reproduction in Trypanosomatids: Past and Present

Biology ◽  
2021 ◽  
Vol 10 (6) ◽  
pp. 471
Author(s):  
Camino Gutiérrez-Corbo ◽  
Bárbara Domínguez-Asenjo ◽  
María Martínez-Valladares ◽  
Yolanda Pérez-Pertejo ◽  
Carlos García-Estrada ◽  
...  
Keyword(s):  
Low Income ◽  
Phenotypic Diversity ◽  
Natural Populations ◽  
Genetic Exchange ◽  
Health Concern ◽  
Current Debate ◽  
Naturally Occurring ◽  
Experimental Works ◽  
Genomic Recombination ◽  
The Impact

Diseases caused by trypanosomatids (Sleeping sickness, Chagas disease, and leishmaniasis) are a serious public health concern in low-income endemic countries. These diseases are produced by single-celled parasites with a diploid genome (although aneuploidy is frequent) organized in pairs of non-condensable chromosomes. To explain the way they reproduce through the analysis of natural populations, the theory of strict clonal propagation of these microorganisms was taken as a rule at the beginning of the studies, since it partially justified their genomic stability. However, numerous experimental works provide evidence of sexual reproduction, thus explaining certain naturally occurring events that link the number of meiosis per mitosis and the frequency of mating. Recent techniques have demonstrated genetic exchange between individuals of the same species under laboratory conditions, as well as the expression of meiosis specific genes. The current debate focuses on the frequency of genomic recombination events and its impact on the natural parasite population structure. This paper reviews the results and techniques used to demonstrate the existence of sex in trypanosomatids, the inheritance of kinetoplast DNA (maxi- and minicircles), the impact of genetic exchange in these parasites, and how it can contribute to the phenotypic diversity of natural populations.

scholarly journals High-frequency Alu-mediated genomic recombination/deletion within the caspase-activated DNase gene in human hepatoma

Oncogene ◽  
2005 ◽  
Vol 24 (43) ◽  
pp. 6584-6589 ◽  
Author(s):  
Sen-Yung Hsieh ◽  
Wai-Ying Chen ◽  
Ta-Sen Yeh ◽  
I-Shyan Sheen ◽  
Shiu-Feng Huang
Keyword(s):  
High Frequency ◽  
Human Hepatoma ◽  
Caspase Activated Dnase ◽  
Genomic Recombination

scholarly journals Extensive Proliferation of Transposable Elements in Heritable Bacterial Symbionts

2007 ◽  
Vol 190 (2) ◽  
pp. 777-779 ◽  
Author(s):  
Gordon R. Plague ◽  
Helen E. Dunbar ◽  
Phat L. Tran ◽  
Nancy A. Moran
Keyword(s):  
Transposable Elements ◽  
Insertion Sequence ◽  
Early Stage ◽  
Bacterial Symbionts ◽  
Is Elements ◽  
Bacterial Endosymbionts ◽  
Genomic Recombination

ABSTRACT We found that insertion sequence (IS) elements are unusually abundant in the relatively recently evolved bacterial endosymbionts of maize weevils. Because multicopy elements can facilitate genomic recombination and deletion, this IS expansion may represent an early stage in the genomic reduction that is common in most ancient endosymbionts.

scholarly journals Multiple Genomic Recombination Events in the Evolution of Saffold Cardiovirus

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74947 ◽  
Author(s):  
Lili Ren ◽  
Yan Xiao ◽  
Jianguo Li ◽  
Lan Chen ◽  
Jing Zhang ◽  
...  
Keyword(s):  
Genomic Recombination

scholarly journals Pervasive Genomic Recombination of HIV-1in Vivo

Genetics ◽  
2004 ◽  
Vol 167 (4) ◽  
pp. 1573-1583 ◽  
Author(s):  
Daniel Shriner ◽  
Allen G. Rodrigo ◽  
David C. Nickle ◽  
James I. Mullins
Keyword(s):  
Genomic Recombination

scholarly journals bcr Rearrangement without juxtaposition of c-abl in chronic myelocytic leukemia.

1985 ◽  
Vol 162 (6) ◽  
pp. 2175-2179 ◽  
Author(s):  
C R Bartram
Keyword(s):  
Blot Analysis ◽  
Southern Blot Analysis ◽  
Gene Rearrangement ◽  
Northern Blot Analysis ◽  
Philadelphia Chromosome ◽  
Leukemic Cells ◽  
Chronic Myelocytic Leukemia ◽  
Myelocytic Leukemia ◽  
Genomic Recombination

Southern blot analysis detected a bcr gene rearrangement within leukemic cells of a Philadelphia chromosome-negative chronic myelocytic leukemia (CML) patient that led to transcription of a novel 7.3 kb bcr RNA species. Participation of the c-abl oncogene in this genomic recombination could be ruled out by in situ hybridization studies and Northern blot analysis.

scholarly journals Ancestral chytrid pathogen remains hypervirulent following its long coevolution with amphibian hosts

2019 ◽  
Vol 286 (1904) ◽  
pp. 20190833 ◽  
Author(s):  
Minjie Fu ◽  
Bruce Waldman
Keyword(s):  
Batrachochytrium Dendrobatidis ◽  
Population Declines ◽  
Amphibian Species ◽  
South Korean ◽  
Global Pandemic ◽  
Litoria Caerulea ◽  
Experimental Treatments ◽  
Amphibian Chytrid Fungus ◽  
Genomic Recombination ◽  
Blank Solution

Many amphibian species around the world, except in Asia, suffer morbidity and mortality when infected by the emerging infectious pathogen Batrachochytrium dendrobatidis (Bd). A lineage of the amphibian chytrid fungus isolated from South Korean amphibians (BdAsia-1) is evolutionarily basal to recombinant global pandemic lineages (BdGPL) associated with worldwide amphibian population declines. In Asia, the Bd pathogen and its amphibian hosts have coevolved over 100 years or more. Thus, resilience of Asian amphibian populations to infection might result from attenuated virulence of endemic Bd lineages, evolved immunity to the pathogen or both. We compared susceptibilities of an Australasian amphibian, Litoria caerulea , known to lack resistance to BdGPL, with those of three Korean species, Bufo gargarizans , Bombina orientalis and Hyla japonica , after inoculation with BdAsia-1, BdGPL or a blank solution. Subjects became infected in all experimental treatments but Korean species rapidly cleared themselves of infection, regardless of Bd lineage. They survived with no apparent secondary effects. By contrast, L. caerulea , after infection by either BdAsia-1 or BdGPL, suffered deteriorating body condition and carried progressively higher Bd loads over time. Subsequently, most subjects died. Comparing their effects on L. caerulea , BdAsia-1 induced more rapid disease progression than BdGPL. The results suggest that genomic recombination with other lineages was not necessary for the ancestral Bd lineage to evolve hypervirulence over its long period of coevolution with amphibian hosts. The pathogen's virulence may have driven strong selection for immune responses in endemic Asian amphibian host species.

scholarly journals Complete genome characterisation of a novel coronavirus associated with severe human respiratory disease in Wuhan, China

2020 ◽  
Author(s):  
Fan Wu ◽  
Su Zhao ◽  
Bin Yu ◽  
Yan-Mei Chen ◽  
Wen Wang ◽  
...  
Keyword(s):  
Respiratory Disease ◽  
Rna Virus ◽  
Research Effort ◽  
Severe Disease ◽  
Emerging Infectious Diseases ◽  
Lavage Fluid ◽  
Control And Prevention ◽  
Food Market ◽  
Novel Coronavirus ◽  
Genomic Recombination

Emerging and re-emerging infectious diseases, such as SARS, MERS, Zika and highly pathogenic influenza present a major threat to public health1–3. Despite intense research effort, how, when and where novel diseases appear are still the source of considerable uncertainly. A severe respiratory disease was recently reported in the city of Wuhan, Hubei province, China. At the time of writing, at least 62 suspected cases have been reported since the first patient was hospitalized on December 12nd 2019. Epidemiological investigation by the local Center for Disease Control and Prevention (CDC) suggested that the outbreak was associated with a sea food market in Wuhan. We studied seven patients who were workers at the market, and collected bronchoalveolar lavage fluid (BALF) from one patient who exhibited a severe respiratory syndrome including fever, dizziness and cough, and who was admitted to Wuhan Central Hospital on December 26th 2019. Next generation metagenomic RNA sequencing4 identified a novel RNA virus from the family Coronaviridae designed WH-Human-1 coronavirus (WHCV).Phylogenetic analysis of the complete viral genome (29,903 nucleotides) revealed that WHCV was most closely related (89.1% nucleotide similarity similarity) to a group of Severe Acute Respiratory Syndrome (SARS)-like coronaviruses (genus Betacoronavirus, subgenus Sarbecovirus) previously sampled from bats in China and that have a history of genomic recombination. This outbreak highlights the ongoing capacity of viral spill-over from animals to cause severe disease in humans.

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