Distribution of High Density Lipoprotein Cholesterol According to Relative Body Weight, Cigarette Smoking and Leisure Time Physical Activity

Aims Physical activity has consistently been shown to improve cardiovascular health and high-density lipoprotein-cholesterol levels. However, only small and heterogeneous studies have investigated the effect of exercise on high-density lipoprotein functions. Our aim is to evaluate, in the largest observational study to date, the association between leisure time physical activity and a range of high-density lipoprotein functional traits. Methods The study sample consisted of 296 Spanish adults at high cardiovascular risk. Usual leisure time physical activity and eight measures of high-density lipoprotein functionality were averaged over two measurements, one year apart. Multivariable linear regression models were used to explore the association between leisure time physical activity (exposure) and each high-density lipoprotein functional trait (outcome), adjusted for cardiovascular risk factors. Results Higher levels of leisure time physical activity were positively and linearly associated with average levels over one year of plasma high-density lipoprotein-cholesterol and apolipoprotein A-I, paraoxonase-1 antioxidant activity, high-density lipoprotein capacity to esterify cholesterol and cholesterol efflux capacity in individuals free of type 2 diabetes only. The increased cholesterol esterification index with increasing leisure time physical activity reached a plateau at around 300 metabolic equivalents.min/day. In individuals with diabetes, the relationship with cholesteryl ester transfer protein followed a U-shape, with a decreased cholesteryl ester transfer protein activity from 0 to 300 metabolic equivalents.min/day, but increasing from there onwards. Increasing levels of leisure time physical activity were associated with poorer high-density lipoprotein vasodilatory capacity. Conclusions In a high cardiovascular risk population, leisure time physical activity was associated not only with greater circulating levels of high-density lipoprotein-cholesterol, but also with better markers of high-density lipoprotein functionality, namely cholesterol efflux capacity, the capacity of high-density lipoprotein to esterify cholesterol and paraoxonase-1 antioxidant activity in individuals free of diabetes and lower cholesteryl ester transfer protein activity in individuals with type 2 diabetes.

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A Biochemical Study Of High-Density Lipoprotein Cholesterol (Hdl-C) Changes In Middle Aged Common People With Different Lifestyle

Bangladesh Journal of Medical Science ◽

10.3329/bjms.v16i2.25061 ◽

2017 ◽

Vol 16 (2) ◽

pp. 289-294

Author(s):

Suresh Kanna ◽

Premila Thamizhvanan ◽

Jaya Bharathi

Keyword(s):

Physical Activity ◽

Body Weight ◽

Young Adult ◽

High Density Lipoprotein ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

Hdl Cholesterol ◽

Lifestyle Factors ◽

High Density ◽

Lipoprotein Cholesterol

Background and rationale: HDL cholesterol is one of the 5 major groups of lipoproteins cholesterol, which enable lipids like cholesterol and TG to be transported within the water based blood stream. In healthy persons, about thirty percent of blood cholesterol is carried by HDL cholesterol. HDL-C is a potent predictor of coronary heart disease. Genetic as well as environmental factors including lifestyle factors play a role as determinants of its level in the blood. To examine the effects of certain lifestyle factors on serum level of high density lipoprotein cholesterol in young adult people HDL cholesterol seems to protect against CVD which increases the risk for heart disease.Subjects and methods: Three hundred and twenty five young adult subjects of both sexes aged 18-45 years asymptomatic for cardiovascular diseases were interviewed according to special questionnaire including information on lifestyle habits. Physical examination was done, height, body weight, and blood pressure measurements were performed. Blood analysis to determine the blood level of high density lipoprotein cholesterol was done after 12 hours fasting.Results and conclusion: Smoking and obesity were the most significant risk factors associated with a decreased level of high density lipoprotein cholesterol. The level of HDL-C was 50.5±11.5 mg/dl in smokers compared with 57.7±12.5 mg/dl in nonsmokers. Its level was 48.5 ±8.5 mg/dl in obese individuals compared to 57.5±11.7mg/dl in normal body weight subjects. Physical activity was not significantly associated with low level of HDL-C analysis, but it was found to be significantly associated with its level by the multiple regression analysis. High-density lipoprotein cholesterol level was a function of many factors, some of them were lifestyle related such as smoking, physical activity, and obesity. Therefore, efforts to encourage more physical activity, quitting smoking, consuming low fat diet, and keeping ideal body weight are recommended.Bangladesh Journal of Medical Science Vol.16(2) 2017 p.289-294

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Physical activity modulates the combined effect of a common variant of the lipoprotein lipase gene and smoking on serum triglyceride levels and high-density lipoprotein cholesterol in men

Human Genetics ◽

10.1007/s004390100584 ◽

2001 ◽

Vol 109 (4) ◽

pp. 385-392 ◽

Cited By ~ 39

Author(s):

Mariano Sentí ◽

Roberto Elosua ◽

Marta Tomás ◽

Joan Sala ◽

Rafael Masiá ◽

...

Keyword(s):

Physical Activity ◽

High Density Lipoprotein ◽

Lipoprotein Lipase ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

Serum Triglyceride ◽

Combined Effect ◽

Common Variant ◽

Lipoprotein Cholesterol ◽

Lipase Gene

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Association of Physical Activity and Cardiometabolic Risk in Children 3–12 Years

Journal of Physical Activity and Health ◽

10.1123/jpah.2020-0028 ◽

2020 ◽

Vol 17 (8) ◽

pp. 800-806

Author(s):

Leigh M. Vanderloo ◽

Jonathan L. Maguire ◽

David W. H. Dai ◽

Patricia C. Parkin ◽

Cornelia M. Borkhoff ◽

...

Keyword(s):

Physical Activity ◽

Blood Pressure ◽

High Density Lipoprotein ◽

Systolic Blood Pressure ◽

High Density Lipoprotein Cholesterol ◽

Density Lipoprotein ◽

High Density ◽

Lipoprotein Cholesterol ◽

Height Ratio ◽

Waist To Height Ratio

Background: This study aimed to examine the association between physical activity (PA) and a total cardio metabolic risk (CMR) score in children aged 3–12 years. Secondary objectives were to examine the association between PA and individual CMR factors. Methods: A longitudinal study with repeated measures was conducted with participants from a large primary care practice-based research network in Toronto, Canada. Mixed effects models were used to examine the relationship between parent-reported physical activity and outcome variables (total CMR score, triglycerides, glucose, high-density lipoprotein cholesterol, systolic blood pressure, waist circumference, weight-to-height ratio, and non-high-density lipoprotein cholesterol). Results: Data from 1885 children (6.06 y, 54.4% male) with multiple visits (n = 2670) were included in the analyses. For every unit increase of 60 minutes of PA, there was no evidence of an association with total CMR score (adjusted: −0.02 [−0.014 to 0.004], P = .11]. For the individual CMR components, there was evidence of a weak association between PA and systolic blood pressure (−0.01 [−0.03 to −0.01], P < .001) and waist-to-height ratio (−0.81 [−1.62 to −0.003], P < .001). Conclusion: Parent-reported PA among children aged 3–12 years was not statistically associated with total CMR, but was weakly associated with systolic blood pressure and waist-to-height ratio.

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