Anti-cancer effect of adenovirus p53 on human cervical cancer cell growth in vitro and in vivo

2004 ◽  
Vol 14 (2) ◽  
pp. 322-332 ◽  
Author(s):  
W. S. Ahn ◽  
S. M. Bae ◽  
J. M. Lee ◽  
S. E. Namkoong ◽  
J. Y. Yoo ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Anti Cancer ◽  
Human Cervical Cancer Cell ◽  
Human Cervical Cancer

scholarly journals HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Lei ◽  
Wen-Ting Yang ◽  
Peng-Sheng Zheng
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Tumor Formation ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Bioinformatics Analyses

AbstractHomeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and tumorigenesis. However, its biological function and exact mechanism in cervical cancer remain unknown. Here, we found that HOXB4 was markedly downregulated in cervical cancer. We demonstrated that HOXB4 obviously suppressed cervical cancer cell proliferation and tumorigenic potential in nude mice. Additionally, HOXB4-induced cell cycle arrest at the transition from the G0/G1 phase to the S phase. Conversely, loss of HOXB4 promoted cervical cancer cell growth both in vitro and in vivo. Bioinformatics analyses and mechanistic studies revealed that HOXB4 inhibited the activity of the Wnt/β-catenin signaling pathway by direct transcriptional repression of β-catenin. Furthermore, β-catenin re-expression rescued HOXB4-induced cervical cancer cell defects. Taken together, these findings suggested that HOXB4 directly transcriptional repressed β-catenin and subsequently inactivated the Wnt/β-catenin signaling pathway, leading to significant inhibition of cervical cancer cell growth and tumor formation.

scholarly journals Fibulin-3 knockdown inhibits cervical cancer cell growth and metastasis in vitro and in vivo

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Juan Li ◽  
Chen Qi ◽  
Xia Liu ◽  
Changzhong Li ◽  
Jie Chen ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Knockdown of hTERT by siRNA inhibits cervical cancer cell growth in vitro and in vivo

2014 ◽  
Vol 45 (3) ◽  
pp. 1216-1224 ◽  
Author(s):  
YING-AI SHI ◽  
QIANG ZHAO ◽  
LI-HONG ZHANG ◽  
WEI DU ◽  
XUE-YAO WANG ◽  
...  
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Inhibition of cervical cancer cell growth in vitro and in vivo with dual shRNAs

2010 ◽  
Vol 18 (3) ◽  
pp. 219-227 ◽  
Author(s):  
W Gu ◽  
E Payne ◽  
S Sun ◽  
M Burgess ◽  
N A J McMillan
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth
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