scholarly journals Clinical trial: effect of active lactic acid bacteria on mucosal barrier function in patients with diarrhoea-predominant irritable bowel syndrome

2008 ◽  
Vol 28 (8) ◽  
pp. 994-1002 ◽  
Author(s):  
J. ZENG ◽  
Y.-Q. LI ◽  
X.-L. ZUO ◽  
Y.-B. ZHEN ◽  
J. YANG ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Irritable Bowel Syndrome ◽  
Lactic Acid ◽  
Lactic Acid Bacteria ◽  
Barrier Function ◽  
Mucosal Barrier ◽  
Trial Effect ◽  
Mucosal Barrier Function ◽  
Irritable Bowel

scholarly journals Unique strain of Bifidobacterium longum and its efficacy in irritable bowel syndrome

2021 ◽  
pp. 144-150
Author(s):  
E. Yu. Plotnikova
Keyword(s):  
Irritable Bowel Syndrome ◽  
Barrier Function ◽  
Adult Population ◽  
Bifidobacterium Longum ◽  
Intestinal Flora ◽  
Visceral Hypersensitivity ◽  
Mucosal Barrier ◽  
Abdominal Symptoms ◽  
Mucosal Barrier Function ◽  
Irritable Bowel

Irritable bowel syndrome (IBS) is one of the most prevalent gastrointestinal disorders affecting between 5 and 15% of the general adult population worldwide. Over the course of many years altered intestinal motility, visceral hypersensitivity, immune changes and, as it has recently been found, impaired epithelial barrier function were meant to explain the origin of symptoms in the IBS. We have come to realize now that the IBS warrants serious clinical and scientific study. Not that long ago, the connections between the gut and the brain have been expanded to include a new entrant, the microbiota, resulting in the creation of a new concept of a microbiota-gut-brain axis.Microbiota is a risk factor for the irritable bowel syndrome. Probiotics are defined as live microorganisms, which can alter the intestinal flora and regulate intestinal functions such as reduction of visceral hypersensitivity, improvement of mucosal barrier function, modulate immune responses and chronic inflammation, affect the central nervous system, gastrointestinal motility, etc. The correctness of this approach is confirmed by several studies of the probiotic Bifidobacterium longum subsp. longum 35624, which is widely used in the treatment of symptoms of irritable bowel syndrome. The dietary supplement Bifidobacterium longum subsp. longum 35624 contains 1 × 109 colony-forming units, which provides a clinically effective level of these beneficial bacteria. Bifidobacterium longum subsp. longum 35624 also reduces inflammation in the gastrointestinal tract and has positive results in reducing abdominal symptoms (e.g. abdominal pain / discomfort and bloating) associated with the irritable bowel syndrome and other conditions. 

scholarly journals PO-105 Exercise regulates HMGB1 / TLR4 / NF- κ B pathway by H2S to improve OJ intestinal injury

2018 ◽  
Vol 1 (4) ◽  
Author(s):  
Changfeng Shao ◽  
Jiaqin Chen ◽  
Wei Chen ◽  
Qi Peng ◽  
Di Li ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Obstructive Jaundice ◽  
Aerobic Exercise ◽  
Intestinal Mucosa ◽  
Barrier Function ◽  
Immunohistochemical Staining ◽  
Mucosal Barrier ◽  
Intestinal Mucosal Barrier ◽  
Qrt Pcr ◽  
Mucosal Barrier Function

Objective To study the effect of aerobic exercise on the damage of intestinal mucosal barrier function caused by obstructive jaundice（OJ）and to explore its mechanism of action. Methods  50 male KM mice were randomly divided into 5 groups: sham operation group (S), model group (M), exercise group (TM), DL-Propargylglycine + exercise (PT) group and sodium hydrosulfide + exercise (NT) group.In addition to the S group which are in the common bile duct to the abdominal wall hanging 48 hours to build mouse obstructive jaundice model. In the PT group, PAG (40 mg/kg) was intraperitoneally injected 7 days after surgery; NaHS (50 μmol/kg) was intraperitoneally injected in the NT group 7 days after surgery; TM group, NT group and PT group were graded at 0%, and the speed was 10m/min no weight training (30min/day).After 6 weeks, HE staining was used to observe the morphological changes of the intestinal mucosa.Biochemical analysis was used to detect the concentration of hydrogen sulfide (H2S) in blood and ileum, and total bilirubin (TBIL), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) Liver function, diamine oxidase (DAO), D-lactic acid intestinal barrier function biochemical index; qRT-PCR and immunohistochemical staining were used to observe the expression changes of H2S-mediated related channel mRNA and protein（HMGB1, TLR4 and NF-Kbp6）in intestinal tissues. Results HE staining showed that the intestinal mucosa of group M was atrophied and the villus was broken.Compared with M group, the intestinal mucosa arrangement in TM group was relatively regular. Compared with TM group, intestinal mucosa atrophy in PT group, fluff hair loss, sparseness and disorder, partial mucosa The layer was separated from the lamina propria and the gland was severely damaged. The intestinal mucosa of the NT group was relatively regular, and the changes of intestinal mucosa atrophy were restored. Serum test results showed that H2S levels were higher in the TM group than in the M group; compared with the TM group, the PT group decreased and the NT group increased. DAO level: The TM group was lower than the M group; compared with the TM group, the PT group was elevated and the NT group was decreased.  Changes in serum D-lactic acid levels were similar to DAO. The results of qRT-PCR and immunohistochemical staining showed that the expressions of HMGB1, TLR4 and NF-Kbp6 mRNA and protein in the intestinal tissues of mice in TM group were significantly lower than those in M group and PT group, and the mRNA and protein expression levels in NT group were the lowest. Conclusions Aerobic exercise inhibits the HMGB1 / TLR4 / NF-κB signaling pathway through the H2S / CSE system, thereby exerting a protective effect on the intestinal mucosal barrier.

scholarly journals A REVIEW ON APPLICATIONS OF PROBIOTICS IN HUMAN HEALTH AND DISEASE

2019 ◽  
Vol 8 (1) ◽  
Author(s):  
Yasaman Pakdaman
Keyword(s):  
Lactic Acid ◽  
Immune System ◽  
Lactic Acid Bacteria ◽  
Human Health ◽  
Bifidobacterium Longum ◽  
New Drugs ◽  
Mucosal Barrier ◽  
Marine Microorganisms ◽  
Mucosal Barrier Function ◽  
Antibiotic Associated Diarrhea

The emergence of resistance and tolerance to the existing drugs has created a decreased efficacy of these drugs in use. Along with the advancement in other fields of medicine, the problem of resistance has been tried to be overcome by increasing the drug delivery to the target site by the use of polymers or through nanotechnology, synthesis of new drugs, either by the use of proteomics or synthesis from lactic acid bacteria, or marine microorganisms. Recent research has revealed a potential therapeutic role for the manipulation of the microbiota in the maintenance of human health and treatment of various mucosal disorders. Probiotic microorganisms can shape the immune system both at the local and systemic level which will allow future probiotics as treatments for many diseases. The benefits include either a shortened duration of infections or decreased susceptibility to pathogens.                    Probiotic bacteria have multiple and various influences onthe host. Different organisms can influence the intestinal luminal environment, epithelial and mucosal barrier function, and the mucosal immune system. The numerous cell types affected by probiotics involve epithelial cells, dendritic cells, monocytes/macrophages, B cells, T cells. Probiotics do not always colonize the intestinal tract to exert their effects. Some probiotics like Bifidobacterium longum become part of the human intestinal microflora, whereas others like Lactobacillus casei indirectly exert their effects in a transient manner as they pass through by remodeling or influencing the existing microbial community.          Probiotics seem to have promising role in shortening duration of infections or decreasing susceptibility to the pathogens. Incorporation of probiotics in nutrition as a means of derivation of health benefits. The best documented effects include bowel disorders such as lactose intolerance, antibiotic-associated diarrhea and infectious diarrhea, emerging evidence accumulates concerning their potential role in various other conditions. In the same time as relevant consumer awareness grows, such products are becoming increasingly popular and tend to represent one of the largest functional food markets. Key words: probiotics, Antibiotic associated diarrhea, microorganisms, Antibiotic resistance, Lactic acid bacteria.

Lacto-fermented sauerkraut improves symptoms in IBS patients independent of product pasteurisation – a pilot study

2018 ◽  
Vol 9 (10) ◽  
pp. 5323-5335 ◽  
Author(s):  
Elsa Sandberg Nielsen ◽  
Eirik Garnås ◽  
Kathrine Juul Jensen ◽  
Lars Hestbjerg Hansen ◽  
Peder Sandvold Olsen ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Lactic Acid ◽  
Pilot Study ◽  
Lactic Acid Bacteria ◽  
Irritable Bowel

Lacto-fermented sauerkraut contains a natural variety of lactic acid bacteria (LAB) and has not previously been studied in the treatment of irritable bowel syndrome (IBS).

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