Six Area, Six Sign Atopic Dermatitis (SASSAD) severity score: a simple system for monitoring disease activity in atopic dermatitis*

1996 ◽  
Vol 135 ◽  
pp. 25-30 ◽  
Author(s):  
J. BERTH-JONES
Keyword(s):  
Atopic Dermatitis ◽  
Disease Activity ◽  
Severity Score ◽  
Simple System

scholarly journals Correlation between serum carbohydrate antigen 19-9 levels and computed tomography severity score in patients with nontuberculous mycobacterial pulmonary disease

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kangjoon Kim ◽  
Seung Hyun Yong ◽  
Su Hwan Lee ◽  
Sang Hoon Lee ◽  
Ah Young Leem ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Disease Activity ◽  
Pulmonary Disease ◽  
Severity Score ◽  
Partial Correlation ◽  
Elevated Serum ◽  
Carbohydrate Antigen ◽  
Chest Ct ◽  
Clinical Biomarker ◽  
Serum Carbohydrate Antigen

AbstractThere is no validated clinical biomarker for disease severity or treatment response for nontuberculous mycobacterial pulmonary disease (NTM-PD). We investigated the correlation between elevated serum carbohydrate antigen (CA) 19-9 levels and NTM-PD disease activity, defined using an imaging severity score based on chest computed tomography (CT). We retrospectively examined 79 patients with NTM-PD who underwent serum CA19-9 level assessments and chest CT less than 1 month apart. NTM-PD severity was rated using a CT-based scoring system. The correlation between the CT score and serum CA19-9 levels was evaluated. Chest CT revealed nodular bronchiectasis without cavitation in most patients (78.5%). Serum CA19-9 levels were elevated in 19 (24%) patients. Serum CA19-9 levels were positively correlated with the total CT score and bronchiectasis, bronchiolitis, cavity, and consolidation subscores. Partial correlation analysis revealed a significant positive correlation between serum CA19-9 levels and CT scores for total score and bronchiectasis, bronchiolitis, cavitation, and consolidation subscores after controlling for age, sex, and BMI. Serum CA19-9 levels were positively correlated with the CT severity score for NTM-PD. Serum CA19-9 may be useful in evaluating disease activity or therapeutic response in patients with NTM-PD.

Nerve growth factor and substance P are useful plasma markers of disease activity in atopic dermatitis

2002 ◽  
Vol 147 (1) ◽  
pp. 71-79 ◽  
Author(s):  
M. Toyoda ◽  
M. Nakamura ◽  
T. Makino ◽  
T. Hino ◽  
M. Kagoura ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Nerve Growth Factor ◽  
Growth Factor ◽  
Substance P ◽  
Disease Activity ◽  
Nerve Growth ◽  
Plasma Markers

scholarly journals Topical Application of Doxycycline Inhibits Th2 Cell Development Mediated by Langerhans Cells and Exerts a Therapeutic Effect on Atopic Dermatitis

2020 ◽  
Vol 23 ◽  
pp. 86-99 ◽  
Author(s):  
Katsuhiko Matsui ◽  
Yuki Nojima ◽  
Yuka Kajiwara ◽  
Kana Busujima ◽  
Yuki Mori
Keyword(s):  
Atopic Dermatitis ◽  
Lymph Nodes ◽  
Topical Application ◽  
Severity Score ◽  
Langerhans Cells ◽  
Skin Lesions ◽  
Cell Development ◽  
Th2 Cells ◽  
Th2 Cytokines ◽  
Th2 Cell

Background: Langerhans cells (LCs) polarize the immune milieu towards a T helper type (Th) 1 or Th2 immune response. We investigated the effects of selected tetracyclines on Th cells development mediated by LCs, and their implications for the treatment of atopic dermatitis (AD). Methods: Mice were primed with ovalbumin (OVA) peptide-pulsed LCs, which had been treated with each antibiotic, via the hind footpad. After 5 days, the Th1/Th2 cytokine response in the popliteal lymph nodes was investigated by enzyme-linked immunosorbent assay. The expression of cell surface molecules on LCs was investigated using reverse transcriptase polymerase chain reaction. The therapeutic effects of a selected antibiotic on AD-like skin lesions of NC/Nga mice were assessed in terms of the skin severity score, histological changes in the lesioned skin, the serum level of total IgE, and expression of Th1/Th2 cytokines in lymph nodes and skin lesions. Results: Antibiotic-treated, OVA peptide-pulsed LCs inhibited development of Th2 cells but not Th1 cells. This was accompanied by suppression of T-cell immunoglobulin and mucin domain-containing protein (TIM)-4 expression in LCs. Doxycycline had the greatest activity against Staphylococcus aureus strains isolated from skin lesions of patients with AD, and a strong inhibitory effect on Th2 cell development. Doxycycline suppressed the increase in the skin severity score during the acute phase in NC/Nga mice similar to betamethasone. This suppressive effect was associated with a decrease in the serum IgE level and production of Th2 cytokines in auricular lymph node cells and skin lesions. Conclusion: Topical application of doxycycline to AD lesions would act on both superficial S. aureus colonization and epidermal LCs, thus possibly inhibiting the development of Th2 cells in vivo, with benefits for control of acute inflammation in AD.

Cytok1ne Dysregulation in Children with Atopic Dermatitis: Correlation with Disease Activity

1996 ◽  
Vol 9 (2) ◽  
pp. 62-62
Author(s):  
D. Maccarone ◽  
D. Piancatelli ◽  
M.R. Della Penna ◽  
A.M. Bianchi ◽  
P. Sebastiani ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Activity

scholarly journals Eosinophil hypersegmentation is a possible marker to monitor the disease activity of atopic dermatitis

2001 ◽  
Vol 50 (4) ◽  
pp. 325-330 ◽  
Author(s):  
Akemi Yamamoto ◽  
Takatsugu Kojima ◽  
Takao Aoki ◽  
Misa Sasai ◽  
Shoichiro Taniuchi ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Disease Activity

scholarly journals Inhibitory Effect ofNelumbo nucifera(Gaertn.) on the Development of Atopic Dermatitis-Like Skin Lesions in NC/Nga Mice

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Rajendra Karki ◽  
Myung-A Jung ◽  
Keuk-Jun Kim ◽  
Dong-Wook Kim
Keyword(s):  
Atopic Dermatitis ◽  
Severity Score ◽  
Histopathological Examination ◽  
Skin Lesions ◽  
Transepidermal Water Loss ◽  
Inhibitory Effect ◽  
Clinical Severity ◽  
Inflammatory Skin Disease ◽  
Level Measurement ◽  
Different Doses

Atopic dermatitis (AD) is a chronic inflammatory skin disease which has a complex etiology that encompasses immunologic responses. The study was carried out to examine the effect ofNelumbo nucifera(Gaertn.) leaf (NL) on the AD-like skin lesion induced by repeated epicutaneous application of 2,4-dinitrochlorobenzene (DNCB) on the dorsal skin of NC/Nga mice. Three different doses of NL (5, 25, and 50 mg/mice/day) were administered orally from the day of sensitization with DNCB for 4 weeks. The efficacy of NL was judged by histopathological examination, blood IgE level, measurement of transepidermal water loss (TEWL), scratching behavior, and skin severity score. NL resulted in the suppression of clinical severity score, TEWL, scratching behavior, and blood IgE level. Histopathologic analyses revealed that thickening of the epidermis and mast cell degranulation was significantly reduced in NL group. These results suggest that NL may be a useful natural resource for the management of AD.

Expansion of FOXP3-positive CD4+CD25+ T cells associated with disease activity in atopic dermatitis

2009 ◽  
Vol 103 (2) ◽  
pp. 160-165 ◽  
Author(s):  
Yasunori Ito ◽  
Yuichi Adachi ◽  
Teruhiko Makino ◽  
Hiroyuki Higashiyama ◽  
Tatsuya Fuchizawa ◽  
...  
Keyword(s):  
T Cells ◽  
Atopic Dermatitis ◽  
Disease Activity
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