Nickel allergy: relationship between patch test and repeated open application test thresholds

Background. Xiaotong Tiegao (XTT) is an ancient topical Tibetan medicine plaster which is widely used in China. Irritant contact dermatitis (ICD) caused by XTT is very common. It is still unclear why some people are more prone to develop ICD. The aim of this study is to study the baseline skin biophysical parameters and patch test results in individuals predisposing to XTT induced ICD. Methods. During a four-month period, 149 healthy volunteers with ICD and 50 volunteers without ICD after applying XTT were recruited. The skin biophysical parameters were measured, and contact allergy to 20 common allergens was patch tested, at two weeks after the ICD was recovered. Results. There were no significant differences in age and sex between ICD and control groups. It was found that skin median melanin value (176.50 vs 189.50, P < 0.05, Mann-Whitney U-test) and erythema value (319.90 ± 70.49 vs 347.93 ± 84.55, P < 0.05, Independent-Samples T test) were much lower in ICD than control group. Overall patch test results were not different, but the positivity rate of nickel sulfate (15.44% vs 4.00%, P < 0.05, Fisher’s exact test) was significantly higher in ICD group. Conclusions. In conclusion, people with nickel allergy, lower values of skin melanin, and erythema are predisposing to develop ICD.

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Nickel allergy - prevalence in a population of Swedish youths from patch test and questionnaire data

Contact Dermatitis ◽

10.1111/j.1600-0536.2007.01257.x ◽

2007 ◽

Vol 58 (2) ◽

pp. 80-87 ◽

Cited By ~ 33

Author(s):

Ronny Fors ◽

Maurits Persson ◽

Erik Bergström ◽

Hans Stenlund ◽

Birgitta Stymne ◽

...

Keyword(s):

Patch Test ◽

Questionnaire Data ◽

Nickel Allergy ◽

Allergy Prevalence

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Correlation of patch test with repeated open application test in patients with suspected hair-dye dermatitis

Indian Journal of Dermatology Venereology and Leprology ◽

10.4103/ijdvl.ijdvl_691_19 ◽

2020 ◽

Vol 86 (6) ◽

pp. 733

Author(s):

Sushruta Kathuria ◽

Ankita Khambra ◽

V Ramesh

Keyword(s):

Patch Test ◽

Hair Dye ◽

Open Application

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Positive Occluded Patch Test in the Face of Negative Repeat Open Application Test

Dermatitis ◽

10.1097/der.0000000000000457 ◽

2019 ◽

Vol 30 (2) ◽

pp. 178

Keyword(s):

Patch Test ◽

The Face ◽

Open Application

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Correlations of patch test reactivity and the repeated open application test (ROAT)/provocative use test (PUT)

Food and Chemical Toxicology ◽

10.1016/j.fct.2004.05.009 ◽

2004 ◽

Vol 42 (11) ◽

pp. 1719-1725 ◽

Cited By ~ 20

Author(s):

Clarissa D. Villarama ◽

Howard I. Maibach

Keyword(s):

Patch Test ◽

Open Application

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Nickel allergy in lipid transfer protein sensitized patients: Prevalence and clinical features

International Journal of Immunopathology and Pharmacology ◽

10.1177/2058738420974895 ◽

2020 ◽

Vol 34 ◽

pp. 205873842097489

Author(s):

Angela Rizzi ◽

Raffaella Chini ◽

Riccardo Inchingolo ◽

Valentina Carusi ◽

Franco Pandolfi ◽

...

Keyword(s):

Patch Test ◽

Clinical Features ◽

Lipid Transfer Protein ◽

Nickel Sulfate ◽

Specific Ige ◽

Lipid Transfer ◽

Nickel Allergy ◽

Transfer Protein ◽

Mediterranean Countries ◽

Allergic Contact

Nickel (Ni), the main responsible for allergic contact dermatitis worldwide, is also involved in systemic condition called “Systemic Nickel Sulfate Allergy Syndrome (SNAS).” Likewise, IgE-mediated reactivity to Lipid Transfer Protein (LTP) represents the main cause of primary food allergy in adults of Mediterranean countries. We evaluated the prevalence of SNAS in LTP allergic patients and investigated patients’ clinical features with double sensitization (LTP and Ni). A retrospective, single-center, observational study was conducted performing a complete allergological work-up including: (1) skin prick tests; (2) serum specific IgE for plant food allergens and rPru p3 (LTP); (3) patch test with 5% Ni sulfate in petrolatum. We enrolled 140 LTP allergic patients of which 36 patients (25.7% of sample) showed additional positivity to Ni patch test. Patients with double sensitization were more frequently females and reported fewer cutaneous symptoms. Higher values of sIgE for peach, apple, peanut, walnut, grain, corn, and garlic were found in LTP allergic patients, while higher values for hazelnut in the other subgroup. The prevalence of SNAS in the LTP allergic population is clinically relevant. Moreover, the clinical and immunological profiles of patients with double sensitization were different from patients monosensitized to LTP.

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