scholarly journals Increased expression and secretion of interleukin-6 in human parvovirus B19 non-structural protein (NS1) transfected COS-7 epithelial cells

2006 ◽  
Vol 144 (1) ◽  
pp. 152-157 ◽  
Author(s):  
T.-C. Hsu ◽  
B.-S. Tzang ◽  
C.-N. Huang ◽  
Y.-J. Lee ◽  
G.-Y. Liu ◽  
...  
1996 ◽  
Vol 70 (12) ◽  
pp. 8485-8491 ◽  
Author(s):  
S Moffatt ◽  
N Tanaka ◽  
K Tada ◽  
M Nose ◽  
M Nakamura ◽  
...  

Virology ◽  
2014 ◽  
Vol 449 ◽  
pp. 297-303 ◽  
Author(s):  
Sunil Kumar Tewary ◽  
Haiyan Zhao ◽  
Xuefeng Deng ◽  
Jianming Qiu ◽  
Liang Tang

1997 ◽  
Vol 78 (1) ◽  
pp. 215-219 ◽  
Author(s):  
M Leruez-Ville ◽  
U Hazan ◽  
I Vassias ◽  
C Pallier ◽  
F Morinet ◽  
...  

2002 ◽  
Vol 83 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Hiroshi Chisaka ◽  
Eiji Morita ◽  
Kazuko Murata ◽  
Naoto Ishii ◽  
Nobuo Yaegashi ◽  
...  

Human parvovirus B19 (B19) infection during pregnancy is associated with the adverse foetal outcome known as non-immune hydrops fetalis (NIHF). Although B19 is known to infect erythroid-lineage cells in vivo as well as in vitro, the mechanism leading to the occurrence of NIHF is not clear. To investigate the possible involvement of the B19 non-structural protein NS1 in NIHF, three independent lines of transgenic mice were generated that expressed NS1 under the control of the Cre-loxP system and the GATA1 promoter. Two of the three lines expressed NS1 in erythroid-lineage cells. Most of the transgenic mice died at the embryonic stage, some of which developed hydropic changes caused by severe anaemia at embryonic day 15·5 (E15·5). Histological examination of embryos at E15·5 showed significantly fewer erythropoietic islands in the liver parenchyma, whereas their hearts showed no abnormal signs, such as cardiomegaly and apoptotic cells. The NS1-transgenic mouse lines established here provide an animal model for human NIHF and suggest that NS1 plays a crucial role in the adverse outcome associated with intrauterine B19 infection in humans.


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