scholarly journals Increased expression and secretion of interleukin-6 in human parvovirus B19 non-structural protein (NS1) transfected COS-7 epithelial cells

2006 ◽  
Vol 144 (1) ◽  
pp. 152-157 ◽  
Author(s):  
T.-C. Hsu ◽  
B.-S. Tzang ◽  
C.-N. Huang ◽  
Y.-J. Lee ◽  
G.-Y. Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Interleukin 6 ◽  
Parvovirus B19 ◽  
Human Parvovirus B19 ◽  
Structural Protein

A cytotoxic nonstructural protein, NS1, of human parvovirus B19 induces activation of interleukin-6 gene expression.

1996 ◽  
Vol 70 (12) ◽  
pp. 8485-8491 ◽  
Author(s):  
S Moffatt ◽  
N Tanaka ◽  
K Tada ◽  
M Nose ◽  
M Nakamura ◽  
...  
Keyword(s):  
Gene Expression ◽  
Interleukin 6 ◽  
Nonstructural Protein ◽  
Parvovirus B19 ◽  
Human Parvovirus B19

scholarly journals The human parvovirus B19 non-structural protein 1 N-terminal domain specifically binds to the origin of replication in the viral DNA

Virology ◽  
2014 ◽  
Vol 449 ◽  
pp. 297-303 ◽  
Author(s):  
Sunil Kumar Tewary ◽  
Haiyan Zhao ◽  
Xuefeng Deng ◽  
Jianming Qiu ◽  
Liang Tang
Keyword(s):  
Parvovirus B19 ◽  
Human Parvovirus B19 ◽  
Origin Of Replication ◽  
Structural Protein ◽  
Viral Dna ◽  
Terminal Domain

scholarly journals Establishment of a cell line expressing human parvovirus B19 non-structural protein from an inducible promoter.

1997 ◽  
Vol 78 (1) ◽  
pp. 215-219 ◽  
Author(s):  
M Leruez-Ville ◽  
U Hazan ◽  
I Vassias ◽  
C Pallier ◽  
F Morinet ◽  
...  
Keyword(s):  
Cell Line ◽  
Parvovirus B19 ◽  
Inducible Promoter ◽  
Human Parvovirus B19 ◽  
Structural Protein ◽  
A Cell

scholarly journals A transgenic mouse model for non-immune hydrops fetalis induced by the NS1 gene of human parvovirus B19

2002 ◽  
Vol 83 (2) ◽  
pp. 273-281 ◽  
Author(s):  
Hiroshi Chisaka ◽  
Eiji Morita ◽  
Kazuko Murata ◽  
Naoto Ishii ◽  
Nobuo Yaegashi ◽  
...  
Keyword(s):  
Transgenic Mice ◽  
Transgenic Mouse ◽  
Parvovirus B19 ◽  
Liver Parenchyma ◽  
Severe Anaemia ◽  
Hydrops Fetalis ◽  
Human Parvovirus B19 ◽  
Structural Protein

Human parvovirus B19 (B19) infection during pregnancy is associated with the adverse foetal outcome known as non-immune hydrops fetalis (NIHF). Although B19 is known to infect erythroid-lineage cells in vivo as well as in vitro, the mechanism leading to the occurrence of NIHF is not clear. To investigate the possible involvement of the B19 non-structural protein NS1 in NIHF, three independent lines of transgenic mice were generated that expressed NS1 under the control of the Cre-loxP system and the GATA1 promoter. Two of the three lines expressed NS1 in erythroid-lineage cells. Most of the transgenic mice died at the embryonic stage, some of which developed hydropic changes caused by severe anaemia at embryonic day 15·5 (E15·5). Histological examination of embryos at E15·5 showed significantly fewer erythropoietic islands in the liver parenchyma, whereas their hearts showed no abnormal signs, such as cardiomegaly and apoptotic cells. The NS1-transgenic mouse lines established here provide an animal model for human NIHF and suggest that NS1 plays a crucial role in the adverse outcome associated with intrauterine B19 infection in humans.

Sign in / Sign up

Export Citation Format

Share Document