Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency

The acute phase reaction is a systemic response to acute or chronic inflammation. The serum level of C-reactive protein (CRP) is the only acute phase biomarker widely used in routine clinical practice, including its uses for prognostics and therapy monitoring in cancer patients. Although Interleukin 6 (IL6) is a main trigger of the acute phase reactions, a series of acute phase reactants can contribute (e.g., other members in IL6 family or IL1 subfamily, and tumor necrosis factor α). However, the experience from patients receiving intensive chemotherapy for hematological malignancies has shown that, besides CRP, other biomarkers (e.g., cytokines, soluble cytokine receptors, soluble adhesion molecules) also have altered systemic levels as a part of the acute phase reaction in these immunocompromised patients. Furthermore, CRP and white blood cell counts can serve as a dual prognostic predictor in solid tumors and hematological malignancies. Recent studies also suggest that biomarker profiles as well as alternative inflammatory mediators should be further developed to optimize the predictive utility in cancer patients. Finally, the experience from allogeneic stem cell transplantation suggests that selected acute phase reactants together with specific markers of organ damages are useful for predicting or diagnosing graft versus host disease. Acute phase proteins may also be useful to identify patients (at risk of) developing severe immune-mediated toxicity after anticancer immunotherapy. To conclude, future studies of acute phase predictors in human malignancies should not only investigate the conventional inflammatory mediators (e.g., CRP, white blood cell counts) but also combinations of novel inflammatory parameters with specific markers of organ damages.

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C-reactive protein and complement as acute phase reactants in common carp Cyprinus carpio during CyHV-3 infection

Diseases of Aquatic Organisms ◽

10.3354/dao02727 ◽

2014 ◽

Vol 109 (3) ◽

pp. 187-199 ◽

Cited By ~ 19

Author(s):

N Pionnier ◽

M Adamek ◽

JJ Miest ◽

SJ Harris ◽

M Matras ◽

...

Keyword(s):

Common Carp ◽

Acute Phase ◽

Cyprinus Carpio ◽

C Reactive Protein ◽

Acute Phase Reactants ◽

Reactive Protein ◽

Common Carp Cyprinus Carpio ◽

Carp Cyprinus Carpio

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A study on correlations between C-reactive protein and certain other acute-phase reactants

Clinica Chimica Acta ◽

10.1016/0009-8981(61)90081-x ◽

1961 ◽

Vol 6 (2) ◽

pp. 170-173 ◽

Cited By ~ 10

Author(s):

Eugene W. Rice

Keyword(s):

Acute Phase ◽

C Reactive Protein ◽

Acute Phase Reactants ◽

Reactive Protein

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Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis

Tuberculosis Research and Treatment ◽

10.1155/2011/346295 ◽

2011 ◽

Vol 2011 ◽

pp. 1-7 ◽

Cited By ~ 1

Author(s):

Alejandro Sanchez ◽

Colleen Azen ◽

Brenda Jones ◽

Stan Louie ◽

Fred Sattler

Keyword(s):

Acute Phase ◽

Muscle Wasting ◽

Cell Mass ◽

Fat Free Mass ◽

C Reactive Protein ◽

Acute Phase Reactants ◽

Reactive Protein ◽

Low Levels ◽

Beta 2 Microglobulin ◽

Relationship Of

Background. Tuberculosis causes inflammation and muscle wasting. We investigated how attenuation of inflammation relates to repletion of body composition during treatment in an underserved population.Design. Twenty-four patients (23 to 79 years old) with pulmonary tuberculosis and inflammation (pretreatment albumin g/dL, C-reactive protein [CRP] μg/dL, and beta-2-microglobulin μg/L) were evaluated and had BIA over 24 weeks.Results. Weight increased by kg (5.5%; ) at week 4 and by kg (15.6%; ) at week 24. Repletion of body mass was primarily fat, which increased by kg at week 4 and kg at week 24 ( and versus baseline). Fat-free mass (FFM), body cell mass (BCM), and phase angle did not increase until study week 8. Albumin rose to g/dL by week 4 () and slowly increased thereafter. CRP levels declined by~50% at each interval visit.Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation.

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PROCALCITONIN, C-REACTIVE PROTEIN AND FIBRINOGEN LEVELS IN CASES WITH MECHANIC BOWEL OBSTRUCTION AND THEIR CHANGE IN RELATION TO THE DURATION OF OBSTRUCTION: AN EXPERIMENTAL STUDY

International Surgery ◽

10.9738/intsurg-d-15-00122.1 ◽

2017 ◽

Author(s):

Hakan Guzel ◽

Sahin Kahramanca ◽

Oskay Kaya ◽

Gulay Ozgehan ◽

Demet Yilmazer ◽

...

Keyword(s):

Acute Phase ◽

Bowel Obstruction ◽

Surgical Intervention ◽

Late Phase ◽

Study Groups ◽

Control Group ◽

C Reactive Protein ◽

Acute Phase Reactants ◽

Reactive Protein ◽

Mechanical Bowel Obstruction

The need and timing of surgical intervention in patients with adhesive bowel obstruction is a dilemma. We aimed to investigate the role of three acute-phase reactants, namely procalcitonin (PCT), fibrinogen and C-reactive protein (CRP) in this clinical condition We chose a rat model whose mechanical bowel obstruction was created with caecum ligation. There were two study groups and one control group. Each group contained ten subjects. The study groups had and six-hour obstruction samples. Blood PCT, fibrinogen and CRP levels were measured before and after the surgical procedure. These parameters were compared between the groups and they were also evaluated with the degree of histopathological changes occurred in terminal ileal tissue samples. Compared with the control group, PCT measurements showed a mild decrease in the early phase of obstruction but a significant elevation in the late phase (p: 0,977 and p: 0,001). Unlike PCT, fibrinogen levels increased at first but decreased later (p: 0,978 and p: 0,326). We observed an increase in CRP levels parallel to the prolonged duration of obstruction (p: 0,987 and p: 0,134). With regard to mucosal injury, PCT levels increased at first, and then decreased (p: 0,003). On the other hand, fibrinogen and CRP levels decreased at first, and then increased (p: 0,139 and p: 0,102). The acute-phase reactants PCT, fibrinogen and CRP associated with the duration of obstruction may help to determine the time of surgical intervention in patients with adhesive mechanical bowel obstruction.

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