scholarly journals PROCALCITONIN, C-REACTIVE PROTEIN AND FIBRINOGEN LEVELS IN CASES WITH MECHANIC BOWEL OBSTRUCTION AND THEIR CHANGE IN RELATION TO THE DURATION OF OBSTRUCTION: AN EXPERIMENTAL STUDY

2017 ◽  
Author(s):  
Hakan Guzel ◽  
Sahin Kahramanca ◽  
Oskay Kaya ◽  
Gulay Ozgehan ◽  
Demet Yilmazer ◽  
...  
Keyword(s):  
Acute Phase ◽  
Bowel Obstruction ◽  
Surgical Intervention ◽  
Late Phase ◽  
Study Groups ◽  
Control Group ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Mechanical Bowel Obstruction

The need and timing of surgical intervention in patients with adhesive bowel obstruction is a dilemma. We aimed to investigate the role of three acute-phase reactants, namely procalcitonin (PCT), fibrinogen and C-reactive protein (CRP) in this clinical condition We chose a rat model whose mechanical bowel obstruction was created with caecum ligation. There were two study groups and one control group. Each group contained ten subjects. The study groups had and six-hour obstruction samples. Blood PCT, fibrinogen and CRP levels were measured before and after the surgical procedure. These parameters were compared between the groups and they were also evaluated with the degree of histopathological changes occurred in terminal ileal tissue samples. Compared with the control group, PCT measurements showed a mild decrease in the early phase of obstruction but a significant elevation in the late phase (p: 0,977 and p: 0,001). Unlike PCT, fibrinogen levels increased at first but decreased later (p: 0,978 and p: 0,326). We observed an increase in CRP levels parallel to the prolonged duration of obstruction (p: 0,987 and p: 0,134). With regard to mucosal injury, PCT levels increased at first, and then decreased (p: 0,003). On the other hand, fibrinogen and CRP levels decreased at first, and then increased (p: 0,139 and p: 0,102). The acute-phase reactants PCT, fibrinogen and CRP associated with the duration of obstruction may help to determine the time of surgical intervention in patients with adhesive mechanical bowel obstruction.

scholarly journals Searching for methods to predict septic complications in surgical patients

2015 ◽  
Vol 96 (3) ◽  
pp. 294-297
Author(s):  
T Z Zakiev ◽  
S R Tuysin ◽  
A R Gil’fanov ◽  
R D Sagdiev ◽  
I V Zakieva
Keyword(s):  
Acute Phase ◽  
Albumin Level ◽  
Main Group ◽  
Water Soluble ◽  
Control Group ◽  
Study Group ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Cell Counts

Aim. To assess the significance of acute stage reactants as the marker for purulent complications in surgical patients.Methods. We analyzed the results of treatment of 228 patients with purulent and inflammatory diseases of soft tissues, treated in 2011-2014. Acute phase reactants: C-reactive protein, albumin and fibrinogen were measured starting from the day of admission and surgical treatment and during the next 7 days. The control group (112 patients) included patients whowere treated conventionally by gauze bandage with water-soluble ointments and antiseptic solutions and broad-spectrum antibiotics. In the study group (116 patients) topical treatment of wounds was performed using «Poliderm» bandages.Results. Application of the «Poliderm» combined dressing reduced the wounds clearance term from 4.3±0.5 to 3.2±0.4 days, active inflammation term from 8.8±1.3 to 6.4±0.7 days, epithelialization of the wound from 10.1±0.8 to 8.4±0.6 days. C-reactive protein level was 87.3±4.3 g/l at the day of admission and decreased by day 7 to 34.13±1.2 g/l, compared to 51.83±3.6 g/l on the 7th day in the control group. Albumin level was 42.73±3.7 g/l in the study group with further decrease to 40.33±1.7 g/l on the 2nd and subsequent increase up to 45.13±1.3 g/l on the day 7. Patients of the control group had albumin level decreased on the 2nd and 3rd days with further increase up to 41.73±2.1 g/l on the day 7. At the treatment start, leukocyte intoxication index was 5.923±0.4 in the main group and 5.873±0.3 in the control group. On the 2nd day, this parameter decreased to 5.12 in the main group and to 5.41 in the control group.Conclusion. Measuring the levels of acute phase reactants (C-reactive protein, albumin, etc.) allows to assess the clinical course of a purulent and inflammatory disease, to register the good treatment effect on the 1-2nd day of treatment, even before the significant clinical changes, changes in the body temperature, white blood cell counts, erythrocyte sedimentation rate.

scholarly journals The Variation of Pentraxin-3 in Febrile Patients Admitted With or Without Convulsions

2021 ◽  
Author(s):  
Şefika Bardak ◽  
Mine Cinbis ◽  
Yaşar Enli
Keyword(s):  
Blood Cell ◽  
Patient Group ◽  
Acute Phase ◽  
White Blood Cell ◽  
Pediatric Emergency ◽  
Control Group ◽  
Pentraxin 3 ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein

Objective: Febrile convulsions are the most frequent seizures in childhood. Pentraxin-3 is a new generation acute phase reactant that belongs to the family of long pentraxins. In our study, our primary aim was to investigate the difference in serum Pentraxin-3 levels between febrile convulsive patient group and non-convulsive fever control group. Our secondary aim was to evaluate the correlation between serum Pentraxin-3 levels and other more frequently used acute phase reactants (C-reactive protein, white blood cell count). Methods: Patients admitted to the pediatric emergency department between January 2014 and July 2014 were included in this prospective study The study included 35 febrile convulsive patients (patient group) and 35 non-convulsive febrile patients (control group) with similar age and gender, without chronic disease or ongoing medication brought to a university hospital Pediatric Emergency Department. Anamnesis information including active complaints, self and family history and laboratory findings of all cases included in the study were recorded on previously printed forms with demographic information such as age (month) and gender of the patient. In statistical analysis, the significance level was accepted as p <0,05. Results: There was no statistically significant difference between the groups in terms of age, gender, serum urea, creatinine, electrolytes, C-reactive protein and white blood cell counts (p>0,05). Serum Pentraxin-3 levels were 4,8±2,5 ng/ml in the patient group and 4.1±2.3 ng/ml in the control group. The difference between the two groups was not statistically significant (p>0,05). No correlation was found between Pentraxin-3 with C-reactive protein and white blood cell count. Conclusion: Our findings show that serum Pentraxine-3 levels are similar in patients with febrile convulsion and fever. In addition, it was concluded that Pentraxine-3 does not correlate with acute phase reactants, which are more commonly used.

scholarly journals Combined C-Reactive Protein and Novel Inflammatory Parameters as a Predictor in Cancer—What Can We Learn from the Hematological Experience?

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1966 ◽  
Author(s):  
Øystein Bruserud ◽  
Helene Hersvik Aarstad ◽  
Tor Henrik Anderson Tvedt
Keyword(s):  
Acute Phase ◽  
Hematological Malignancies ◽  
Phase Reaction ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Inflammatory Parameters ◽  
Cell Counts ◽  
Blood Cell Counts ◽  
White Blood Cell Counts

The acute phase reaction is a systemic response to acute or chronic inflammation. The serum level of C-reactive protein (CRP) is the only acute phase biomarker widely used in routine clinical practice, including its uses for prognostics and therapy monitoring in cancer patients. Although Interleukin 6 (IL6) is a main trigger of the acute phase reactions, a series of acute phase reactants can contribute (e.g., other members in IL6 family or IL1 subfamily, and tumor necrosis factor α). However, the experience from patients receiving intensive chemotherapy for hematological malignancies has shown that, besides CRP, other biomarkers (e.g., cytokines, soluble cytokine receptors, soluble adhesion molecules) also have altered systemic levels as a part of the acute phase reaction in these immunocompromised patients. Furthermore, CRP and white blood cell counts can serve as a dual prognostic predictor in solid tumors and hematological malignancies. Recent studies also suggest that biomarker profiles as well as alternative inflammatory mediators should be further developed to optimize the predictive utility in cancer patients. Finally, the experience from allogeneic stem cell transplantation suggests that selected acute phase reactants together with specific markers of organ damages are useful for predicting or diagnosing graft versus host disease. Acute phase proteins may also be useful to identify patients (at risk of) developing severe immune-mediated toxicity after anticancer immunotherapy. To conclude, future studies of acute phase predictors in human malignancies should not only investigate the conventional inflammatory mediators (e.g., CRP, white blood cell counts) but also combinations of novel inflammatory parameters with specific markers of organ damages.

scholarly journals Relationship of Acute Phase Reactants and Fat Accumulation during Treatment for Tuberculosis

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Alejandro Sanchez ◽  
Colleen Azen ◽  
Brenda Jones ◽  
Stan Louie ◽  
Fred Sattler
Keyword(s):  
Acute Phase ◽  
Muscle Wasting ◽  
Cell Mass ◽  
Fat Free Mass ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Low Levels ◽  
Beta 2 Microglobulin ◽  
Relationship Of

Background. Tuberculosis causes inflammation and muscle wasting. We investigated how attenuation of inflammation relates to repletion of body composition during treatment in an underserved population.Design. Twenty-four patients (23 to 79 years old) with pulmonary tuberculosis and inflammation (pretreatment albumin  g/dL, C-reactive protein [CRP]  μg/dL, and beta-2-microglobulin  μg/L) were evaluated and had BIA over 24 weeks.Results. Weight increased by  kg (5.5%; ) at week 4 and by  kg (15.6%; ) at week 24. Repletion of body mass was primarily fat, which increased by  kg at week 4 and  kg at week 24 ( and versus baseline). Fat-free mass (FFM), body cell mass (BCM), and phase angle did not increase until study week 8. Albumin rose to  g/dL by week 4 () and slowly increased thereafter. CRP levels declined by~50% at each interval visit.Conclusions. During the initial treatment, acute phase reactants returned towards normal. The predominant accrual of fat mass probably reflects ongoing, low levels of inflammation.

scholarly journals A study to observe quantitative levels of C- Reactive Protein in Cerebrospinal fluid in patients with Meningitis as an add-on routine investigation- a case-control study

2021 ◽  
Vol 9 (4) ◽  
pp. 235-240
Author(s):  
Manoj Kumar ◽  
◽  
Chandrashekhar Tiwari ◽  
Nandita Prabhat ◽  
Pooja Dhaon ◽  
...  
Keyword(s):  
Case Control Study ◽  
Case Control ◽  
Viral Meningitis ◽  
The Body ◽  
Control Group ◽  
P Value ◽  
C Reactive Protein ◽  
Acute Phase Reactants ◽  
Reactive Protein ◽  
Control Study

Introduction: C-reactive protein (CRP) is a member of the class of acute phase reactants as itslevel rises dramatically during inflammatory processes occurring in the body. Measuring and chartingCRP values can prove useful in determining the disease progress. Aim: To estimate the CRP level inCerebrospinal fluid (CSF) of patients with meningitis; and to evaluate whether CRP levels could beused to differentiate the various types of meningitis in adults. Materials and Methods: This studywas a case-control study. 80 enrolled patients were subjected to a protocol that included detailedclinical history including duration of illness, symptoms and signs, history or any treatment history.Written informed consent was taken from the patients/guardian. Results: Meningitis was morecommon in the 18-30 years age group. Mean values of CSF CRP were- viral meningitis (2.70 mg/L)and pyogenic meningitis (91.13 mg/L) and control group (1.54 mg/L). CSF CRP can be used as adiagnostic tool to differentiate between pyogenic and viral meningitis as it is significantly raised inpyogenic meningitis in comparison to viral meningitis (p-value <0.0001). Conclusion: CRP in CSF isa valuable, rapid, bedside diagnostic test for differentiating between pyogenic and viral meningitis;with reasonably good sensitivity, specificity and positive predictive value. The absence of CRP in CSFrather than its presence is more important for the diagnosis of viral meningitis.

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