Increased expression of SDF-1/CXCR4 is associated with lymph node metastasis of invasive micropapillary carcinoma of the breast

AbstractInvasive micropapillary carcinoma (IMPC) has very high rates of lymphovascular invasion and lymph node metastasis and has been reported in several organs. However, the genomic mechanisms underlying its metastasis are unclear. Here, we perform whole-genome sequencing of tumor cell clusters from primary IMPC and paired axillary lymph node metastases. Cell clusters in multiple lymph node foci arise from a single subclone of the primary tumor. We find evidence that the monoclonal metastatic ancestor in primary IMPC shares high frequency copy-number loss of PRDM16 and IGSF9 and the copy number gain of ALDH2. Immunohistochemistry analysis further shows that low expression of IGSF9 and PRDM16 and high expression of ALDH2 are associated with lymph node metastasis and poor survival of patients with IMPC. We expect these genomic and evolutionary profiles to contribute to the accurate diagnosis of IMPC.

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Loss of Leucine Zipper Putative Tumor Suppressor 1 (LZTS1) Expression Contributes to Lymph Node Metastasis of Breast Invasive Micropapillary Carcinoma

Pathology & Oncology Research ◽

10.1007/s12253-015-9923-x ◽

2015 ◽

Vol 21 (4) ◽

pp. 1021-1026 ◽

Cited By ~ 8

Author(s):

Xin-Xin Wang ◽

Bing-Bing Liu ◽

Xiao Wu ◽

Dan Su ◽

Zhengmao Zhu ◽

...

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Tumor Suppressor ◽

Leucine Zipper ◽

Invasive Micropapillary Carcinoma ◽

Micropapillary Carcinoma ◽

Node Metastasis ◽

Putative Tumor Suppressor

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The clinicopathological and prognostic characteristics of mucinous micropapillary carcinoma of the breast

10.21203/rs.3.rs-506309/v1 ◽

2021 ◽

Author(s):

yangyang sun ◽

wenxian gu ◽

gengfang wang ◽

xiaoli zhou

Keyword(s):

Lymph Node ◽

Lymph Node Metastasis ◽

Survival Time ◽

Vascular Invasion ◽

Clinical Characteristics ◽

Therapeutic Strategies ◽

Micropapillary Carcinoma ◽

Carcinoma Of The Breast ◽

Node Metastasis

Abstract Background Mucinous micropapillary carcinoma (MMPC) is a unique subtype of breast cancer and detailed investigation of clinical characteristics of MMPC is not fully investigated. Methods MMPC, pure mucinous breast carcinoma (PMBC) and invasive micropapollary carcinoma (IMPC) samples were enrolled simultaneously and performed immunohistochemistry (IHC) analysis to explore the clinicopathological attributes of MMPC. Moreover, survival analysis of MMPC were performed among MMPC, PMBC and IMPC group and within MMPC group. Results The result showed that MMPC demonstrated distinct pathological features and vascular invasion, lymph node metastasis were two significant clinical attributes of MMPC. MMPC encountered a decreased survival time than PMBC but an increased survival time than IMBC while TNM stage and lymph node metastasis were identified as two independent prognostic elements for DFS of MMPC prognosis. Conclusions The data implied that further understanding and classification of MMPC may provide better individualized therapeutic strategies for MMPC treatment.

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