Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases

2012 ◽  
Vol 62 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Stefano Sioletic ◽  
Paola Dal Cin ◽  
Christopher D M Fletcher ◽  
Jason L Hornick
Keyword(s):  
Myxoid Stroma ◽  
Well Differentiated

scholarly journals Atypical Lipomatous Tumor/Well-Differentiated Liposarcoma with Myxoid Stroma in a Hereditary Retinoblastoma Survivor

2019 ◽  
Vol 6 (2) ◽  
pp. 79-86
Author(s):  
Travis Peck ◽  
Kalla A. Gervasio ◽  
Paul J.L. Zhang ◽  
Carol L. Shields ◽  
Sara E. Lally ◽  
...  
Keyword(s):  
External Beam Radiotherapy ◽  
Molecular Genetic ◽  
Myxoid Liposarcoma ◽  
Atypical Lipomatous Tumor ◽  
Lipomatous Tumor ◽  
Myxoid Stroma ◽  
Molecular Genetic Data ◽  
Mesenchymal Neoplasm ◽  
Myxoid Liposarcomas ◽  
Well Differentiated

Atypical lipomatous tumor/well-differentiated liposarcoma (ALT/WDL) is an indolent, locally aggressive mesenchymal neoplasm, most often confined to the lower extremities and retroperitoneum and rarely identified in the orbit. Diagnosis of ALT/WDL can be challenging due to its frequent morphologic overlap with benign adipose lesions and other more aggressive liposarcoma subtypes, including myxoid liposarcoma. We describe a 26-year-old female with a history of hereditary retinoblastoma and external-beam radiotherapy to the orbit, who developed orbital liposarcoma. Although initial morphologic assessment raised the consideration of myxoid liposarcoma, subsequent fluorescein in situ hybridization studies demonstrated MDM2 and DDIT3 coamplification without DDIT3 rearrangement, supporting the diagnosis of ALT/WDL with myxoid stroma. The literature review of previously reported orbital myxoid liposarcomas revealed a morphologic overlap of documented tumors with ALT/WDL, dedifferentiated liposarcoma, and pleomorphic liposarcoma with myxoid stroma as well as an absence of immunohistochemical and molecular genetic data supportive of the diagnosis of myxoid liposarcoma. This case emphasizes the potential overlap of ALT/WDL with myxoid liposarcoma and the increasing importance of molecular genetic studies in the diagnosis, prognosis, and management of orbital liposarcoma.

scholarly journals Giant Spermatic Cord Liposarcoma

2014 ◽  
Vol 99 (4) ◽  
pp. 407-409
Author(s):  
Ugo Grossi ◽  
Antonio Crucitti ◽  
Francesco Pierconti
Keyword(s):  
Knee Joint ◽  
Spermatic Cord ◽  
Correct Diagnosis ◽  
Rare Tumor ◽  
Scrotal Mass ◽  
Myxoid Stroma ◽  
Inguinal Hernias ◽  
Well Differentiated ◽  
Myxoid Sarcoma

Abstract We report a case of giant spermatic cord liposarcoma (SCL) in an 81-year-old patient, presenting with a huge scrotal mass that reached up to the knee joint. SCL is a rare tumor, and about 200 cases have been reported in the literature so far. Although 20% of liposarcomas arise in the retroperitoneum, only 0.1% present as incidental inguinal hernias. The occasional presence of myxoid stroma in well-differentiated liposarcomas can lead to confusion with myxoid sarcoma subtypes. Correct diagnosis is critical and reflects remarkable differences in behavior and therapeutic choices.

Imaging appearance of well-differentiated liposarcomas with myxoid stroma

2018 ◽  
Vol 47 (10) ◽  
pp. 1371-1382
Author(s):  
Yoav Morag ◽  
Corrie Yablon ◽  
Monica Kalume Brigido ◽  
Jon Jacobson ◽  
David Lucas
Keyword(s):  
Imaging Appearance ◽  
Myxoid Stroma ◽  
Well Differentiated

scholarly journals An unusual origin of liposarcoma in an elderly man: a case report

2021 ◽  
Vol 8 (4) ◽  
pp. 1306
Author(s):  
Chin-Lun Tseng ◽  
Jui-Ho Wang
Keyword(s):  
Small Intestine ◽  
Tumor Resection ◽  
Gastrointestinal Symptoms ◽  
Exploratory Laparotomy ◽  
The Body ◽  
Fat Cells ◽  
Lower Abdomen ◽  
Palpable Mass ◽  
Myxoid Stroma ◽  
Well Differentiated

Liposarcoma is a type of cancer with mesenchymal origin in which the bulk of tumor differentiates into adipose tissue. Liposarcoma can be found in any part of the body with fat cells, but most cases occur in the muscles of the limbs or in the retroperitoneum. Here we report a case of an elderly man with an uncommon origin of liposarcoma. A 76-year-old man presented to hospital with gastrointestinal symptoms and a palpable mass over lower abdomen. Abdominal computer tomography revealed colonic tumor with another huge intraperitoneal mass, looks like originated from mesentery of small intestine. The patient underwent an exploratory laparotomy. During operation, despite colon cancer, a 17cm mass, originated from distal ileum mesentery was noted. The specimen histopathology of the tumor resection showed well-differentiated liposarcoma with prominent myxoid stroma. Finally, the patient was discharged on the tenth postoperative day. Most of liposarcomas origin from the extremities, retroperitoneum and inguinal region. However, we have chance to find liposarcomas everywhere in our body. In our case, it was a liposarcoma derived from mesentery of small intestine and it had few reports before.

scholarly journals Well-Differentiated Liposarcoma of the Hypopharynx Exhibiting Myxoid Liposarcoma-like Morphology with MDM2 and DDIT3 Co-Amplification

2021 ◽  
Author(s):  
Khaled A. Murshed ◽  
Hayan Abo Samra ◽  
Adham Ammar
Keyword(s):  
Spermatic Cord ◽  
Gene Rearrangement ◽  
Rare Event ◽  
Soft Tissue Sarcomas ◽  
Myxoid Liposarcoma ◽  
Posterior Wall ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Well Differentiated

AbstractWell-differentiated liposarcoma (WDL) is one of the most common soft tissue sarcomas in adults. It has a predilection for middle-aged males and arises in deep-seated locations such as retroperitoneum, mediastinum, and spermatic cord. Its occurrence in young individuals at the hypopharyngeal region is an exceedingly rare event. Myxoid liposarcoma (ML)-like changes can seldom occur in some cases of WDL, which makes the diagnosis of WDL more challenging. Amplification of DDIT3 gene in a subset of cases of WDL has shown to be associated with such unique morphology. Herein, we present a case of a 36-year-old gentleman who presented with difficulty in breathing and swallowing for 3 months duration. CT scan of the neck revealed a lesion along the posterior wall of the hypopharynx measuring 3.5 cm. Histopathologic examination revealed a tumor composed of lobules of oval to spindle cells in a prominent myxoid stroma with delicate chicken-wire vasculature. In the vicinity, there were lobules composed of variably sized adipocytes separated by thick fibrous septa that contains atypical hyperchromatic spindle cells. By immunohistochemistry, the tumor cells in both components were immunoreactive for CDK4, but negative for MDM2. Fluorescence in-situ hybridization (FISH) confirmed the presence of MDM2 gene amplification. There was no evidence of FUS-DDIT3 gene rearrangement, however, DDIT3 gene was also amplified. The diagnosis of well-differentiated liposarcoma with prominent myxoid stroma was rendered. This is the first documentation of WDL with ML-like morphology harboring co-amplification of MDM2 and DDIT3 in the hypopharynx.

Ultrastructure of NPC/HK1 cells heterotransplanted in athymic nude mice

1982 ◽  
Vol 40 ◽  
pp. 236-237
Author(s):  
E.C. Chew ◽  
C.L. Li ◽  
D.P. Huang ◽  
H.C. Ho ◽  
L.S. Mak ◽  
...  
Keyword(s):  
Cell Line ◽  
Nude Mice ◽  
Biopsy Specimen ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Recurrent Tumour ◽  
Athymic Nude Mice ◽  
Cell Line Establishment ◽  
Fine Structures ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been established from a biopsy specimen of a recurrent tumour of the nasopharynx which was histologically diagnosed as a moderately to well differentiated squamous cell carcinoma. A definite decrease in the amount of tonofilaments and desmosomes in the NPC/HK1 cells during the cell line establishment was observed. The present communication reports on the fine structures of the NPC/HK1 cells heterotraneplanted in athymic nude mice.

An Established Epithelial Cell Line (NPC/HK1) from a Nasopharyngeal Carcinoma - II. A Sem Study

1982 ◽  
Vol 40 ◽  
pp. 224-225
Author(s):  
Li C.L. ◽  
Chew E.C. ◽  
Huang D.P. ◽  
Ho H.C. ◽  
Mak L.S. ◽  
...  
Keyword(s):  
Nasopharyngeal Carcinoma ◽  
Epithelial Cell ◽  
Surface Morphology ◽  
Cell Line ◽  
Epithelial Cell Line ◽  
Present Communication ◽  
Cells In Culture ◽  
Sem Study ◽  
Well Differentiated

An epithelial cell line, NPC/HK1, has recently been successfully established from a nasopharyngeal carcinoma of the moderately to well differentiated squamous type. The present communication reports on the surface morphology of the NPC/HK1 cells in culture.

Motility of leukemic lymphocytes

1990 ◽  
Vol 48 (3) ◽  
pp. 368-369
Author(s):  
Manoj Raje ◽  
Karvita B. Ahluwalia
Keyword(s):  
Quantitative Data ◽  
Laser Doppler Velocimetry ◽  
Acute Lymphocytic Leukemia ◽  
Lymphocytic Leukemia ◽  
Cellular Space ◽  
Differentiated Cells ◽  
Poorly Differentiated ◽  
Solid Tissues ◽  
Well Differentiated ◽  
Reduced Mobility

In Acute Lymphocytic Leukemia motility of lymphocytes is associated with dissemination of malignancy and establishment of metastatic foci. Normal and leukemic lymphocytes in circulation reach solid tissues where due to in adequate perfusion some cells get trapped among tissue spaces. Although normal lymphocytes reenter into circulation leukemic lymphocytes are thought to remain entrapped owing to reduced mobility and form secondary metastasis. Cell surface, transmembrane interactions, cytoskeleton and level of cell differentiation are implicated in lymphocyte mobility. An attempt has been made to correlate ultrastructural information with quantitative data obtained by Laser Doppler Velocimetry (LDV). TEM of normal & leukemic lymphocytes revealed heterogeneity in cell populations ranging from well differentiated (Fig. 1) to poorly differentiated cells (Fig. 2). Unlike other cells, surface extensions in differentiated lymphocytes appear to originate by extrusion of large vesicles in to extra cellular space (Fig. 3). This results in persistent unevenness on lymphocyte surface which occurs due to a phenomenon different from that producing surface extensions in other cells.

Endoscopic submucosal dissection by using Clutch cutter and IT knife 2 for early gastric cancer with severe submucosal fibrosis: a case report

MedPharmRes ◽  
2018 ◽  
Vol 2 (3) ◽  
pp. 17-21
Author(s):  
Nhan Le ◽  
Phuong Vien ◽  
Nghia Le
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Endoscopic Submucosal Dissection ◽  
Narrow Band ◽  
Narrow Band Imaging ◽  
Magnifying Endoscopy ◽  
Gastrointestinal Cancers ◽  
Pathological Result ◽  
Well Differentiated ◽  
Submucosal Fibrosis

Introduction: Gastric cancer is one of the highly malignant gastrointestinal cancers and the third leading cause of cancer death. In the last decade, early gastric cancer (EGC) has been reported by using narrow-band imaging (NBI) magnifying endoscopy. Advances in endoscopic techniques, such as endoscopic submucosal dissection (ESD), have enabled the en bloc resection of these EGC. Although ESD is performed for early gastric cancer, there are still many difficult problems in technique of this procedure. The difficulty of gastric ESD depends on the size and location of a tumor, presence of severe submucosal fibrosis, presence of ulceration... We report a case of our successful ESD by using Clutch cutter and IT knife 2 in treatment of EGC with severe submucosal fibrosis. Case presentation: A 62-year-old man felt an epigastric discomfort two months ago. The narrow-band imaging (NBI) magnifying endoscopy revealed a suspected early gastric cancer type 0 - IIa + IIc (Japanese classification of early gastrointestinal cancers) at the incisura angularis, the size of this lesion was 15 mm in diameter, and pathological result of endoscopic biopsy was a well-differentiated adenocarcinoma. ESD was performed and we found there was severe submucosal fibrosis which was dissected safer and faster by using Clutch cutter and IT knife 2. There were no complications such as severe bleeding and perforation. The size of resected specimen was 60 x 35 mm and the time of procedure was 150 minutes. After ESD, the pathological result was a well differentiated adenocarcinoma, pT1a, UL(-), LY(-), V(-), no cancer cell in vertical and horizontal margins. The healing time of ESD-induced ulcer was 5 weeks without local recurrence. Conclusion: Through this case, we aim to emphasize the importance of using Clutch cutter and IT knife 2 as a modified technique which makes ESD a safe procedure in treatment of EGC with severe submucosal fibrosis.

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