scholarly journals Giant Spermatic Cord Liposarcoma

2014 ◽  
Vol 99 (4) ◽  
pp. 407-409
Author(s):  
Ugo Grossi ◽  
Antonio Crucitti ◽  
Francesco Pierconti
Keyword(s):  
Knee Joint ◽  
Spermatic Cord ◽  
Correct Diagnosis ◽  
Rare Tumor ◽  
Scrotal Mass ◽  
Myxoid Stroma ◽  
Inguinal Hernias ◽  
Well Differentiated ◽  
Myxoid Sarcoma

Abstract We report a case of giant spermatic cord liposarcoma (SCL) in an 81-year-old patient, presenting with a huge scrotal mass that reached up to the knee joint. SCL is a rare tumor, and about 200 cases have been reported in the literature so far. Although 20% of liposarcomas arise in the retroperitoneum, only 0.1% present as incidental inguinal hernias. The occasional presence of myxoid stroma in well-differentiated liposarcomas can lead to confusion with myxoid sarcoma subtypes. Correct diagnosis is critical and reflects remarkable differences in behavior and therapeutic choices.

scholarly journals Well-Differentiated Liposarcoma of the Hypopharynx Exhibiting Myxoid Liposarcoma-like Morphology with MDM2 and DDIT3 Co-Amplification

2021 ◽  
Author(s):  
Khaled A. Murshed ◽  
Hayan Abo Samra ◽  
Adham Ammar
Keyword(s):  
Spermatic Cord ◽  
Gene Rearrangement ◽  
Rare Event ◽  
Soft Tissue Sarcomas ◽  
Myxoid Liposarcoma ◽  
Posterior Wall ◽  
Myxoid Stroma ◽  
Spindle Cells ◽  
Well Differentiated

AbstractWell-differentiated liposarcoma (WDL) is one of the most common soft tissue sarcomas in adults. It has a predilection for middle-aged males and arises in deep-seated locations such as retroperitoneum, mediastinum, and spermatic cord. Its occurrence in young individuals at the hypopharyngeal region is an exceedingly rare event. Myxoid liposarcoma (ML)-like changes can seldom occur in some cases of WDL, which makes the diagnosis of WDL more challenging. Amplification of DDIT3 gene in a subset of cases of WDL has shown to be associated with such unique morphology. Herein, we present a case of a 36-year-old gentleman who presented with difficulty in breathing and swallowing for 3 months duration. CT scan of the neck revealed a lesion along the posterior wall of the hypopharynx measuring 3.5 cm. Histopathologic examination revealed a tumor composed of lobules of oval to spindle cells in a prominent myxoid stroma with delicate chicken-wire vasculature. In the vicinity, there were lobules composed of variably sized adipocytes separated by thick fibrous septa that contains atypical hyperchromatic spindle cells. By immunohistochemistry, the tumor cells in both components were immunoreactive for CDK4, but negative for MDM2. Fluorescence in-situ hybridization (FISH) confirmed the presence of MDM2 gene amplification. There was no evidence of FUS-DDIT3 gene rearrangement, however, DDIT3 gene was also amplified. The diagnosis of well-differentiated liposarcoma with prominent myxoid stroma was rendered. This is the first documentation of WDL with ML-like morphology harboring co-amplification of MDM2 and DDIT3 in the hypopharynx.

scholarly journals Hypertrophic Lichen Planus versus Well-Differentiated Squamous Cell Carcinoma: A Histological Challenge 

2017 ◽  
Vol 1 (2) ◽  
pp. 91
Author(s):  
Samuel P Haslam ◽  
Lindy S Ross ◽  
Alison C Lowe ◽  
Brent C Kelly
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Multiplex Pcr ◽  
Lichen Planus ◽  
Squamous Cell ◽  
Correct Diagnosis ◽  
Pseudoepitheliomatous Hyperplasia ◽  
Lichen Simplex Chronicus ◽  
Well Differentiated

Differentiating hypertrophic lichen planus (LP) from well-differentiated squamous cell carcinoma (SCC) is a histological challenge given the numerous histopathologic similarities between SCC and pseudoepitheliomatous hyperplasia (PEH) arising in the setting of hypertrophic LP. Multiple reports have shown that SCC can arise from hypertrophic LP not infrequently, but that the LP-to-SCC sequence is poorly understood, and many cases defy diagnosis due to histologic similarities. However, there are several clinical clues and histopathologic details that have shown to have some value when trying to ascertain the correct diagnosis. To the contrary, immunohistochemical tests have shown little promise in differentiating hypertrophic LP from SCC. Although multiplex PCR has shown some potential in differentiating PEH from SCC, this has only been in the setting of patients diagnosed with prurigo and lichen simplex chronicus, but not necessarily in the case hypertrophic LP. 

scholarly journals Retroperitoneal Liposarcoma Presenting as Bilateral Inguinal Hernias

2021 ◽  
Author(s):  
DO Haley S. Lehman ◽  
DO Ryan N. Qasawa ◽  
John J. Lim
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Mass Effect ◽  
Potential Space ◽  
Retroperitoneal Liposarcoma ◽  
Median Size ◽  
Inguinal Hernias ◽  
Retroperitoneal Tumors ◽  
Well Differentiated

Abstract Liposarcoma is one of the most common soft tissue sarcomas and has multiple subtypes, including atypical, well-differentiated, and dedifferentiated liposarcoma1. These tumors most commonly occur in the extremities and the retroperitoneum2, and account for 20% of all retroperitoneal tumors3. Retroperitoneal liposarcoma is very rare overall, occurring in 2.5 per one million people4. Patients will present from symptoms of mass effect due to the uncontrolled growth in the large potential space of the retroperitoneum, with its median size being around 30 cm5. The mainstay of treatment for this type of tumor is resection to a negative margin6. This is a case report describing a retroperitoneal liposarcoma presenting with bilateral inguinal hernias containing intraperitoneal fat from mass effect.

Well-Differentiated Neuroendocrine (Carcinoid) Tumors of the Extrahepatic Biliary Ducts

2010 ◽  
Vol 134 (7) ◽  
pp. 1075-1079
Author(s):  
Yvonne Saldanha Noronha ◽  
Anwar Sultana Raza
Keyword(s):  
Correct Diagnosis ◽  
Disease Free Survival ◽  
Needle Aspiration ◽  
Carcinoid Tumors ◽  
Endoscopic Retrograde ◽  
Free Survival ◽  
Accurate Preoperative Diagnosis ◽  
Biliary Ducts ◽  
Well Differentiated ◽  
Disease Free

Abstract Primary, well-differentiated neuroendocrine (carcinoid) tumors of the extrahepatic biliary ducts are an uncommon cause of biliary obstruction. As compared to cholangiocarcinomas, which are more commonly seen at this location, these tumors tend to behave less aggressively, and only one-third metastasize. Tumor size (>2 cm) appears to be the best predictor of aggressive behavior. Surgery is the mainstay of treatment and complete resection offers prolonged disease-free survival. Accurate preoperative diagnosis is therefore important and can be made by examining brush cytology specimens obtained during endoscopic retrograde cholangiopancreatography and/or endoscopic ultrasound-guided fine-needle aspiration. It is important to keep this entity in mind, especially when examining cytologic or small biopsy specimens, so that appropriate immunohistochemical stains can be used to arrive at the correct diagnosis.

scholarly journals Imaging, Surgical, and Pathology Findings of a Myxoid Aortic Sarcoma: When Distal Embolization Uncovers a Bigger Problem

Aorta ◽  
2018 ◽  
Vol 06 (02) ◽  
pp. 065-067
Author(s):  
Domenico Calcaterra ◽  
Carlo Rosati ◽  
Leslie Renfro ◽  
Panayotis Vardas
Keyword(s):  
Adjuvant Therapy ◽  
Correct Diagnosis ◽  
Rare Condition ◽  
Metastatic Spread ◽  
Distal Embolization ◽  
Tissue Diagnosis ◽  
Primary Disease ◽  
Disease Site ◽  
Well Differentiated ◽  
Aortic Sarcoma

AbstractAortic sarcomas are a very rare condition typically characterized by a deceiving presentation. Making a correct diagnosis is based on the application of an algorithm which allows to identify the primary disease site and to obtain a tissue diagnosis. Surgical aortic resection with adjuvant therapy offers the best palliation, particularly in cases of well-differentiated tumors with no evidence of diffuse metastatic spread.

scholarly journals Liposarcoma of the Spermatic Cord: A Case Report

2011 ◽  
Vol 2011 ◽  
pp. 1-2 ◽  
Author(s):  
M. S. Papageorgiou ◽  
G. Dadakas ◽  
K. Donev
Keyword(s):  
Case Report ◽  
Spermatic Cord ◽  
Rare Case ◽  
Malignant Tumors ◽  
Testicular Tumor ◽  
Unusual Site ◽  
Scrotal Mass

Liposarcomas are malignant tumors derived embryologically from mesodermal tissues. An unusual site of presentation is the spermatic cord, presenting as an inguinal or scrotal mass. We report a rare case of a liposarcoma of the spermatic cord, mimicking a testicular tumor. The patient was operated, and an orchidectomy, including the tumor, was performed. To our knowledge, there are about 185 similar cases reported in the literature.

scholarly journals Peritoneal mesothelioma masquerading as an inguinal hernia

2011 ◽  
Vol 93 (6) ◽  
pp. e107-e108 ◽  
Author(s):  
S Chakravartty ◽  
JC Singh ◽  
H Jayamanne ◽  
V Shah ◽  
GL Williams ◽  
...  
Keyword(s):  
Inguinal Hernia ◽  
Peritoneal Mesothelioma ◽  
Malignant Peritoneal Mesothelioma ◽  
Inguinal Hernias ◽  
Rare Tumours ◽  
Well Differentiated

We report a case of an 80-year-old man who presented with a right inguinal hernia that appeared incarcerated. On exploration a sausage shaped mass was found in the sac, which was debulked and histologically shown to be a well differentiated malignant peritoneal mesothelioma. Rare tumours may present as inguinal hernias and palliative debulking may be effective when they present in inguinal hernia sacs.

scholarly journals Gastric Plexiform Fibromyxoma Arising in the Cardia in an Adolescent Male: A Rare Tumor with an Unusual Location

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Awrad Nasralla ◽  
Mufeed Alwabari ◽  
Osama Alsaif ◽  
Samir S. Amr
Keyword(s):  
Abdominal Pain ◽  
North America ◽  
Gastrointestinal Stromal Tumor ◽  
Histopathological Examination ◽  
Correct Diagnosis ◽  
Clinical Manifestations ◽  
Adolescent Male ◽  
Rare Tumor ◽  
Review Of The Literature ◽  
Unique Case

Plexiform fibromyxoma of the stomach, also known as plexiform angiomyxoid myofibroblastic tumor, is a rare benign gastric mesenchymal tumor, first described in 2007, which usually arises in the gastric antrum and affects adults. Few cases have been reported in children and adolescents. It can present with different clinical manifestations including abdominal pain, dyspepsia, hematemesis, and vomiting. Preoperatively, this tumor is usually diagnosed as gastrointestinal stromal tumor (GIST), and the correct diagnosis is made only after histopathological examination following surgical resection. Most cases were reported from East Asia (China, Japan, and Korea), North America, and Europe. We report herein a unique case of plexiform fibromyxoma, the first to be reported from the Middle East, arising in the cardia of the stomach in a 16-year-old adolescent male, with a brief review of the literature.

Well-differentiated and dedifferentiated liposarcomas with prominent myxoid stroma: analysis of 56 cases

2012 ◽  
Vol 62 (2) ◽  
pp. 287-293 ◽  
Author(s):  
Stefano Sioletic ◽  
Paola Dal Cin ◽  
Christopher D M Fletcher ◽  
Jason L Hornick
Keyword(s):  
Myxoid Stroma ◽  
Well Differentiated
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