scholarly journals Heat shock up-regulates expression of Toll-like receptor-2 and Toll-like receptor-4 in human monocytes via p38 kinase signal pathway

Immunology ◽  
2005 ◽  
Vol 114 (4) ◽  
pp. 522-530 ◽  
Author(s):  
Jun Zhou ◽  
Huazhang An ◽  
Hongmei Xu ◽  
Shuxun Liu ◽  
Xuetao Cao
Keyword(s):  
Heat Shock ◽  
Signal Pathway ◽  
Human Monocytes ◽  
Toll Like Receptor ◽  
P38 Kinase ◽  
Toll Like Receptor 4 ◽  
Toll Like Receptor 2

scholarly journals Relationship between toll-like receptor 2 Arg677Trp and Arg753Gln and toll-like receptor 4 Asp299Gly polymorphisms and cytomegalovirus infection

2014 ◽  
Vol 25 ◽  
pp. 11-15 ◽  
Author(s):  
Agnieszka Jabłońska ◽  
Edyta Paradowska ◽  
Mirosława Studzińska ◽  
Patrycja Suski ◽  
Dorota Nowakowska ◽  
...  
Keyword(s):  
Cytomegalovirus Infection ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Toll Like Receptor 2

scholarly journals Detrimental Role of Heat Shock Protein 60&70 and Toll-like Receptor 4 in Skeletal Muscle Ischaemia In Vitro

2013 ◽  
Vol 57 (5) ◽  
pp. 77S
Author(s):  
Ali Navi ◽  
Rebekah Yu ◽  
Xu Shi-Wen ◽  
Sidney Shaw ◽  
George Hamilton ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Heat Shock Protein 60 ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
Muscle Ischaemia

scholarly journals Francisella tularensis LPS induces the production of cytokines in human monocytes and signals via Toll-like receptor 4 with much lower potency than E. coli LPS

2006 ◽  
Vol 18 (5) ◽  
pp. 785-795 ◽  
Author(s):  
Ana I Dueñas ◽  
Mónica Aceves ◽  
Antonio Orduña ◽  
Ramón Díaz ◽  
Mariano Sánchez Crespo ◽  
...  
Keyword(s):  
Francisella Tularensis ◽  
Human Monocytes ◽  
Toll Like Receptor ◽  
Toll Like Receptor 4 ◽  
E Coli

scholarly journals The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway

2002 ◽  
Vol 277 (23) ◽  
pp. 20847-20853 ◽  
Author(s):  
Ramunas M. Vabulas ◽  
Sibylla Braedel ◽  
Norbert Hilf ◽  
Harpreet Singh-Jasuja ◽  
Sylvia Herter ◽  
...  
Keyword(s):  
Endoplasmic Reticulum ◽  
Dendritic Cells ◽  
Heat Shock ◽  
Heat Shock Protein ◽  
Toll Like Receptor ◽  
Heat Shock Protein Gp96 ◽  
Toll Like Receptor 2

scholarly journals Varicella-Zoster Virus Activates Inflammatory Cytokines in Human Monocytes and Macrophages via Toll-Like Receptor 2

2005 ◽  
Vol 79 (20) ◽  
pp. 12658-12666 ◽  
Author(s):  
Jennifer P. Wang ◽  
Evelyn A. Kurt-Jones ◽  
Ok S. Shin ◽  
Michael D. Manchak ◽  
Myron J. Levin ◽  
...  
Keyword(s):  
Varicella Zoster Virus ◽  
Cell Line ◽  
Human Monocyte ◽  
Human Cell Line ◽  
Mouse Cell ◽  
Human Monocytes ◽  
Toll Like Receptor ◽  
Herpes Simplex Viruses ◽  
Varicella Zoster ◽  
Toll Like Receptor 2

ABSTRACT The pattern recognition receptor Toll-like receptor 2 (TLR2) has been implicated in the response to several human viruses, including herpes simplex viruses (types 1 and 2) and cytomegalovirus. We demonstrated that varicella-zoster virus (VZV) activates inflammatory cytokine responses via TLR2. VZV specifically induced interleukin-6 (IL-6) in human monocytes via TLR2-dependent activation of NF-κB, and small interfering RNA designed to suppress TLR2 mRNA reduced the IL-6 response to VZV in human monocyte-derived macrophages. Unlike other herpesviruses, the cytokine response to VZV was species specific. VZV did not induce cytokines in murine embryonic fibroblasts or in a mouse cell line, although VZV did activate NF-κB in a human cell line expressing a murine TLR2 construct. Together, these results suggest that TLR2 may play a role in the inflammatory response to VZV infection.

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