The response of subcutaneous connective tissue to newly developed calcium phosphate-based root canal sealers

2011 ◽  
Vol 44 (4) ◽  
pp. 342-352 ◽  
Author(s):  
R. M. Khashaba ◽  
M. M. Moussa ◽  
N. B. Chutkan ◽  
J. L. Borke
Keyword(s):  
Calcium Phosphate ◽  
Connective Tissue ◽  
Root Canal ◽  
Subcutaneous Connective Tissue ◽  
Root Canal Sealers

scholarly journals Tissue toxicity of root canal sealers

2004 ◽  
Vol 51 (3) ◽  
pp. 136-141 ◽  
Author(s):  
Mirjana Vujaskovic ◽  
Dragoljub Bacetic
Keyword(s):  
Connective Tissue ◽  
Root Canal ◽  
Tissue Reaction ◽  
Tissue Response ◽  
Control Material ◽  
Tissue Sections ◽  
Subcutaneous Connective Tissue ◽  
Tissue Reactions ◽  
Root Canal Sealers ◽  
Observation Period

The aim of this study was to evaluate tissue response to root canal sealers Tubuliseal and Sealapex. The sealers were freshly mixed and injected in the dorsal subcutaneous connective tissue of 12 Wistar rats.The observation periods were 7 days, 21days and 60 days. Four operative areas were formed ( 2 for test sealers, Tubliseal or Sealapex and 2 for control material) on each animal. Tissue sections were taken from selected sites. Each section included skin, subcutaneous connective tissue and underlying muscle tissue.All blocks were processed with the use of standardized histological procedures.The tissue reactions were studied under light microscopy. Different grades of tissue reaction to the tested materials were recorded as mild, moderate or severe inflammation. After seven days both root canal sealers showed severe inflammatory reaction of connective tissue in experimental animals.Tubuliseal caused prolonged moderate and mild inflammation. Sealapex caused mild inflammation which diminished at the end of the observation period. The results of this study demonstrated that Sealapex was better tolerated by tissue than Tubliseal.

In vivo comparison of the biocompatibility of two root canal sealers implanted into the subcutaneous connective tissue of rats

1998 ◽  
Vol 24 (2) ◽  
pp. 82-85 ◽  
Author(s):  
Ioannis Kolokouris ◽  
Nikolaos Economides ◽  
Panagiotis Beltes ◽  
Ioannis Vlemmas
Keyword(s):  
Connective Tissue ◽  
Root Canal ◽  
Subcutaneous Connective Tissue ◽  
Root Canal Sealers

In vivo comparison of the biocompatibility of two root canal sealers implanted into the subcutaneous connective tissue of rats

2007 ◽  
Vol 103 (5) ◽  
pp. e88-e94 ◽  
Author(s):  
Edilson José Zafalon ◽  
Marco Aurélio Versiani ◽  
Cássio José Alves de Souza ◽  
Camila Christian Gomes Moura ◽  
Paula Dechichi
Keyword(s):  
Connective Tissue ◽  
Root Canal ◽  
Subcutaneous Connective Tissue ◽  
Root Canal Sealers

scholarly journals Cytocompatibility and cell proliferation evaluation of calcium phosphate-based root canal sealers

2020 ◽  
Vol 45 (1) ◽  
Author(s):  
Letícia Boldrin Mestieri ◽  
Ivana Maria Zaccara ◽  
Lucas Siqueira Pinheiro ◽  
Fernando Branco Barletta ◽  
Patrícia Maria Polli Kopper ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Calcium Phosphate ◽  
Root Canal ◽  
Root Canal Sealers

scholarly journals Biocompatibility of four root canal sealers: a histopathological evaluation in rat subcutaneous connective tissue

2011 ◽  
Vol 22 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Camila Maggi Maia Silveira ◽  
Shelon Cristina Souza Pinto ◽  
Rosário de Arruda Moura Zedebski ◽  
Fábio André Santos ◽  
Gibson Luiz Pilatti
Keyword(s):  
Connective Tissue ◽  
Inflammatory Reaction ◽  
Root Canal ◽  
Descriptive Analysis ◽  
Giant Cells ◽  
Tissue Samples ◽  
Inflammatory Reactions ◽  
Ah Plus ◽  
Severe Inflammatory Reaction ◽  
Root Canal Sealers

The aim of this study was to evaluate the subcutaneous biocompatibility of: Epiphany, AH Plus, Pulp Canal Sealer and Sealapex root canal sealers. Sixty rats were randomly assigned to 4 groups, according to the sealer. Polyethylene tubes containing the tested materials were inserted into the connective tissue. The implants were removed after 7, 15 and 30 days, and the tissue samples were processed, stained and examined by light microscopy. The descriptive analysis considered: thickness of the fibrous capsule, severity of the inflammatory reaction, and presence of giant cells. After 7 days, all sealers induced moderate to severe inflammatory reaction. After 15 days, Epiphany and AH Plus sealers showed a moderate inflammatory reaction, while Pulp Canal Sealer and Sealapex induced severe and mild inflammatory reactions, respectively. After 30 days, mild inflammatory reactions were observed for Epiphany, Sealapex and AH Plus. Sealapex induced the lowest inflammatory response at all evaluation periods, and only Pulp Canal Sealer did not show a decreased in the inflammatory reaction over time.

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