Sperm motility inhibitor from human seminal plasma: presence of a precursor molecule in seminal vesicle fluid and its molecular processing after ejaculation

1994 ◽  
Vol 17 (5) ◽  
pp. 232-240 ◽  
Author(s):  
MARTIN ROBERT ◽  
CLAUDE GAGNON
Keyword(s):  
Seminal Vesicle ◽  
Sperm Motility ◽  
Seminal Plasma ◽  
Human Seminal Plasma ◽  
Precursor Molecule ◽  
Vesicle Fluid

SEMINAL PLASMA, BUT NOT SEMINAL VESICLE FLUID, INDUCES APOPTOSIS IN STIMULATED PERIPHERAL BLOOD LEUKOCYTES

1999 ◽  
pp. 284
Author(s):  
Mari Yakamoto ◽  
Thomas Mullins ◽  
Randal Byrn ◽  
Robert Eyre ◽  
Paul Church ◽  
...  
Keyword(s):  
Seminal Vesicle ◽  
Seminal Plasma ◽  
Peripheral Blood ◽  
Peripheral Blood Leukocytes ◽  
Blood Leukocytes ◽  
Vesicle Fluid

scholarly journals Decreased piRNAs in Infertile Semen Are Related to Downregulation of Sperm MitoPLD Expression

2021 ◽  
Vol 12 ◽  
Author(s):  
Yeting Hong ◽  
Yanqian Wu ◽  
Jianbin Zhang ◽  
Chong Yu ◽  
Lu Shen ◽  
...  
Keyword(s):  
Male Infertility ◽  
Sperm Motility ◽  
Seminal Plasma ◽  
Molecular Mechanisms ◽  
Molecular Biomarkers ◽  
Loss Of Function ◽  
Human Seminal Plasma ◽  
High Concentrations ◽  
Tight Correlation ◽  
Infertile Patients

Currently, the molecular mechanisms underlining male infertility are still poorly understood. Our previous study has demonstrated that PIWI-interacting RNAs (piRNAs) are downregulated in seminal plasma of infertile patients and can serve as molecular biomarkers for male infertility. However, the source and mechanism for the dysregulation of piRNAs remain obscure. In this study, we found that exosomes are present in high concentrations in human seminal plasma and confirmed that piRNAs are predominantly present in the exosomal fraction of seminal plasma. Moreover, we showed that piRNAs were significantly decreased in exosomes of asthenozoospermia patients compared with normozoospermic men. By systematically screening piRNA profiles in sperms of normozoospermic men and asthenozoospermia patients, we found that piRNAs were parallelly reduced during infertility. At last, we investigated the expression of some proteins that are essential for piRNAs biogenesis in sperms and therefore identified a tight correlation between the levels of spermatozoa piRNA and MitoPLD protein, suggesting that the loss-of-function of MitoPLD could cause a severe defect of piRNA accumulation in sperms. In summary, this study identified a parallel reduction of piRNAs and MitoPLD protein in sperms of asthenozoospermia patients, which may provide pathophysiological clues about sperm motility.

scholarly journals Analysis of bull (Bos taurus) seminal vesicle fluid proteome in relation to seminal plasma proteome

2017 ◽  
Vol 100 (3) ◽  
pp. 2282-2298 ◽  
Author(s):  
B. Westfalewicz ◽  
M.A. Dietrich ◽  
A. Mostek ◽  
A. Partyka ◽  
W. Bielas ◽  
...  
Keyword(s):  
Seminal Vesicle ◽  
Seminal Plasma ◽  
Bos Taurus ◽  
Plasma Proteome ◽  
Vesicle Fluid

High fat diet alters male seminal plasma composition to impair female immune adaptation for pregnancy in mice

Endocrinology ◽  
2021 ◽  
Author(s):  
John E Schjenken ◽  
Lachlan M Moldenhauer ◽  
David J Sharkey ◽  
Hon Yeung Chan ◽  
Peck Y Chin ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Seminal Vesicle ◽  
Seminal Plasma ◽  
High Fat Diet ◽  
Treg Cells ◽  
Female Reproductive Tract ◽  
Transcriptional Analysis ◽  
High Fat ◽  
Vesicle Fluid

Abstract Paternal experiences and exposures prior to conception can influence fetal development and offspring phenotype. The composition of seminal plasma contributes to paternal programming effects, through modulating the female reproductive tract immune response after mating. To investigate whether paternal obesity affects seminal plasma immune-regulatory activity, C57Bl/6 male mice were fed an obesogenic high fat diet (HFD) or control diet (CD) for 14 weeks. While HFD consumption caused only minor changes to parameters of sperm quality, the volume of seminal vesicle fluid secretions was increased by 65%, and the concentrations and total content of immune-regulatory TGFB isoforms were decreased by 75-80% and 43-55% respectively. Mating with BALB/c females revealed differences in the strength and properties of the post-mating immune response elicited. Transcriptional analysis showed >300 inflammatory genes were similarly regulated in the uterine endometrium by mating independently of paternal diet, but 13 were dysregulated by HFD-fed compared to CD-fed males. Seminal vesicle fluid factors reduced in HFD-fed males, including TGFB1, IL10, and TNF, were amongst the predicted upstream regulators of differentially regulated genes. Additionally, the T cell response induced by mating with CD-fed males was blunted after mating with HFD-fed males, with 27% fewer CD4 + T cells, 26% fewer FOXP3 +CD4 + regulatory T cells (Treg) cells, and 19% fewer CTLA4 + Treg cells, particularly within the NRP1 + thymic Treg cell population. These findings demonstrate that an obesogenic high fat diet alters the composition of seminal vesicle fluid and impairs seminal plasma capacity to elicit a favorable pro-tolerogenic immune response in females at conception.

Effect of Boar Seminal Plasma and Seminal Vesicle Fluid on Porcine Lymphocytes

1985 ◽  
Vol 15 (1) ◽  
pp. 29-32 ◽  
Author(s):  
R. Stanêk ◽  
L. Veselský ◽  
J. Dostál ◽  
E. Sedláková
Keyword(s):  
Seminal Vesicle ◽  
Seminal Plasma ◽  
Vesicle Fluid

scholarly journals Impact of Seminal Plasma Trace Elements on Human Sperm Motility Parameters

2018 ◽  
Vol 56 (1) ◽  
pp. 15-20 ◽  
Author(s):  
Mohammad Mostakhdem Hashemi ◽  
Nasser Behnampour ◽  
Mojgan Nejabat ◽  
Afsaneh Tabandeh ◽  
Behrouz Ghazi-Moghaddam ◽  
...  
Keyword(s):  
Trace Elements ◽  
Sperm Motility ◽  
Seminal Plasma ◽  
Sperm Quality ◽  
Semen Analysis ◽  
Sperm Concentration ◽  
Negative Relationship ◽  
Human Sperm ◽  
Computer Assisted ◽  
Human Seminal Plasma

Abstract Introduction. Human seminal plasma contains a variety of macro and trace elements including magnesium (Mg), copper (Cu), zinc (Zn), and iron (Fe) that have essential roles in normal functioning of semen and its quality. The imbalance of these elements has been reported in several pathologic and male infertility disorders. Therefore, this study aimed to determine the levels of these elements in seminal plasma samples, their relationships with each other and their impact on sperm motility. Methods. Overall, 192 males (96 normospermic and 96 asthenospermic males) were enrolled in the study. Semen samples were collected by masturbation and computer-assisted/aided semen analysis of sperm motility was performed. The samples were centrifuged and seminal levels of Mg, Cu, Zn and Fe were measured using atomic absorption spectroscopy. Results. The levels of Zn did not differ between the two groups, while the levels of Mg, Cu, and Fe were significantly higher in normospermic males. Fe showed a positive correlation with Mg and Cu in asthenospermic group. However, a negative relationship was found between Mg and Fe levels and between Mg and sperm concentration in the normospermic group. Fe levels were higher in the normospermic group compared to the asthenospermic group. Nevertheless, increased Fe levels caused a decrease in most of sperm motility fractions. Conclusion: Elements play major roles in male fertility and directly affect sperm quality. According to the results of this study, the levels of Zn do not affect the sperm quality and motility, while Fe, Cu and Mg are decreased in males with sperm motility problems. Nevertheless, Fe levels can adversely affect sperm motility in normospermic men.

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