Factors associated with maintenance of wakefulness test mean sleep latency in patients with mild to moderate obstructive sleep apnoea and normal subjects

AbstractObjective:To investigate voice function following Han's uvulopalatopharyngoplasty.Patients and methods:Acoustic and articulatory function was examined by acoustic analysis and by formant frequency and bandwidth analysis, before and after Han's uvulopalatopharyngoplasty, in 56 patients with obstructive sleep apnoea hypopnoea syndrome.Results:These patients' normalised noise energy was higher than normal, and improved post-operatively. Their pre-operative F1, F2, and F3 formant frequencies and B1 and B2 formant bandwidths were significantly lower than those of normal controls; however, one month after surgery their F1 and F2 frequencies were markedly higher.Conclusion:The acoustic and articulatory characteristics of obstructive sleep apnoea hypopnoea syndrome patients differed from those of normal subjects. After Han's uvulopalatopharyngoplasty, obstructive factors in the oropharynx were relieved, allowing oropharyngeal cavity expansion and a gradual increase in formant frequency to within the normal range. Patients' vocal quality improved and their resonator and articulator functions were protected and enhanced.

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Factors associated with undiagnosed obstructive sleep apnoea among hypertensive patients: A multisite cross-sectional survey study in Taiwan

Journal of Clinical Nursing ◽

10.1111/jocn.14366 ◽

2018 ◽

Vol 27 (9-10) ◽

pp. 1901-1912

Author(s):

Hsiu-Chin Hsu ◽

Ning-Hung Chen ◽

Wan Jing Ho ◽

Mei-Hsiang Lin

Keyword(s):

Obstructive Sleep Apnoea ◽

Sleep Apnoea ◽

Survey Study ◽

Cross Sectional Survey ◽

Cross Sectional ◽

Hypertensive Patients ◽

Factors Associated ◽

Obstructive Sleep

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α-Methyldopa selectively reduces alae nasi activity

Clinical Science ◽

10.1042/cs0740547 ◽

1988 ◽

Vol 74 (5) ◽

pp. 547-551 ◽

Cited By ~ 4

Author(s):

K. C. Lahive ◽

J. W. Weiss ◽

S. E. Weinberger

Keyword(s):

Obstructive Sleep Apnoea ◽

Upper Airway ◽

Normal Subjects ◽

Sleep Apnoea ◽

Emg Activity ◽

Obstructive Sleep ◽

Ventilatory Parameters ◽

The Mean ◽

Preliminary Study ◽

The Individual

1. Sedatives such as the benzodiazepines and alcohol reduce upper airway muscle activity. We hypothesized that a sedating antihypertensive, α-methyldopa, might have similar effects. To investigate this hypothesis we studied the effect of α-methyldopa on alae nasi electromyographic (EMG) activity during hypercapnia. 2. We studied ten healthy subjects and three subjects with obstructive sleep apnoea during CO2-stimulated breathing. In a preliminary study four subjects demonstrated a fall in alae nasi EMG activity 4 h after the ingestion of 500 mg of α-methyldopa during CO2 rebreathing. 3. In six additional normal subjects and three subjects with obstructive sleep apnoea, we studied the alae nasi EMG activity during steady-state hypercapnia with PCO2 held constant 5 torr (0.7 kPa) above baseline. On 2 separate days we studied subjects before and 2 h after they had ingested 750 mg of α-methyldopa or placebo. 4. In the normal subjects the mean alae nasi EMG activity fell by 34% 2 h after ingestion of α-methyldopa (P < 0.05) without a change in other ventilatory parameters. 5. In the sleep apnoea group the individual mean alae nasi EMG activity fell 16–49%, with ventilation and tidal volume falling in one patient. 6. We conclude that α-methyldopa selectively reduces upper airway motor activity.

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A Fully Remote Diagnostic and Treatment Pathway in Patients with Obstructive Sleep Apnoea during the COVID-19 Pandemic: A Single Centre Experience

Journal of Clinical Medicine ◽

10.3390/jcm10194310 ◽

2021 ◽

Vol 10 (19) ◽

pp. 4310

Author(s):

Andras Bikov ◽

Safia Khalil ◽

Meg Gibbons ◽

Andrew Bentley ◽

David Jones ◽

...

Keyword(s):

Obstructive Sleep Apnoea ◽

Positive Airway Pressure ◽

Sleep Apnoea ◽

Published Data ◽

Treatment Pathway ◽

Factors Associated ◽

Obstructive Sleep ◽

Single Centre Experience ◽

Set Up ◽

Index Disease

The COVID-19 pandemic led to significant delays in the diagnostic and management pathway of patients with obstructive sleep apnoea (OSA). During the first wave of COVID-19, our department adopted a fully remote diagnostic (home cardiorespiratory polygraphy) and treatment (autoset continuous positive airway pressure, CPAP) approach. As a novel mode of service delivery, our aim was to evaluate our pathway and analyse factors associated with adherence to CPAP. We analysed the first 300 patients (51 ± 13 years, 48% men) who were set up on remote CPAP between 20 May 2020 and 11 September 2020. The associations between CPAP usage at 90 days and age, gender, body mass index, disease severity, Epworth Sleepiness Scale and comorbidities were investigated with linear and logistic regression analyses. A total of 124 patients (41.3%) were fully-adherent to CPAP therapy, defined as CPAP usage ≥ 4 h on ≥ 70% of the days. Only driving status was associated with adherence to CPAP. Patients who were adherent at 28 days were more likely to stay adherent at 90 days (3.77 odd ratio /3.10–4.45/ 95% confidence interval). We have shown that a fully remote diagnostic and treatment pathway for patients with OSA can be successfully delivered, and our preliminary outcomes of adherence to CPAP are comparable with published data.

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Prevalence of obstructive sleep apnoea in metabolic syndrome

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20172261 ◽

2017 ◽

Vol 4 (3) ◽

pp. 722

Author(s):

A. P. Dubey ◽

Ashok K. Rajput ◽

Virender Suhag ◽

Durgesh Sharma ◽

Ajay Kandpal ◽

...

Keyword(s):

Metabolic Syndrome ◽

Obstructive Sleep Apnoea ◽

Sleep Disordered Breathing ◽

Early Stage ◽

Tertiary Care ◽

Sleep Apnoea ◽

Factors Associated ◽

Pedal Oedema ◽

Obstructive Sleep ◽

Overnight Polysomnography

Background: The prevalence of both OSA and metabolic syndrome is increasing worldwide, in part linked to the epidemic of obesity. Beyond their epidemiologic relationship, growing evidence suggests that OSA may be causally related to metabolic syndrome. We are only beginning to understand the potential mechanisms underlying the OSA-metabolic syndrome interaction. Objectives were to study the clinical prevalence of obstructive sleep apnoea in metabolic syndrome; and to find risk factors associated with obstructive sleep apnoea (OSA).Methods: 50 patients attending various OPDs of a tertiary care research and referral hospital and found to have metabolic syndrome on the basis of NCEP criteria were selected. These patients were subjected to overnight polysomnography. Parameters such as apnea-hypopnoea index (AHI), respiratory efforts related arousals (RERA), minimum SpO2, pulse rate, blood pressure, and ECG were monitored throughout the study.Results: Central obesity was found in 34 patients, xanthelasmas in 12 patients and xanthomas in 08 patients. Pitting type of pedal oedema was noted in 14 patients. Epworth sleepiness score (ESS) was calculated in all the patients by interviewing them before the polysomnography. Most of the patients have ESS Score more than 11.03 out of 50 patients were found to have AHI<5.20 patients were found to have moderate AHI (AHI 15-30) whereas 22 were found to have severe AHI.Conclusions: Polysomnography provides a valuable tool to access non symptomatic sleep disordered breathing at an early stage in patients with metabolic syndrome.

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